Product image of Isoptin (Verapamil Hydrochloride) supplied by GNH India

Isoptin

Active Ingredient:
Verapamil Hydrochloride
Origin:
EU

Isoptin (Verapamil Hydrochloride)

Verapamil Hydrochloride, the active ingredient in Isoptin, is a calcium channel blocker presented as an intravenous solution for intravenous use. It treats hypertension, angina pectoris, atrial fibrillation and supraventricular tachycardia in adult patients.

GNH India supplies Isoptin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Manufacturer / TM Owner

Viatris Healthcare Gmbh

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Indications & Clinical Uses

  • Isoptin (verapamil hydrochloride) is used to manage cardiovascular conditions that involve abnormal cardiac rhythm or elevated vascular resistance.
  • Hypertension: lowers blood pressure by decreasing peripheral vascular resistance.
  • Angina pectoris: relieves chest pain by reducing myocardial oxygen demand.
  • Atrial fibrillation: controls ventricular rate by slowing atrioventricular conduction.
  • Supraventricular tachycardia: terminates tachycardic episodes by reducing conduction velocity.

How It Works

  • Verapamil hydrochloride inhibits L‑type calcium channels in cardiac myocytes and vascular smooth muscle, reducing calcium influx. This leads to decreased myocardial contractility, slowed conduction through the atrioventricular node, and lowered peripheral vascular resistance, thereby exerting anti‑arrhythmic and antihypertensive effects.

Side Effects

Adverse reactions may occur with intravenous verapamil administration.

Common Side Effects

  • Headache: mild to moderate headache may develop.
  • Flushing: transient warmth and redness of the skin.
  • Dizziness: light‑headed sensation, especially on standing.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure.
  • Bradycardia or heart block: markedly slowed heart rate or conduction block.
  • Allergic reaction: rash, itching, swelling, or anaphylaxis.

Precautions & Warnings

Careful monitoring is required when using Isoptin intravenously.

  • Monitor blood pressure: watch for excessive hypotension.
  • Monitor heart rate and ECG: detect bradycardia or AV block.
  • Use cautiously in heart failure: may worsen contractility.
  • Avoid in severe hepatic impairment: altered metabolism.
  • Adjust in renal impairment: consider accumulation.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Verapamil can interact with several medications; awareness of interaction severity is essential.

Major Interactions (Avoid)

  • Beta‑blockers: additive negative chronotropic effect.
  • Digoxin: increased risk of atrioventricular block.
  • CYP3A4 inhibitors (e.g., ketoconazole): elevated verapamil plasma levels.

Moderate Interactions (Monitor Closely)

  • Other calcium channel blockers (e.g., diltiazem): additive hypotension.
  • NSAIDs: may reduce antihypertensive efficacy.

Frequently Asked Questions

Isoptin, containing verapamil hydrochloride, is indicated for the intravenous management of hypertension, angina pectoris, atrial fibrillation, and supraventricular tachycardia. It is employed in adult patients when rapid control of blood pressure or cardiac rhythm is required.

Verapamil hydrochloride blocks L‑type calcium channels in cardiac and vascular smooth muscle. By reducing calcium entry, it decreases myocardial contractility, slows atrioventricular nodal conduction, and lowers peripheral vascular resistance, which together lower blood pressure and stabilize heart rhythm.

The specific dose of Isoptin is determined by the prescribing clinician based on the patient’s condition, severity, and response to therapy. Dosing regimens are individualized and should follow the prescriber’s instructions and local clinical guidelines.

Safety data for verapamil hydrochloride in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To order Isoptin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and required import documentation.

Isoptin (verapamil) is a non‑dihydropyridine calcium channel blocker, distinguished by its pronounced effects on cardiac conduction and contractility, making it useful for arrhythmia control. Dihydropyridine agents such as amlodipine primarily cause vasodilation with less impact on heart rate.

Store Isoptin at ambient temperature, preferably below 25 °C. Keep the vial in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly sealed to maintain sterility.

Isoptin is supplied as an intravenous solution and is administered directly into a vein by a qualified healthcare professional. The infusion rate and duration are set by the prescriber according to the clinical situation and patient response.

Serious risks include severe hypotension, marked bradycardia, atrioventricular block, and rare allergic reactions such as anaphylaxis. Patients should be monitored continuously for cardiovascular changes during and after infusion.

Isoptin is contraindicated in patients with known hypersensitivity to verapamil, severe hypotension, advanced heart block without a pacemaker, and those with uncompensated heart failure. Clinicians should assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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