Product image of Isoptin (Verapamil Hydrochloride) supplied by GNH India

Isoptin

Active Ingredient:
Verapamil Hydrochloride
Origin:
EU

Isoptin (Verapamil Hydrochloride)

Verapamil, the active ingredient in Isoptin, is a calcium channel blocker presented as an oral tablet for oral use. It is employed to manage high blood pressure, chest pain due to angina, and certain cardiac rhythm disorders in adult patients, and is commonly prescribed by cardiologists and primary care physicians.

GNH India supplies Isoptin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to support global distribution.

Manufacturer / TM Owner

Viatris Austria Gmbh

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Isoptin (verapamil) is used to treat conditions related to cardiovascular pressure regulation and cardiac electrical activity.
  • Hypertension: helps lower systemic arterial pressure by causing vasodilation of peripheral blood vessels, thereby reducing cardiac workload.
  • Angina pectoris: diminishes frequency and severity of chest pain by decreasing myocardial oxygen consumption through reduced contractility and heart rate.
  • Supraventricular tachycardia and other cardiac arrhythmias: controls abnormal rapid heart rhythms by slowing conduction through the atrioventricular node and extending refractory periods.
  • Atrial fibrillation: assists in rate control by reducing ventricular response through AV nodal blockade, improving symptoms and preventing tachycardia-mediated cardiomyopathy.

How It Works

  • Verapamil blocks L-type calcium channels in cardiac and smooth muscle cells, decreasing intracellular calcium influx. This results in reduced myocardial contractility, slowed atrioventricular nodal conduction, and vasodilation of peripheral arteries, collectively lowering blood pressure and alleviating cardiac workload.

Side Effects

Verapamil may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Constipation: reduced gastrointestinal motility leading to hard stools.
  • Dizziness: transient light‑headedness often related to blood pressure changes.
  • Headache: mild to moderate pain commonly reported during therapy initiation.
  • Peripheral edema: swelling of ankles or lower limbs due to vasodilation.
  • Nausea: upset stomach with possible vomiting.
  • Flushing: transient warmth and reddening of skin.

Serious or Rare Side Effects

  • Severe bradycardia: markedly slowed heart rate that may require medical attention.
  • Heart block: impairment of electrical conduction between atria and ventricles.
  • Hypotension: significant drop in blood pressure causing faintness or shock.

Precautions & Warnings

Before initiating verapamil therapy, clinicians should consider several safety aspects.

  • Cardiovascular monitoring: assess heart rate and blood pressure before and during therapy.
  • Conduction disorders: avoid in patients with existing AV block unless paced.
  • Liver impairment: use with caution; dose adjustment may be required.
  • Drug interactions: review concomitant medications for CYP3A4 substrates.
  • Pregnancy and lactation: safety not established; prescribe only if benefits outweigh risks.
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture.

Avoid Interactions

Verapamil interacts with several medicines; careful review is essential.

Major Interactions (Avoid)

  • Beta‑blockers: combined use may cause excessive bradycardia or AV block.
  • Digoxin: increased serum levels leading to toxicity.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): raise verapamil concentrations.
  • Macrolide antibiotics (e.g., erythromycin): may increase plasma levels.

Moderate Interactions (Monitor Closely)

  • Diltiazem: additive effects on cardiac conduction.
  • Rifampin: may reduce verapamil effectiveness.
  • NSAIDs: can diminish antihypertensive effect.
  • Calcium supplements: may reduce absorption; separate dosing by at least 2 hours.
  • Other antihypertensives: monitor for additive blood pressure lowering.

Frequently Asked Questions

Isoptin, which contains verapamil, is prescribed for high blood pressure (hypertension), chest pain caused by angina pectoris, and certain cardiac rhythm disorders such as supraventricular tachycardia and atrial fibrillation. It works by relaxing blood vessels and slowing electrical conduction in the heart.

Verapamil blocks L-type calcium channels in cardiac muscle and vascular smooth muscle. By reducing calcium entry, it decreases heart muscle contractility, slows conduction through the atrioventricular node, and causes vasodilation of peripheral arteries, which together lower blood pressure and relieve angina.

The appropriate dose of Isoptin is determined by the prescribing clinician based on the patient’s specific condition, response to therapy, and any other medications being taken. Dosage may be adjusted over time to achieve the desired therapeutic effect while minimizing side effects.

Safety data for verapamil in pregnancy and lactation are limited. It should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers will evaluate each case individually.

To request Isoptin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Isoptin (verapamil) is a non‑dihydropyridine calcium channel blocker, primarily affecting cardiac conduction and contractility, whereas agents like amlodipine are dihydropyridines that mainly cause peripheral vasodilation. Choice of agent depends on the clinical indication, patient comorbidities and physician preference.

Store Isoptin tablets at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Isoptin is taken orally, usually with a glass of water. The tablet should be swallowed whole and not chewed or crushed unless specifically instructed by a healthcare professional. Dosing times (e.g., with or without food) are determined by the prescriber.

Serious adverse events can include severe bradycardia, heart block, and marked hypotension. Patients should be monitored for signs of these conditions, especially when initiating therapy or when combined with other drugs that affect heart rate or blood pressure.

Isoptin is contraindicated in patients with known hypersensitivity to verapamil, severe hypotension, uncorrected heart block, or cardiogenic shock. It should also be used with caution in individuals with severe liver impairment or certain conduction disorders unless a pacemaker is in place.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Verapamil Hydrochloride

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT