Product image of Isoptin (Verapamil Hydrochloride) supplied by GNH India

Isoptin

Active Ingredient:
Verapamil Hydrochloride
Origin:
EU

Isoptin (Verapamil Hydrochloride)

Verapamil Hydrochloride, the active ingredient in Isoptin, is a calcium channel blocker presented as an intravenous solution for intravenous use. It reduces blood pressure, relieves chest pain from angina, and helps control supraventricular tachyarrhythmias such as atrial fibrillation in adult patients.

GNH India supplies Isoptin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, including Europe, Asia and the Americas, ensuring quality and regulatory conformity for global distribution. The company provides reliable logistics, regulatory support and documentation to facilitate import and clinical use.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Isoptin (verapamil hydrochloride) acts on calcium channels to manage cardiovascular conditions.

  • Hypertension: lowers systemic blood pressure by vasodilation.
  • Angina pectoris: reduces myocardial oxygen demand and improves coronary blood flow.
  • Supraventricular tachyarrhythmias: slows atrioventricular conduction to control heart rate in atrial fibrillation or flutter.

How It Works

  • Verapamil hydrochloride blocks L-type calcium channels in cardiac myocytes and vascular smooth muscle, decreasing intracellular calcium influx. This results in reduced myocardial contractility, slowed atrioventricular nodal conduction, and vasodilation of peripheral arteries, collectively lowering blood pressure and alleviating ischemic chest pain.

Side Effects

Adverse reactions may occur with intravenous verapamil administration.

Common Side Effects

  • Headache: mild to moderate pain in the head.
  • Flushing: sensation of warmth and redness.
  • Dizziness: light‑headed feeling.
  • Nausea: upset stomach.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure.
  • Bradycardia: abnormally slow heart rate.
  • Heart block: impaired electrical conduction.

Precautions & Warnings

Careful monitoring is required when using Isoptin.

  • Monitor blood pressure: check regularly during therapy.
  • Assess cardiac function: ECG monitoring for conduction changes.
  • Adjust dose in hepatic impairment: reduce dosage if liver function is compromised.
  • Caution in patients with heart failure: may worsen condition.
  • Avoid concomitant use with strong CYP3A4 inhibitors: may increase plasma levels.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Verapamil has several notable drug interactions.

Major Interactions (Avoid)

  • Concurrent use with beta‑blockers: risk of excessive bradycardia.
  • Combination with digoxin: increased risk of toxicity.
  • Co‑administration with strong CYP3A4 inhibitors (e.g., ketoconazole): may cause severe hypotension.

Moderate Interactions (Monitor Closely)

  • Use with diltiazem: additive AV‑node effects.
  • Interaction with statins metabolized by CYP3A4: may raise statin levels.
  • Concomitant use with diuretics: may enhance hypotensive effect.

Frequently Asked Questions

Isoptin contains verapamil hydrochloride and is used intravenously to treat hypertension, relieve angina pectoris, and manage supraventricular tachyarrhythmias such as atrial fibrillation or flutter in adult patients.

Verapamil blocks L-type calcium channels in cardiac and vascular smooth muscle, decreasing calcium entry. This reduces myocardial contractility, slows AV‑node conduction, and causes peripheral vasodilation, which together lower blood pressure and lessen cardiac workload.

The dose of Isoptin is determined by the prescribing healthcare professional based on the patient’s clinical condition, response to therapy, and any relevant laboratory parameters. No fixed regimen is provided here.

The pregnancy category for verapamil hydrochloride is not definitively established. Use during pregnancy or lactation should only occur when clearly needed and after consultation with a qualified healthcare provider.

To order Isoptin, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Isoptin (verapamil) is a non‑dihydropyridine calcium channel blocker, primarily affecting cardiac conduction and contractility, whereas dihydropyridine agents (e.g., amlodipine) mainly cause peripheral vasodilation. Verapamil is therefore preferred when rate control of arrhythmias is needed, while dihydropyridines are often chosen for isolated hypertension.

Isoptin should be stored at 2‑8 °C, kept refrigerated, protected from light, and should not be frozen or shaken. Use aseptic technique when preparing the intravenous solution and discard any unused portion after the recommended in‑use period.

Isoptin is administered by intravenous infusion under the supervision of a qualified healthcare professional. The infusion rate and duration are set by the prescriber, and patients are monitored for blood pressure, heart rate and any adverse reactions throughout the administration.

Serious risks include severe hypotension, marked bradycardia, and heart block, which can lead to syncope or cardiac arrest. Prompt recognition and management are essential, and patients should be monitored continuously during intravenous infusion.

Isoptin is contraindicated in patients with known hypersensitivity to verapamil or other calcium channel blockers, those with severe hypotension, advanced heart block without a pacemaker, and in patients with certain types of cardiogenic shock. Clinical judgment is required for other special populations.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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