Product image of Isoprenaline Hydrochloride Synchrony Pharma (Isoprenaline Hydrochloride) supplied by GNH India

Isoprenaline Hydrochloride Synchrony Pharma

Active Ingredient:
Isoprenaline Hydrochloride
Origin:
EU

Isoprenaline Hydrochloride Synchrony Pharma (Isoprenaline Hydrochloride)

Isoprenaline Hydrochloride, the active ingredient in Isoprenaline Hydrochloride Synchrony Pharma, is a beta‑adrenergic agonist presented as an injectable solution for intravenous use. It is employed to increase heart rate and improve bronchodilation in patients with bradycardia, heart block, asthma or bronchospasm.
GNH India supplies Isoprenaline Hydrochloride Synchrony Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Synchrony Pharma Limited

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Indications & Clinical Uses

Isoprenaline Hydrochloride acts on the beta‑adrenergic system to treat several cardiac and respiratory conditions.

  • Bradycardia: raises heart rate to maintain adequate cardiac output.
  • Heart block: improves conduction through the atrioventricular node.
  • Asthma: relaxes bronchial smooth muscle to relieve airway obstruction.
  • Bronchospasm: provides rapid bronchodilation during acute episodes.

How It Works

  • Isoprenaline Hydrochloride is a non‑selective beta‑adrenergic receptor agonist that binds to β1 and β2 receptors, stimulating adenylate cyclase and increasing intracellular cyclic AMP. Elevated cAMP enhances calcium influx in cardiac myocytes, raising heart rate and contractility, while in bronchial smooth muscle it promotes relaxation, leading to bronchodilation.

Side Effects

Isoprenaline Hydrochloride may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Tachycardia: rapid increase in heart rate.
  • Palpitations: awareness of heart beating.
  • Headache: mild to moderate intensity.
  • Tremor: fine muscle shaking.
  • Nausea: occasional stomach upset.
  • Hypertension: elevated blood pressure.

Serious or Rare Side Effects

  • Life‑threatening arrhythmias.
  • Myocardial ischemia or infarction.
  • Severe hypotension.
  • Pulmonary edema.
  • Anaphylactic or severe allergic reactions.
  • Extreme bronchospasm despite therapy.

Precautions & Warnings

Careful clinical monitoring is required when using Isoprenaline Hydrochloride.

  • Cardiac monitoring: observe heart rate and rhythm continuously.
  • Coronary artery disease: use with caution due to increased myocardial oxygen demand.
  • Uncontrolled hypertension: avoid or adjust dose.
  • Renal impairment: consider dose reduction.
  • Pheochromocytoma: contraindicated because of catecholamine surge.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Isoprenaline Hydrochloride can interact with several drug classes, altering its efficacy or safety.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers: may blunt therapeutic effect.
  • MAO inhibitors: increase risk of hypertensive crisis.
  • Tricyclic antidepressants: potentiate cardiovascular stimulation.
  • Other sympathomimetics: may cause excessive tachycardia.
  • Ergot alkaloids: increase risk of severe vasospasm.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: may enhance negative inotropic effects.
  • Digoxin: risk of arrhythmias.
  • Diuretics: electrolyte shifts can affect cardiac response.
  • Anesthetic agents: may alter hemodynamic stability.
  • Antihypertensives: may require dose adjustments.

Frequently Asked Questions

Isoprenaline Hydrochloride Synchrony Pharma is prescribed to treat bradycardia, heart block, asthma and acute bronchospasm. By stimulating beta‑adrenergic receptors, it raises heart rate and relaxes airway smooth muscle, providing rapid clinical improvement in these cardiac and respiratory emergencies.

The drug acts as a non‑selective beta‑adrenergic agonist, binding to β1 receptors in the heart and β2 receptors in the lungs. Activation of these receptors increases cyclic AMP levels, which enhances cardiac contractility and rate while causing bronchodilation through smooth‑muscle relaxation.

The specific dose of Isoprenaline Hydrochloride is determined by the prescribing clinician based on the patient’s condition, weight, age, and response. Healthcare professionals adjust the intravenous infusion rate to achieve the desired therapeutic effect while monitoring vital signs.

Safety data for Isoprenaline Hydrochloride in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Compared with selective β1‑agonists such as dobutamine, Isoprenaline Hydrochloride stimulates both β1 and β2 receptors, producing a stronger increase in heart rate and more pronounced bronchodilation. This broader activity can be advantageous in combined cardiac‑respiratory emergencies but may also raise the risk of side effects like tachyarrhythmias.

Isoprenaline Hydrochloride should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight and extreme temperatures to maintain its stability and potency.

The medication is supplied as an injectable solution for intravenous infusion. Administration is performed by a qualified healthcare professional, who sets the infusion rate according to the patient’s clinical response and continuously monitors cardiac and respiratory parameters.

The most critical risks include life‑threatening arrhythmias, myocardial ischemia, severe hypertension or hypotension, pulmonary edema, and anaphylactic reactions. Prompt recognition and immediate medical intervention are essential if any of these serious adverse events occur.

Isoprenaline Hydrochloride is contraindicated in patients with pheochromocytoma, uncontrolled hypertension, severe coronary artery disease, or known hypersensitivity to the drug. It should also be used with extreme caution in individuals with recent myocardial infarction or significant electrolyte disturbances.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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