Product image of Isoptin Retard (Verapamil Hydrochloride) supplied by GNH India

Isoptin Retard

Active Ingredient:
Verapamil Hydrochloride
Origin:
EU

Isoptin Retard (Verapamil Hydrochloride)

Verapamil Hydrochloride, the active ingredient in Isoptin Retard, is a calcium channel blocker presented as an oral tablet for oral use. It is employed to manage high blood pressure, chest pain from angina, and certain heart rhythm disorders in adult patients.
GNH India supplies Isoptin Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris As

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Indications & Clinical Uses

Isoptin Retard, a calcium channel blocker, is indicated for several cardiovascular conditions.

  • Hypertension: lowers elevated blood pressure by relaxing vascular smooth muscle.
  • Angina pectoris: reduces frequency and severity of chest pain by decreasing myocardial oxygen demand.
  • Supraventricular arrhythmias: helps restore normal heart rhythm by slowing conduction through the atrioventricular node.

How It Works

  • Verapamil Hydrochloride blocks L‑type calcium channels in cardiac and vascular smooth muscle, decreasing intracellular calcium influx. This results in reduced myocardial contractility, slowed atrioventricular nodal conduction, and vasodilation of arterial vessels, collectively lowering blood pressure and alleviating anginal and arrhythmic symptoms.

Side Effects

Isoptin Retard may cause a range of adverse reactions.

Common Side Effects

  • Constipation: mild to moderate difficulty passing stool.
  • Dizziness: sensation of light‑headedness, especially upon standing.
  • Headache: transient cranial discomfort.
  • Flushing: temporary reddening of the skin.
  • Peripheral edema: swelling of lower extremities.
  • Nausea: feeling of stomach upset.

Serious or Rare Side Effects

  • Bradycardia: abnormally slow heart rate.
  • Severe hypotension: marked drop in blood pressure.
  • Heart block: impaired electrical conduction in the heart.
  • Atrioventricular conduction disturbances: delayed signal transmission.
  • Allergic reactions: rash, itching, or anaphylaxis.
  • Hepatic dysfunction: abnormal liver enzyme elevations.

Precautions & Warnings

Before initiating therapy with Isoptin Retard, consider the following precautions.

  • Blood pressure monitoring: check baseline and periodic readings.
  • Cardiac function assessment: evaluate for existing conduction abnormalities.
  • Concomitant drug review: identify agents that may interact.
  • Hepatic impairment: adjust use in patients with liver disease.
  • Abrupt discontinuation: avoid sudden stop to prevent rebound hypertension.
  • Store at room temperature: keep in the original container, protect from moisture.

Avoid Interactions

Isoptin Retard can interact with several medications; awareness of these interactions helps ensure safety.

Major Interactions (Avoid)

  • Beta‑blockers: combined effect may cause excessive bradycardia.
  • Digoxin: increased serum levels can lead to toxicity.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may raise verapamil concentrations.

Moderate Interactions (Monitor Closely)

  • Diuretics: risk of electrolyte imbalance and hypotension.
  • Statins metabolized by CYP3A4 (e.g., simvastatin): higher risk of myopathy.
  • NSAIDs: may diminish antihypertensive efficacy.

Frequently Asked Questions

Isoptin Retard contains verapamil hydrochloride and is prescribed to treat hypertension, relieve angina pectoris, and manage certain supraventricular arrhythmias by modulating calcium influx in cardiac and vascular tissues.

Verapamil blocks L‑type calcium channels on cardiac myocytes and vascular smooth muscle, reducing intracellular calcium. This leads to decreased heart contractility, slowed AV‑node conduction, and vasodilation, which together lower blood pressure and alleviate chest pain and abnormal heart rhythms.

The specific dose of Isoptin Retard is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and other factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for verapamil in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Isoptin Retard, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Isoptin Retard (verapamil) primarily affects cardiac conduction and contractility, whereas agents like diltiazem have a more balanced vascular and cardiac effect. Choice between them depends on the clinical scenario, such as the need for stronger rate control (favoring verapamil) versus broader vasodilation.

Store Isoptin Retard at room temperature, below 25 °C, in the original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children.

Isoptin Retard is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow any specific instructions from their prescriber regarding timing relative to meals.

Serious risks include marked bradycardia, severe hypotension, heart block, atrioventricular conduction disturbances, allergic reactions such as anaphylaxis, and rare hepatic dysfunction. Patients should seek immediate medical attention if they experience fainting, severe dizziness, or signs of an allergic response.

Isoptin Retard is contraindicated in patients with known hypersensitivity to verapamil, severe hypotension, advanced heart block without a pacemaker, and in those with cardiogenic shock. Caution is also advised for individuals with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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