Product image of Isoprenaline Hydrochloride Macure Pharma Uk (Isoprenaline Hydrochloride) supplied by GNH India

Isoprenaline Hydrochloride Macure Pharma Uk

Active Ingredient:
Isoprenaline Hydrochloride
Origin:
EU

Isoprenaline Hydrochloride Macure Pharma Uk (Isoprenaline Hydrochloride)

Isoprenaline Hydrochloride, the active ingredient in Isoprenaline Hydrochloride Macure Pharma Uk, is a beta‑adrenergic agonist presented as a sterile solution for intravenous use. It is employed to increase heart rate and contractility in bradycardia or heart block and to produce bronchodilation in asthma and bronchospasm patients.

GNH India supplies Isoprenaline Hydrochloride Macure Pharma Uk as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Macure Pharma Uk Limited

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Indications & Clinical Uses

Isoprenaline Hydrochloride acts on the sympathetic nervous system to manage conditions where increased cardiac output or airway relaxation is required.

  • Bradycardia: raises heart rate to restore adequate cardiac output.
  • Heart block: improves atrioventricular conduction to maintain rhythm.
  • Asthma: relaxes bronchial smooth muscle to ease breathing.
  • Bronchospasm: dilates airways during acute constriction episodes.

How It Works

  • Isoprenaline Hydrochloride is a non‑selective beta‑adrenergic receptor agonist that binds to β1 and β2 receptors. Activation of β1 receptors in cardiac tissue increases cyclic AMP, enhancing heart rate and myocardial contractility. Stimulation of β2 receptors in bronchial smooth muscle raises cyclic AMP, leading to relaxation and bronchodilation.

Side Effects

Isoprenaline Hydrochloride may cause a range of adverse reactions, some of which are dose‑related and reversible.

Common Side Effects

  • Tachycardia: rapid increase in heart rate.
  • Tremor: fine shaking of hands or limbs.
  • Headache: mild to moderate pain.
  • Nausea: feeling of stomach upset.

Serious or Rare Side Effects

  • Arrhythmias: potentially life‑threatening irregular heartbeats.
  • Myocardial ischemia: reduced blood flow to heart muscle.
  • Severe hypotension: dangerous drop in blood pressure.
  • Anaphylactic reaction: sudden severe allergic response.

Precautions & Warnings

Use of Isoprenaline Hydrochloride requires careful clinical monitoring and patient assessment.

  • Cardiac monitoring: continuously observe heart rhythm and rate.
  • Ischemic heart disease: assess risk before administration.
  • Hypertension: use cautiously in patients with high blood pressure.
  • Pheochromocytoma: avoid use in this condition.
  • Store at controlled room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Isoprenaline Hydrochloride can interact with several drug classes, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Beta‑blockers: antagonize therapeutic effects.
  • Calcium channel blockers: may precipitate severe hypotension.
  • MAO inhibitors: increase risk of hypertensive crisis.

Moderate Interactions (Monitor Closely)

  • Diuretics: monitor electrolyte balance and blood pressure.
  • Antihypertensives: adjust dosing to avoid excessive blood pressure reduction.

Frequently Asked Questions

Isoprenaline Hydrochloride is prescribed to treat bradycardia and heart block by increasing heart rate, as well as to relieve asthma and bronchospasm through bronchodilation. It is used in clinical settings where rapid cardiovascular stimulation or airway relaxation is needed.

The drug acts as a non‑selective beta‑adrenergic agonist, stimulating β1 receptors in the heart to raise heart rate and contractility, and β2 receptors in the lungs to relax bronchial smooth muscle, thereby improving airflow.

The dosage of Isoprenaline Hydrochloride is individualized and determined by the prescribing clinician based on the patient’s condition, response, and clinical guidelines. Specific dosing regimens are not provided here.

Safety data for Isoprenaline Hydrochloride in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike selective β2‑agonists such as albuterol, Isoprenaline Hydrochloride stimulates both β1 and β2 receptors, offering combined cardiac stimulation and bronchodilation. This broader activity can be advantageous in emergency settings but may increase the risk of cardiac side effects compared with more selective agents.

Store the product at controlled room temperature, typically below 25 °C. Keep it in the original packaging, protect it from moisture and direct light, and ensure the container is tightly sealed to maintain sterility.

Isoprenaline Hydrochloride is administered intravenously by a qualified healthcare professional. The infusion rate and concentration are adjusted according to the patient’s clinical response and monitoring parameters.

Serious risks include life‑threatening arrhythmias, myocardial ischemia, severe hypotension, and anaphylactic reactions. Immediate medical attention is required if any of these events occur during or after administration.

Patients with known hypersensitivity to the drug, uncontrolled hypertension, pheochromocytoma, or severe coronary artery disease should avoid Isoprenaline Hydrochloride. Contraindications must be evaluated by a healthcare professional before use.

Published by

GNH India Pharmaceuticals Limited

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