Product image of Isoprinosine (Inosine Pranobex) supplied by GNH India

Isoprinosine

Active Ingredient:
Inosine Pranobex
Origin:
EU

Isoprinosine (Inosine Pranobex)

Inosine pranobex, the active ingredient in Isoprinosine, is an immunomodulator presented as an oral formulation for oral use. It is employed to support the immune response in viral infections such as herpes simplex, influenza, and human papillomavirus‑related warts, and in certain immunocompromised conditions.

GNH India supplies Isoprinosine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. We support regulatory compliance and post‑market surveillance for all customers.

Manufacturer / TM Owner

Ewopharma International S.R.O.

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Indications & Clinical Uses

Isoprinosine acts as an immunomodulatory antiviral, targeting viral replication and enhancing host defenses.

  • Herpes simplex infections: reduces lesion duration and severity.
  • Influenza and other acute viral respiratory infections: shortens illness course and alleviates symptoms.
  • Subacute sclerosing panencephalitis (SSPE): may slow disease progression.
  • Human papillomavirus (HPV) warts: promotes regression of cutaneous warts.
  • Immunostimulation in immunocompromised patients: supports immune function during infections.

How It Works

  • Inosine pranobex enhances cellular immunity by stimulating proliferation of T‑lymphocytes, increasing natural‑killer (NK) cell activity, and inducing interferon‑α/β production. The compound also modulates cytokine release, thereby strengthening antiviral defenses and facilitating clearance of infected cells. These mechanisms contribute to reduced viral load and improved clinical outcomes in treated patients.

Side Effects

Inosine pranobex may be associated with several adverse reactions, ranging from mild to severe.

Common Side Effects

  • Nausea: mild stomach upset that may be transient or persist during therapy.
  • Headache: mild to moderate pain often relieved with simple analgesics.
  • Dizziness: occasional light‑headedness, especially when standing quickly.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis): rapid onset of hives, swelling, breathing difficulty and possible shock.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis: serious skin rash with blistering and mucosal involvement.
  • Hepatic enzyme elevation or liver injury: abnormal liver function tests that may indicate liver stress.

Precautions & Warnings

Before prescribing Inosine pranobex, clinicians should consider several precautionary measures to ensure safe use.

  • Pregnancy: safety not established; use only if potential benefit justifies risk.
  • Breastfeeding: avoid unless benefits outweigh potential infant exposure.
  • Renal impairment: assess kidney function; dose adjustment may be required.
  • Hepatic disease: monitor liver enzymes regularly during treatment.
  • Concomitant immunosuppressants: evaluate risk of reduced efficacy or increased infection.
  • Store at ambient temperature below 25°C: keep in original packaging, protect from moisture and light.

Avoid Interactions

Inosine pranobex can interact with other medicines; awareness of major and moderate interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Immunosuppressive agents (e.g., cyclosporine, azathioprine): may diminish antiviral benefit.
  • Live vaccines: increased risk of vaccine‑derived infection.
  • Anticoagulants (e.g., warfarin): potential for enhanced bleeding tendency.

Moderate Interactions (Monitor Closely)

  • Antihistamines: may mask early signs of allergic reactions.
  • Corticosteroids: additive immunomodulatory effects may alter response.
  • Other antiviral agents: possible additive toxicity; monitor clinical status.

Frequently Asked Questions

Isoprinosine, containing the active ingredient Inosine pranobex, is prescribed to treat viral infections such as herpes simplex, influenza and other acute respiratory viruses, to manage human papillomavirus‑related warts, to slow progression of subacute sclerosing panencephalitis, and to provide immunostimulation in patients with compromised immune systems.

Inosine pranobex works by enhancing cellular immunity. It stimulates the proliferation of T‑lymphocytes, boosts natural‑killer (NK) cell activity, and induces the production of interferons. These actions increase the body’s antiviral defenses, helping to control and clear viral infections.

The appropriate dose of Isoprinosine is determined by the prescribing healthcare professional based on the specific indication, patient age, weight, renal and hepatic function, and other clinical factors. Patients should follow the dosage instructions provided by their prescriber and pharmacist.

Safety data for Inosine pranobex in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers should discuss individual risks and benefits with the patient.

To order Isoprinosine, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team then replies with pricing, availability, shipping details and any required import documentation.

The primary alternative for many viral infections is acyclovir or other nucleoside analogues, which act by directly inhibiting viral DNA polymerase. In contrast, Isoprinosine primarily modulates the host immune response rather than targeting the virus itself, offering a broader immunostimulatory effect that can be useful in conditions where direct antivirals are less effective.

Isoprinosine should be stored at ambient temperature below 25 °C, in its original packaging, protected from moisture and direct light. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments.

Isoprinosine is administered orally. The tablets (or other oral dosage form) should be swallowed whole with a glass of water, preferably with or after a meal to reduce gastrointestinal discomfort. Patients must follow the administration schedule prescribed by their healthcare provider.

Serious risks include severe allergic reactions such as anaphylaxis, skin conditions like Stevens‑Johnson syndrome or toxic epidermal necrolysis, and liver injury indicated by elevated hepatic enzymes. Patients should seek immediate medical attention if they experience rash, swelling, breathing difficulty, or signs of liver dysfunction such as jaundice.

Isoprinosine is contraindicated in individuals with known hypersensitivity to Inosine pranobex or any of its excipients. Patients with severe hepatic impairment, uncontrolled immune disorders, or those receiving live vaccines should avoid use unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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