Product image of Isoptin Retard (Verapamil Hydrochloride) supplied by GNH India

Isoptin Retard

Active Ingredient:
Verapamil Hydrochloride
Origin:
EU

Isoptin Retard (Verapamil Hydrochloride)

Verapamil Hydrochloride, the active ingredient in Isoptin Retard, is a calcium channel blocker presented as an oral tablet for systemic use. It is employed to manage high blood pressure, chest pain from angina, and certain cardiac rhythm disturbances in adult patients.

GNH India supplies Isoptin Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Aps

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Indications & Clinical Uses

Isoptin Retard is a calcium channel blocker indicated for several cardiovascular conditions.

  • Hypertension: lowers elevated blood pressure by relaxing vascular smooth muscle.
  • Angina pectoris: reduces myocardial oxygen demand and improves coronary blood flow, relieving chest pain.
  • Cardiac arrhythmias: slows atrioventricular nodal conduction to control abnormal heart rhythms such as supraventricular tachycardia.

How It Works

  • Verapamil Hydrochloride blocks L‑type calcium channels on cardiac and vascular smooth‑muscle cells, decreasing intracellular calcium influx. This results in reduced myocardial contractility, slowed atrioventricular nodal conduction, and vasodilation of peripheral arteries, collectively lowering blood pressure and alleviating ischemic cardiac workload.

Side Effects

Adverse reactions may occur with verapamil therapy and should be monitored.

Common Side Effects

  • Dizziness: sensation of light‑headedness, especially after standing.
  • Headache: mild to moderate intensity.
  • Constipation: reduced bowel motility.
  • Peripheral edema: swelling of ankles or feet.

Serious or Rare Side Effects

  • Bradycardia: markedly slowed heart rate.
  • Hypotension: significant drop in blood pressure.
  • AV block: impaired atrioventricular conduction.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Blood pressure monitoring: ensure adequate control and avoid excessive hypotension.
  • Cardiac function assessment: evaluate for existing heart failure or conduction disorders.
  • Concomitant beta‑blocker use: assess risk of additive bradycardia.
  • Hepatic impairment: adjust therapy if severe liver disease is present.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Verapamil may interact with a range of medicines; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • Beta‑blockers: combined use can cause profound bradycardia or AV block.
  • Digoxin: increased serum levels may lead to toxicity.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): elevate verapamil concentrations.
  • Diltiazem: additive effects on cardiac conduction and contractility.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance hypotensive effect.
  • Simvastatin or other statins metabolized by CYP3A4: monitor for muscle toxicity.
  • Rifampin (CYP3A4 inducer): may reduce verapamil efficacy.
  • Lithium: monitor serum lithium levels for potential increase.

Frequently Asked Questions

Isoptin Retard contains verapamil hydrochloride and is prescribed to treat hypertension, angina pectoris, and certain cardiac arrhythmias. By lowering blood pressure, relieving chest pain, and controlling abnormal heart rhythms, it helps reduce cardiovascular risk in adult patients.

Verapamil Hydrochloride blocks L‑type calcium channels in cardiac and vascular smooth‑muscle cells. This inhibition reduces calcium entry, leading to decreased myocardial contractility, slowed atrioventricular nodal conduction, and vasodilation of peripheral arteries, which together lower blood pressure and lessen cardiac workload.

The specific dose of Isoptin Retard is determined by the prescribing clinician based on the patient’s condition, response, and tolerability. Dosage adjustments are made during treatment to achieve optimal therapeutic effect while minimizing adverse reactions.

Safety data for verapamil during pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Isoptin Retard belongs to the calcium‑channel‑blocker class, which primarily reduces vascular resistance through vasodilation. Compared with ACE inhibitors or ARBs, it has a more pronounced effect on heart rate and AV nodal conduction, making it useful for patients with concomitant angina or arrhythmias.

Store Isoptin Retard at ambient temperature, preferably below 25 °C, in the original container to protect it from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Isoptin Retard is taken orally, usually with a glass of water. It may be administered with or without food, but patients should follow the prescribing physician’s instructions regarding timing and any dietary considerations.

Serious risks include marked bradycardia, severe hypotension, atrioventricular block, and rare cases of heart failure or allergic reactions. Patients should seek immediate medical attention if they experience fainting, rapid weight gain, swelling, or signs of an allergic response.

Isoptin Retard is contraindicated in patients with known hypersensitivity to verapamil or any component of the formulation, those with severe hypotension, uncorrected second‑ or third‑degree AV block, and patients with acute myocardial infarction unless specifically directed by a cardiologist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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