Product image of Isoptin Rr (Verapamil Hydrochloride) supplied by GNH India

Isoptin Rr

Active Ingredient:
Verapamil Hydrochloride
Origin:
EU

Isoptin Rr (Verapamil Hydrochloride)

Verapamil Hydrochloride, the active ingredient in Isoptin Rr, is a calcium channel blocker presented as an oral tablet for oral use. It is employed to manage high blood pressure, chest pain from angina, and certain rapid heart rhythms in adult patients.
GNH India supplies Isoptin Rr as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Healthcare Limited

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Isoptin Rr acts on the cardiovascular system by modulating calcium influx, which influences blood pressure and heart rhythm.

  • Hypertension: lowers systolic and diastolic pressure to reduce cardiovascular risk.
  • Angina pectoris: decreases myocardial oxygen demand and relieves chest pain.
  • Supraventricular tachyarrhythmias: slows conduction through the AV node to control rapid heart rates.

How It Works

  • Verapamil Hydrochloride blocks L‑type calcium channels in cardiac myocytes and vascular smooth muscle. This inhibition reduces intracellular calcium, leading to decreased myocardial contractility, slowed atrioventricular conduction, and relaxation of peripheral arteries, which together lower blood pressure and alleviate angina while controlling certain arrhythmias.

Side Effects

Common Side Effects

  • Constipation: mild to moderate difficulty passing stool.
  • Headache: transient pressure sensation.
  • Dizziness: feeling of light‑headedness, especially on standing.
  • Flushing: warm, reddened skin.
  • Peripheral edema: swelling of ankles or feet.
  • Nausea: upset stomach.

Serious or Rare Side Effects

  • Bradycardia: abnormally slow heart rate.
  • Severe hypotension: marked drop in blood pressure.
  • Heart block: impaired electrical conduction.
  • Allergic reaction: rash, itching, swelling, or breathing difficulty.
  • Hepatic enzyme elevation: abnormal liver function tests.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Blood pressure monitoring: ensure adequate control and avoid excessive drops.
  • Cardiac function assessment: evaluate for existing conduction disorders.
  • Concomitant beta‑blocker use: adjust doses to prevent excessive bradycardia.
  • Hepatic impairment: consider dose reduction in patients with liver dysfunction.
  • Abrupt discontinuation: taper gradually to avoid rebound hypertension.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Verapamil may interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Beta‑blockers: risk of profound bradycardia and hypotension.
  • Digoxin: increased serum levels leading to toxicity.
  • Diltiazem: additive cardiac conduction slowing.
  • Quinidine: heightened antiarrhythmic effect.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): elevated verapamil concentrations.

Moderate Interactions (Monitor Closely)

  • Amiodarone: possible increase in verapamil levels.
  • Statins (especially simvastatin): enhanced risk of myopathy.
  • Macrolide antibiotics: modest rise in plasma concentration.
  • Other antihypertensives: additive blood pressure lowering.
  • NSAIDs: may reduce antihypertensive efficacy.

Frequently Asked Questions

Isoptin Rr, containing verapamil hydrochloride, is prescribed for hypertension, angina pectoris, and supraventricular tachyarrhythmias. It helps lower blood pressure, relieve chest pain, and control rapid heart rhythms by acting on calcium channels in the heart and blood vessels.

Verapamil hydrochloride blocks L‑type calcium channels in cardiac and vascular smooth muscle. This reduces calcium entry into cells, leading to decreased heart muscle contraction, slower electrical conduction through the AV node, and relaxation of peripheral arteries, which together lower blood pressure and reduce cardiac workload.

The specific dose of Isoptin Rr is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and other factors. Patients should follow the dosage instructions provided by their healthcare professional and not adjust the dose on their own.

Safety of verapamil during pregnancy or lactation has not been definitively established. Healthcare providers will weigh potential benefits against possible risks before prescribing it to pregnant or nursing individuals. Patients should discuss any concerns with their physician.

To order Isoptin Rr, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Isoptin Rr (verapamil) is a non‑dihydropyridine calcium channel blocker, primarily affecting cardiac conduction and contractility, whereas dihydropyridine agents like amlodipine mainly cause vascular smooth‑muscle relaxation. Verapamil is often chosen for its antiarrhythmic properties, while others are preferred for pure antihypertensive effects.

Isoptin Rr should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and excessive heat to maintain its stability and potency.

Isoptin Rr is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless directed by a healthcare professional. Dosing times (e.g., with or without food) are determined by the prescriber.

Serious risks include severe bradycardia, marked hypotension, heart block, and rare allergic reactions such as anaphylaxis. Patients experiencing fainting, very slow heart rate, chest pain, or signs of an allergic response should seek immediate medical attention.

Isoptin Rr is contraindicated in patients with known hypersensitivity to verapamil or other calcium channel blockers, those with severe sinus bradycardia, second‑ or third‑degree AV block without a pacemaker, and individuals with cardiogenic shock. Clinicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.