Product image of Isoprenaline Hydrochloride Macure Pharma Uk (Isoprenaline Hydrochloride) supplied by GNH India

Isoprenaline Hydrochloride Macure Pharma Uk

Active Ingredient:
Isoprenaline Hydrochloride
Origin:
EU

Isoprenaline Hydrochloride Macure Pharma Uk (Isoprenaline Hydrochloride)

Isoprenaline Hydrochloride, the active ingredient in Isoprenaline Hydrochloride Macure Pharma Uk, is a beta-adrenergic agonist presented as an injectable solution for intravenous use. It is employed to increase heart rate and contractility in bradyarrhythmia and to produce bronchodilation in asthma and bronchospasm patients.

GNH India supplies Isoprenaline Hydrochloride Macure Pharma Uk as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Macure Pharma Uk Limited

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Indications & Clinical Uses

Isoprenaline Hydrochloride acts on the sympathetic nervous system to modify cardiac and airway function.

  • Bradyarrhythmia: raises heart rate and improves cardiac output.
  • Asthma: relaxes bronchial smooth muscle to ease breathing.
  • Bronchospasm: provides rapid bronchodilation during acute airway constriction.

How It Works

  • Isoprenaline Hydrochloride non‑selectively stimulates beta‑1 and beta‑2 adrenergic receptors. Activation of beta‑1 receptors in the heart increases cyclic AMP, enhancing myocardial contractility and chronotropy. Stimulation of beta‑2 receptors in bronchial smooth muscle leads to cyclic AMP‑mediated relaxation, producing bronchodilation. The combined effect results in increased cardiac output and airway patency.

Side Effects

Isoprenaline Hydrochloride may cause a range of adverse reactions.

Common Side Effects

  • Tachycardia: rapid increase in heart rate.
  • Palpitations: awareness of heart beating.
  • Tremor: fine muscle shaking, especially in the hands.
  • Headache: mild to moderate pain.
  • Nausea: feeling of stomach upset.
  • Flushing: transient redness of the skin.

Serious or Rare Side Effects

  • Life‑threatening arrhythmias: abnormal heart rhythms.
  • Myocardial ischemia: reduced blood flow to heart muscle.
  • Severe hypotension: dangerous drop in blood pressure.
  • Pulmonary edema: fluid accumulation in lungs.
  • Anaphylactic reaction: severe allergic response.
  • Extreme bronchospasm: worsening airway constriction.

Precautions & Warnings

When using Isoprenaline Hydrochloride, clinicians should observe several safety measures.

  • Cardiac monitoring: continuous ECG is recommended during infusion.
  • Contraindication in severe tachyarrhythmia: avoid use in patients with existing fast heart rhythms.
  • Caution in hypertension: monitor blood pressure closely.
  • Diabetes monitoring: watch for altered glucose levels.
  • Interaction with beta‑blockers: may reduce therapeutic effect.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Isoprenaline Hydrochloride can interact with several drug classes.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers: antagonize bronchodilator and cardiac effects.
  • Class III antiarrhythmics (e.g., amiodarone): may cause additive cardiac stimulation.
  • Other sympathomimetics: increase risk of tachycardia and hypertension.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: may enhance hypotensive response.
  • Digoxin: increased risk of arrhythmias.
  • Tricyclic antidepressants: potential for heightened cardiovascular stimulation.
  • Diuretics: may exacerbate electrolyte disturbances.

Frequently Asked Questions

Isoprenaline Hydrochloride is prescribed to treat bradyarrhythmia, where it helps raise heart rate, and to manage asthma or bronchospasm by relaxing airway smooth muscle and improving breathing.

The drug non‑selectively activates beta‑1 receptors in the heart, increasing heart rate and contractility, and beta‑2 receptors in the lungs, causing smooth‑muscle relaxation and bronchodilation, thereby enhancing cardiac output and airway patency.

The appropriate dose of Isoprenaline Hydrochloride is determined by the prescribing clinician based on the patient’s condition, response, and clinical guidelines. Dosage regimens are individualized and should follow a qualified healthcare professional’s instructions.

Safety data for Isoprenaline Hydrochloride in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used if the potential benefits outweigh the risks, and under strict medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike selective beta‑2 agonists such as albuterol, Isoprenaline Hydrochloride stimulates both beta‑1 and beta‑2 receptors, offering combined cardiac stimulation and bronchodilation. This broader activity can be advantageous in certain emergency settings but may also increase the risk of cardiac side effects.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original packaging, protect it from moisture and direct light, and ensure the container is tightly sealed to maintain stability.

Isoprenaline Hydrochloride is administered intravenously by a qualified healthcare professional. The solution is typically infused over a controlled period, with dosage adjustments made according to the patient’s cardiac and respiratory response.

Serious risks include life‑threatening arrhythmias, myocardial ischemia, severe hypotension, pulmonary edema, and anaphylactic reactions. Prompt recognition and immediate medical intervention are essential if any of these events occur.

Patients with uncontrolled tachyarrhythmias, severe hypertension, recent myocardial infarction, or known hypersensitivity to the drug should not receive Isoprenaline Hydrochloride. Contraindications must be evaluated by a healthcare professional before therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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