Isoprenaline Macure (Isoprenaline Hydrochloride)

Isoprenaline is a non‑selective beta‑adrenergic agonist. It binds to β1 receptors in the heart, increasing cyclic AMP and calcium influx, which accelerates heart rate and contractility. Simultaneously, activation of β2 receptors in bronchial smooth muscle raises cyclic AMP, causing muscle relaxation and bronchodilation. This dual action makes it valuable for both cardiac and respiratory emergencies.

The dose of Isoprenaline Macure is individualized by the prescribing clinician based on the patient’s condition, weight, and response. It is typically administered as an intravenous infusion that is titrated to achieve the desired heart‑rate or bronchodilatory effect, with careful monitoring of vital signs throughout the infusion.

Safety data for Isoprenaline in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Clinicians must evaluate each case carefully and discuss potential risks with the patient before initiating therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifying trade or institutional credentials before providing pricing, availability, shipping details (including cold‑chain if required), and necessary import documentation.

The primary alternatives are other beta‑agonists such as dobutamine or epinephrine. Compared with dobutamine, Isoprenaline has a stronger β2 effect, leading to more pronounced bronchodilation but also a higher risk of tachyarrhythmias. Epinephrine provides both alpha and beta stimulation, which can raise blood pressure, whereas Isoprenaline primarily increases heart rate and contractility without significant vasoconstriction.

Isoprenaline Macure should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from light, moisture, and extreme temperatures. Do not freeze the solution. Before use, inspect the vial for particulate matter or discoloration and follow aseptic techniques for preparation and administration.

Isoprenaline Macure is administered intravenously by a qualified healthcare professional. The solution is typically diluted in a compatible carrier fluid and infused via a controlled infusion pump. Dosage is titrated to achieve the desired clinical effect while continuously monitoring heart rhythm, blood pressure, and oxygen saturation.

The most critical risks include life‑threatening arrhythmias such as ventricular tachycardia, myocardial ischemia due to increased cardiac workload, severe hypotension, and pulmonary edema. Prompt recognition and immediate intervention are essential, and continuous cardiac monitoring is mandatory throughout therapy.

Isoprenaline is contraindicated in patients with uncontrolled ventricular tachyarrhythmias, severe coronary artery disease, recent myocardial infarction, or known hypersensitivity to the drug or its excipients. Caution is also advised in individuals with hyperthyroidism, severe hypertension, or those receiving other potent sympathomimetic agents.