Product image of Isoptin Rr Retard (Verapamil Hydrochloride) supplied by GNH India

Isoptin Rr Retard

Active Ingredient:
Verapamil Hydrochloride
Origin:
EU

Isoptin Rr Retard (Verapamil Hydrochloride)

Verapamil Hydrochloride, the active ingredient in Isoptin Rr Retard, is a calcium channel blocker presented as a prolonged‑release oral tablet for oral use. It is employed to lower high blood pressure, relieve chest pain from angina, and control certain cardiac rhythm disorders such as atrial fibrillation and supraventricular tachycardia in adult patients.

GNH India supplies Isoptin Rr Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, transplant centres and clinics worldwide, providing reliable quality and regulatory compliance.

Manufacturer / TM Owner

Viatris Austria Gmbh

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Indications & Clinical Uses

Verapamil is a calcium channel blocker used to manage cardiovascular conditions.

  • Hypertension: reduces systemic blood pressure by vasodilation of arterial smooth muscle.
  • Angina pectoris: alleviates chest pain by improving myocardial oxygen supply through coronary vasodilation.
  • Atrial fibrillation: helps control ventricular rate by slowing atrioventricular nodal conduction.
  • Supraventricular tachycardia: terminates episodes by reducing AV nodal conduction.

How It Works

  • Verapamil Hydrochloride blocks L‑type calcium channels in cardiac myocytes and vascular smooth‑muscle cells, decreasing intracellular calcium influx. This action reduces myocardial contractility, slows atrioventricular nodal conduction, and produces arterial vasodilation, collectively lowering blood pressure and stabilizing cardiac rhythm.

Side Effects

Common Side Effects

  • Constipation: reduced gastrointestinal motility.
  • Dizziness: transient orthostatic changes.
  • Headache: mild vascular headache.
  • Flushing: transient skin warmth.

Serious or Rare Side Effects

  • Severe bradycardia: markedly slowed heart rate.
  • Heart block: impaired AV nodal transmission.
  • Hypotension: significant drop in blood pressure.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Monitor blood pressure: ensure adequate control and avoid excessive hypotension.
  • Assess cardiac function: evaluate for existing conduction disorders.
  • Review concomitant beta‑blocker use: risk of additive AV block.
  • Adjust dose in hepatic impairment: reduced metabolism may increase exposure.
  • Avoid abrupt discontinuation: taper to prevent rebound hypertension.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Verapamil may interact with several medicines; awareness of the interaction level is essential.

Major Interactions (Avoid)

  • Beta‑blockers: additive AV nodal depression.
  • Digoxin: increased serum digoxin concentrations.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): elevated verapamil levels.

Moderate Interactions (Monitor Closely)

  • Amiodarone: potential increase in verapamil exposure.
  • ACE inhibitors: enhanced hypotensive effect.

Frequently Asked Questions

Isoptin Rr Retard, containing verapamil hydrochloride, is prescribed to treat high blood pressure, relieve angina pectoris, and manage certain cardiac rhythm disorders such as atrial fibrillation and supraventricular tachycardia in adult patients.

Verapamil blocks L‑type calcium channels in cardiac and vascular smooth‑muscle cells, reducing calcium entry. This leads to decreased myocardial contractility, slowed atrioventricular nodal conduction, and arterial vasodilation, which together lower blood pressure and stabilize heart rhythm.

The exact dosage of Isoptin Rr Retard is determined by the prescribing healthcare professional based on the patient’s condition, response to therapy, and other clinical factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of verapamil during pregnancy or lactation has not been definitively established. Healthcare providers should weigh potential benefits against possible risks and consider alternative therapies when appropriate. Women who are pregnant, planning pregnancy, or breastfeeding should discuss options with their physician.

To request Isoptin Rr Retard, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Isoptin Rr Retard (verapamil) is a non‑dihydropyridine calcium channel blocker, distinguished by its pronounced effects on cardiac conduction and contractility. Compared with dihydropyridine agents such as amlodipine, verapamil provides stronger rate‑control for arrhythmias but may cause more bradycardia and AV‑node slowing.

Store Isoptin Rr Retard at room temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Isoptin Rr Retard is taken orally, usually as a prolonged‑release tablet. It should be swallowed whole with a glass of water and taken at the same time each day, unless the prescriber advises otherwise.

Serious risks include severe bradycardia, heart block, and marked hypotension, which can be life‑threatening. Patients should be monitored for signs of these events, especially when initiating therapy or when combined with other agents that affect cardiac conduction.

Isoptin Rr Retard is contraindicated in patients with known hypersensitivity to verapamil, severe left ventricular dysfunction, advanced heart block without a pacemaker, and in those with uncontrolled heart failure. Clinicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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