Product image of Isoptin Hta (Verapamil Hydrochloride) supplied by GNH India

Isoptin Hta

Active Ingredient:
Verapamil Hydrochloride
Origin:
EU

Isoptin Hta (Verapamil Hydrochloride)

Verapamil Hydrochloride, the active ingredient in Isoptin Hta, is a calcium channel blocker presented as an oral tablet for oral use. It is employed to manage high blood pressure, chest pain from angina, and certain rapid heart rhythms in adult patients.

GNH India supplies Isoptin Hta as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for cross‑border distribution. Customers benefit from reliable lead times and comprehensive support throughout the procurement process.

Manufacturer / TM Owner

Viatris Healthcare Lda.

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Indications & Clinical Uses

  • Isoptin Hta, a calcium channel blocker, is indicated for several cardiovascular conditions.
  • Hypertension: reduces systemic vascular resistance to lower blood pressure.
  • Angina pectoris: alleviates chest pain by decreasing myocardial oxygen demand.
  • Supraventricular tachyarrhythmias (e.g., atrial fibrillation, atrial flutter): slows atrioventricular nodal conduction to control heart rate.

How It Works

  • Verapamil Hydrochloride blocks L‑type calcium channels in cardiac myocytes and vascular smooth‑muscle cells, limiting calcium influx during depolarisation. This results in decreased myocardial contractility, prolonged atrioventricular nodal refractory period, and relaxation of arterial smooth muscle, producing antihypertensive, anti‑anginal, and anti‑arrhythmic effects. By reducing intracellular calcium, verapamil also diminishes the release of norepinephrine from sympathetic nerve endings, contributing to its blood‑pressure‑lowering action.

Side Effects

Verapamil Hydrochloride may be associated with a range of adverse reactions, which are categorised by frequency and severity.

Common Side Effects

  • Constipation: reduced gastrointestinal motility.
  • Dizziness or light‑headedness: due to blood‑pressure fall.
  • Headache: vascular dilation.
  • Peripheral oedema: fluid accumulation in lower limbs.

Serious or Rare Side Effects

  • Bradycardia: excessively slow heart rate.
  • Heart block: impaired electrical conduction.
  • Severe hypotension: sudden drop in blood pressure.
  • Hepatotoxicity: elevation of liver enzymes.

Precautions & Warnings

  • When prescribing Isoptin Hta, clinicians should consider several safety measures.
  • Cardiovascular assessment: evaluate heart rate and conduction before initiating therapy.
  • Concomitant beta‑blocker use: monitor for excessive bradycardia or AV block.
  • Liver impairment: adjust dose or monitor hepatic function.
  • Pregnancy and lactation: use only if benefits outweigh risks.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Verapamil Hydrochloride interacts with various medicines; some combinations require avoidance while others need close monitoring.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may cause toxic verapamil levels.
  • Digoxin: increased risk of digoxin toxicity.
  • Beta‑blockers: additive negative chronotropic effect.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce efficacy.
  • Antacids containing aluminium or magnesium: may decrease absorption.
  • Statins metabolised by CYP3A4 (e.g., simvastatin): increased risk of myopathy.

Frequently Asked Questions

Isoptin Hta contains verapamil hydrochloride and is prescribed to treat hypertension, angina pectoris, and supraventricular tachyarrhythmias such as atrial fibrillation or atrial flutter. It works by lowering blood pressure, reducing chest‑pain episodes, and controlling rapid heart rhythms.

Verapamil Hydrochloride blocks L‑type calcium channels in cardiac and vascular smooth‑muscle cells. This limits calcium entry, decreasing myocardial contractility, slowing atrioventricular nodal conduction, and causing arterial vasodilation, which together lower blood pressure, relieve angina, and stabilize abnormal heart rhythms.

The appropriate dose of Isoptin Hta is determined by the prescribing healthcare professional based on the individual’s condition, response, and tolerance. Dosage may be adjusted over time, and patients should follow the prescriber’s instructions without self‑adjusting the amount.

Safety data for verapamil in pregnancy and lactation are limited. The drug should be used only if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks with their healthcare provider.

To order Isoptin Hta, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Isoptin Hta (verapamil) primarily affects cardiac conduction and contractility, making it especially useful for arrhythmia control. Other blockers such as amlodipine have a stronger peripheral vasodilatory effect with less impact on heart rate, while diltiazem offers a balance between vascular and cardiac actions. Choice depends on the clinical indication and patient profile.

Store Isoptin Hta tablets at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Isoptin Hta is taken orally, usually as a tablet. It may be swallowed with or without food, according to the prescriber’s guidance. Patients should not crush or chew the tablet unless specifically instructed.

Serious adverse events include marked bradycardia, heart block, severe hypotension, and rare cases of liver toxicity. Patients should seek immediate medical attention if they experience fainting, very slow heart rate, sudden drop in blood pressure, or signs of liver injury such as jaundice.

Isoptin Hta is contraindicated in individuals with severe hypotension, second‑ or third‑degree atrioventricular block, sick‑sinus syndrome without a pacemaker, and in patients with known hypersensitivity to verapamil or any excipients in the tablet. Clinicians should also avoid use in patients with acute myocardial infarction unless specifically indicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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