Product image of Isoprinosine (Inosine Pranobex) supplied by GNH India

Isoprinosine

Active Ingredient:
Inosine Pranobex
Origin:
EU

Isoprinosine (Inosine Pranobex)

Inosine Pranobex, the active ingredient in Isoprinosine, is an immunomodulator presented as an oral tablet for oral use. It is employed to support the immune response in viral infections such as herpes simplex, influenza and human papillomavirus, and is used in both adult and pediatric patients under medical supervision.

GNH India supplies Isoprinosine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand.

Manufacturer / TM Owner

Ewopharma International S.R.O.

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Indications & Clinical Uses

Isoprinosine is used as an antiviral immunomodulator in several viral disease categories.

  • Herpes simplex infections: reduces lesion duration and viral shedding by enhancing host immunity.
  • Influenza: shortens illness course and alleviates symptoms through immune stimulation.
  • Subacute sclerosing panencephalitis (SSPE): may slow disease progression by supporting antiviral defenses.
  • Human papillomavirus infections: assists clearance of lesions by augmenting cellular immunity.
  • Other viral infections: provides broad‑spectrum support against diverse viral pathogens.

How It Works

  • Inosine Pranobex modulates the immune system by stimulating T‑lymphocyte proliferation and increasing interferon‑α production, which enhances antiviral activity. It also up‑regulates natural killer cell function and promotes cytokine release, leading to a broader immune response against viral pathogens. The compound also interferes with viral replication by affecting nucleic acid synthesis, and may modulate cytokine signaling pathways.

Side Effects

Isoprinosine may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Dizziness: occasional light‑headedness.
  • Rash: mild skin erythema or pruritus.

Serious or Rare Side Effects

  • Hematologic abnormalities: leukopenia or thrombocytopenia.
  • Hepatic dysfunction: elevated transaminases.
  • Severe allergic reactions: anaphylaxis or angioedema.

Precautions & Warnings

When prescribing Isoprinosine, consider the following precautions.

  • Pregnancy: safety not established; avoid unless benefit outweighs risk.
  • Renal impairment: dose adjustment may be required; monitor renal function.
  • Hepatic disease: use with caution; monitor liver enzymes.
  • Immunocompromised patients: assess risk‑benefit carefully.
  • Concomitant immunomodulators: may increase risk of adverse immune reactions.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and direct sunlight.

Avoid Interactions

Isoprinosine can interact with other medicines; review patient medication lists.

Major Interactions (Avoid)

  • Immunosuppressants: may counteract immunomodulatory effect.
  • Live vaccines: increased risk of altered vaccine response.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: potential for altered coagulation parameters.
  • Antihistamines: may enhance sedation.
  • CYP450 substrates: possible modest effect on metabolism.

Frequently Asked Questions

Isoprinosine, containing the active ingredient Inosine Pranobex, is employed as an immunomodulatory antiviral agent. It is indicated for the treatment of herpes simplex infections, influenza, subacute sclerosing panencephalitis, human papillomavirus infections, and other viral illnesses where enhancing the host immune response can aid viral clearance.

Inosine Pranobex acts by stimulating T‑cell proliferation and increasing interferon‑α production, which together boost the body’s antiviral defenses. It also enhances natural killer cell activity and promotes the release of cytokines, creating a broader immune response that can limit viral replication and spread.

The dosage of Isoprinosine is individualized by the prescribing clinician based on the specific indication, patient age, weight, and renal or hepatic function. Healthcare professionals determine the appropriate amount and schedule, and patients should follow the prescriber’s instructions without deviation.

Safety data for Isoprinosine during pregnancy and lactation are limited. It is generally classified as contraindicated or to be used only if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To order Isoprinosine, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Compared with nucleoside analogues such as acyclovir, Isoprinosine does not directly inhibit viral DNA polymerase. Instead, it modulates the immune system, offering a broader antiviral effect that may be useful in infections where conventional antivirals have limited activity. Clinical choice depends on the virus, disease severity, and patient-specific factors.

Isoprinosine tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original packaging to protect from moisture and direct sunlight. Do not store in damp areas or near heat sources, and keep out of reach of children.

Isoprinosine is administered orally, typically as a tablet that is swallowed with water. It is taken according to the schedule prescribed by the treating physician, which may involve multiple doses per day. Patients should not crush or chew the tablet unless specifically instructed.

Serious adverse events, although rare, include hematologic abnormalities such as leukopenia or thrombocytopenia, hepatic dysfunction indicated by elevated liver enzymes, and severe allergic reactions like anaphylaxis or angioedema. Patients should seek immediate medical attention if they experience unexplained bruising, jaundice, or signs of a severe allergic response.

Isoprinosine is contraindicated in individuals with known hypersensitivity to Inosine Pranobex or any excipients in the formulation. It should also be avoided in patients with severe immunodeficiency, uncontrolled hepatic or renal disease, and in pregnant or breastfeeding women unless the prescribing physician determines that the potential benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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