Product image of Isoptin Mite (Verapamil Hydrochloride) supplied by GNH India

Isoptin Mite

Active Ingredient:
Verapamil Hydrochloride
Origin:
EU

Isoptin Mite (Verapamil Hydrochloride)

Verapamil hydrochloride, the active ingredient in Isoptin Mite, is a calcium channel blocker presented as an oral tablet for oral use. It reduces vascular resistance and myocardial contractility, making it useful for treating hypertension, alleviating angina pectoris, and stabilising certain cardiac arrhythmias in adult patients.

GNH India supplies Isoptin Mite as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality assurance and regulatory conformity across all markets. The company provides reliable logistics and documentation support for cross‑border procurement.

Manufacturer / TM Owner

Viatris Healthcare Gmbh

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Indications & Clinical Uses

Verapamil, a calcium channel blocker, is employed in several cardiovascular disorders where modulation of calcium influx improves vascular tone and cardiac electrical stability.

  • Hypertension: lowers systemic vascular resistance to help control high blood pressure.
  • Angina pectoris: reduces myocardial oxygen demand and improves coronary blood flow to relieve chest pain.
  • Cardiac arrhythmias: slows conduction through the AV node and stabilises abnormal heart rhythms such as supraventricular tachycardia.

How It Works

  • Verapamil blocks L‑type calcium channels in cardiac myocytes and vascular smooth muscle, decreasing intracellular calcium influx. This action reduces myocardial contractility and slows atrioventricular nodal conduction, while causing vasodilation of arterial smooth muscle, leading to lowered blood pressure and relief of ischemic chest pain.

Side Effects

Verapamil may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Constipation: reduced gastrointestinal motility.
  • Dizziness or light‑headedness: related to blood pressure lowering.
  • Headache: often transient during therapy initiation.
  • Flushing: due to peripheral vasodilation.
  • Peripheral edema: mild swelling of lower limbs.
  • Nausea: occasional gastrointestinal upset.

Serious or Rare Side Effects

  • Bradycardia: markedly slow heart rate requiring medical attention.
  • Severe hypotension: sudden drop in blood pressure that can cause fainting.
  • AV block or other conduction disturbances: may necessitate discontinuation.
  • Allergic reactions: rash, itching, or anaphylaxis in rare cases.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Monitor blood pressure: ensure adequate control without excessive hypotension.
  • Assess cardiac function: evaluate for existing conduction abnormalities.
  • Review concomitant medications: avoid additive effects with other rate‑controlling drugs.
  • Use caution in hepatic impairment: dose adjustments may be needed.
  • Avoid abrupt discontinuation: tapering reduces risk of rebound hypertension.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Verapamil can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Beta‑blockers: combined use may cause profound bradycardia or AV block.
  • Digoxin: verapamil can increase digoxin serum levels, raising toxicity risk.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may markedly raise verapamil concentrations.

Moderate Interactions (Monitor Closely)

  • Diuretics: concurrent use can enhance hypotensive effects and electrolyte shifts.
  • Statins metabolised by CYP3A4 (e.g., simvastatin): may increase statin exposure and risk of myopathy.

Frequently Asked Questions

Isoptin Mite, containing verapamil hydrochloride, is prescribed for managing hypertension, relieving angina pectoris, and controlling certain cardiac arrhythmias such as supraventricular tachycardia. It works by relaxing blood vessels and moderating heart rhythm, helping to lower blood pressure and reduce chest pain.

Verapamil hydrochloride blocks L‑type calcium channels in cardiac and vascular smooth muscle. By reducing calcium entry, it decreases myocardial contractility and slows conduction through the atrioventricular node, while also causing arterial vasodilation. These combined effects lower blood pressure, lessen heart workload, and help stabilize abnormal heart rhythms.

The appropriate dose of Isoptin Mite is determined by the prescribing healthcare professional based on the individual’s medical condition, response to therapy, and other factors. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety of verapamil during pregnancy or lactation has not been definitively established. Healthcare providers should weigh potential benefits against possible risks before prescribing Isoptin Mite to pregnant or nursing individuals. Women should discuss any concerns with their physician.

To request Isoptin Mite, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Isoptin Mite (verapamil) is a non‑dihydropyridine calcium channel blocker, distinguished by its pronounced effects on cardiac conduction and contractility. Compared with dihydropyridine agents such as amlodipine, verapamil has stronger negative inotropic and AV‑node slowing properties, making it preferable for certain arrhythmias but requiring careful monitoring of heart rate and blood pressure.

Isoptin Mite should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, excessive heat, and direct sunlight to maintain its stability and potency throughout its shelf life.

Isoptin Mite is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless specifically instructed by a healthcare professional. Dosing frequency and timing are set by the prescriber based on the therapeutic goal.

The most serious risks include severe bradycardia, marked hypotension, atrioventricular block, and rare allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience fainting, unusually slow heartbeats, chest discomfort, or signs of a severe allergic response.

Isoptin Mite is contraindicated in patients with known hypersensitivity to verapamil or any component of the formulation, those with severe sinus bradycardia, advanced heart block without a pacemaker, and in individuals with uncompensated heart failure. Clinicians must review a patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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