Product image of Isoptin Rr (Verapamil Hydrochloride) supplied by GNH India

Isoptin Rr

Active Ingredient:
Verapamil Hydrochloride
Origin:
EU

Isoptin Rr (Verapamil Hydrochloride)

Verapamil Hydrochloride, the active ingredient in Isoptin Rr, is a calcium channel blocker presented as an oral formulation for oral use. It is employed in the management of hypertension, angina pectoris, and certain cardiac arrhythmias such as atrial fibrillation.
GNH India supplies Isoptin Rr as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Healthcare Gmbh

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Indications & Clinical Uses

Isoptin Rr acts on the cardiovascular system to control blood pressure and heart rhythm.

  • Hypertension: lowers systemic arterial pressure by vasodilation.
  • Angina pectoris: reduces myocardial oxygen demand and improves coronary blood flow.
  • Atrial fibrillation: slows atrioventricular nodal conduction to help maintain regular rhythm.

How It Works

  • Verapamil Hydrochloride blocks L‑type calcium channels in cardiac myocytes and vascular smooth muscle, decreasing intracellular calcium influx. This results in vasodilation, reduced myocardial contractility, and slowed conduction through the atrioventricular node, contributing to its antihypertensive and antiarrhythmic effects.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Constipation: reduced gastrointestinal motility.
  • Dizziness: transient orthostatic changes.
  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness of skin.

Serious or Rare Side Effects

  • Bradycardia: markedly slowed heart rate.
  • Hypotension: significant drop in blood pressure.
  • AV block: impaired atrioventricular conduction requiring monitoring.

Precautions & Warnings

Careful assessment and monitoring are required when using Isoptin Rr.

  • Blood pressure monitoring: ensure adequate control and avoid excessive drops.
  • Cardiac function review: evaluate for existing heart block or heart failure.
  • Concomitant beta‑blocker use: increase risk of bradycardia and AV block.
  • Hepatic impairment: consider dose adjustment due to altered metabolism.
  • Abrupt discontinuation: taper to prevent rebound hypertension.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Verapamil may interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Beta‑blockers: additive bradycardia and AV block.
  • Digoxin: increased serum digoxin concentrations.
  • Diltiazem: enhanced risk of conduction disturbances.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., erythromycin): may raise verapamil levels.
  • Statins metabolized by CYP3A4 (e.g., simvastatin): increased risk of myopathy.

Frequently Asked Questions

Isoptin Rr contains verapamil hydrochloride and is prescribed to treat hypertension, angina pectoris, and atrial fibrillation. It works by relaxing blood vessels and slowing heart conduction, helping to control blood pressure and reduce chest pain or irregular heart rhythms.

Verapamil hydrochloride blocks L‑type calcium channels in cardiac and vascular smooth muscle. This inhibition reduces calcium entry into cells, leading to vasodilation, decreased myocardial contractility, and slowed atrioventricular nodal conduction, which together lower blood pressure and stabilize heart rhythm.

The specific dose of Isoptin Rr is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and other factors. Patients should follow the dosage instructions provided by their healthcare professional and not adjust the dose on their own.

Safety of verapamil during pregnancy or lactation has not been fully established. Healthcare providers will weigh potential benefits against possible risks before prescribing it to pregnant or nursing patients. Women should discuss their situation with a qualified medical professional.

To request Isoptin Rr, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Isoptin Rr (verapamil) is a non‑dihydropyridine calcium channel blocker, primarily affecting cardiac conduction and contractility, whereas dihydropyridine agents such as amlodipine mainly cause peripheral vasodilation. Verapamil is often chosen for its anti‑arrhythmic properties, while other agents may be preferred for isolated hypertension.

Store Isoptin Rr at room temperature, below 25 °C, in the original packaging. Keep the product away from moisture, direct sunlight, and excessive heat to maintain its stability and potency.

Isoptin Rr is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare professional.

Serious risks include marked bradycardia, severe hypotension, and atrioventricular block, which can lead to fainting or cardiac arrest. Patients should be monitored for these events, especially when initiating therapy or adjusting doses.

Isoptin Rr is contraindicated in patients with known hypersensitivity to verapamil, severe left ventricular dysfunction, advanced heart block without a pacemaker, and in those with uncontrolled heart failure. Clinicians must evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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