Product image of Isoptin (Verapamil Hydrochloride) supplied by GNH India

Isoptin

Active Ingredient:
Verapamil Hydrochloride
Origin:
EU

Isoptin (Verapamil Hydrochloride)

Verapamil, the active ingredient in Isoptin, is a calcium channel blocker presented as an oral tablet for oral use. It is employed to manage high blood pressure, relieve chest pain from angina, and control certain cardiac rhythm disorders in adult patients.

GNH India supplies Isoptin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand. Clients benefit from reliable logistics, comprehensive documentation, and responsive technical support throughout the procurement process.

Manufacturer / TM Owner

Pliva Hrvatska D.O.O.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Isoptin (verapamil) acts on the cardiovascular system to lower blood pressure, relieve angina, and stabilize heart rhythm.
  • Hypertension: reduces systemic vascular resistance and lowers arterial pressure.
  • Angina pectoris: decreases myocardial oxygen demand by reducing cardiac contractility and heart rate.
  • Cardiac arrhythmias: slows conduction through the atrioventricular node to control supraventricular tachycardia.

How It Works

  • Verapamil blocks L‑type calcium channels in cardiac myocytes and vascular smooth muscle. By inhibiting calcium influx, it reduces myocardial contractility, slows atrioventricular nodal conduction, and promotes vasodilation of arterial vessels, leading to decreased heart rate, lowered blood pressure, and reduced myocardial oxygen consumption. The drug’s effect on the sinoatrial node also contributes to heart‑rate control, while its action on peripheral arteries improves coronary blood flow.

Side Effects

Verapamil may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Constipation
  • Dizziness
  • Headache
  • Flushing
  • Peripheral edema
  • Nausea

Serious or Rare Side Effects

  • Severe bradycardia
  • Heart block
  • Marked hypotension
  • Atrioventricular conduction disturbances
  • Allergic reactions
  • Elevated liver enzymes

Precautions & Warnings

Before prescribing Isoptin, clinicians should consider several safety measures.

  • Monitor blood pressure: check regularly to avoid excessive hypotension.
  • Assess cardiac function: evaluate for existing conduction abnormalities.
  • Review concomitant beta‑blocker therapy: combined use may increase bradycardia risk.
  • Use with caution in hepatic impairment: dose adjustment may be required.
  • Avoid abrupt discontinuation: taper to prevent rebound hypertension.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Verapamil can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Diltiazem: additive cardiac depressant effects.
  • Beta‑blockers: increased risk of bradycardia and AV block.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may raise verapamil plasma levels.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may reduce antihypertensive efficacy.
  • Statins: potential for increased statin concentrations.

Frequently Asked Questions

Isoptin (verapamil) is prescribed for hypertension, angina pectoris, and certain cardiac arrhythmias such as supraventricular tachycardia. It helps lower blood pressure, relieve chest pain, and control abnormal heart rhythms.

Verapamil blocks L‑type calcium channels in cardiac and vascular smooth muscle, reducing calcium entry. This decreases myocardial contractility, slows atrioventricular nodal conduction, and causes arterial vasodilation, resulting in lower heart rate, blood pressure, and oxygen demand.

The appropriate dose of Isoptin is determined by the prescribing clinician based on the patient’s condition, response, and other medications. Dosage may be adjusted during treatment to achieve therapeutic goals.

Safety of verapamil in pregnancy or lactation has not been fully established. It should only be used if the potential benefit justifies any possible risk, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the Isoptin product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and required import documentation.

Compared with dihydropyridine agents such as amlodipine, verapamil has a stronger effect on cardiac conduction and contractility, making it useful for arrhythmia control, while dihydropyridines primarily cause vasodilation. Choice depends on the clinical indication and patient profile.

Store Isoptin at room temperature, below 25 °C, in the original packaging. Protect the tablets from moisture and direct sunlight to maintain stability.

Isoptin is taken orally, usually with a glass of water. It may be taken with or without food, as directed by the prescriber. Swallow the tablet whole; do not crush or chew unless instructed.

Serious adverse effects can include severe bradycardia, heart block, marked hypotension, and atrioventricular conduction disturbances. Patients should be monitored for these events, especially when initiating therapy or adjusting dose.

Isoptin is contraindicated in patients with known hypersensitivity to verapamil, severe hypotension, advanced heart block without a pacemaker, and in those with cardiogenic shock. Caution is also advised in severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Verapamil Hydrochloride

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT