Product image of Isoptin (Verapamil Hydrochloride) supplied by GNH India

Isoptin

Active Ingredient:
Verapamil Hydrochloride
Origin:
EU

Isoptin (Verapamil Hydrochloride)

Verapamil Hydrochloride, the active ingredient in Isoptin, is a calcium channel blocker presented as an oral tablet for oral use. It is employed to manage high blood pressure, chest pain and certain heart rhythm disorders in adult patients.
GNH India supplies Isoptin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Healthcare Gmbh

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Isoptin is a calcium channel blocker used in cardiovascular conditions that involve elevated vascular tone or abnormal cardiac conduction.
  • Hypertension: lowers blood pressure by relaxing arterial smooth muscle.
  • Angina pectoris: reduces myocardial oxygen demand through vasodilation and decreased contractility.
  • Atrial fibrillation: helps control ventricular rate by slowing atrioventricular conduction.
  • Supraventricular tachycardia: terminates episodes by inhibiting rapid atrial impulses.

How It Works

  • Verapamil Hydrochloride blocks L‑type calcium channels on cardiac myocytes and vascular smooth‑muscle cells, decreasing intracellular calcium influx. This results in reduced myocardial contractility, slowed atrioventricular nodal conduction, and vasodilation of peripheral arteries, collectively lowering blood pressure and stabilising cardiac rhythm.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Constipation: reduced gastrointestinal motility.
  • Dizziness or light‑headedness: related to blood pressure lowering.
  • Headache: often mild and transient.
  • Flushing: due to peripheral vasodilation.

Serious or Rare Side Effects

  • Bradycardia or heart block: excessive slowing of cardiac conduction.
  • Severe hypotension: marked drop in blood pressure.
  • Hepatic dysfunction: abnormal liver enzymes or hepatitis.
  • Allergic reactions: rash, angioedema, or anaphylaxis.
  • Cardiac failure exacerbation: worsening of pre‑existing heart failure.

Precautions & Warnings

  • Before initiating therapy, clinicians should evaluate cardiovascular status and potential risk factors.
  • Monitor blood pressure: adjust dose if hypotension occurs.
  • Assess cardiac conduction: obtain ECG to detect pre‑existing AV block.
  • Use caution in hepatic impairment: metabolism may be reduced.
  • Avoid abrupt discontinuation: taper to prevent rebound hypertension.
  • Review concomitant beta‑blocker use: increased risk of bradycardia.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Verapamil can interact with several medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Concurrent beta‑blockers: additive bradycardia and AV block.
  • Digoxin: increased serum digoxin levels, risk of toxicity.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): elevated verapamil concentrations.

Moderate Interactions (Monitor Closely)

  • Diltiazem: additive effects on cardiac conduction.
  • Amiodarone: may increase verapamil levels.
  • Macrolide antibiotics (e.g., erythromycin): moderate CYP3A4 inhibition.
  • Diuretics: enhanced hypotensive effect.
  • NSAIDs: may reduce antihypertensive response.

Frequently Asked Questions

Isoptin, containing verapamil hydrochloride, is prescribed for hypertension, angina pectoris, atrial fibrillation, and supraventricular tachycardia. It helps lower blood pressure, relieve chest pain, and control abnormal heart rhythms by acting on calcium channels in the heart and blood vessels.

Verapamil blocks L‑type calcium channels on cardiac and vascular smooth‑muscle cells. This reduces calcium entry, leading to decreased heart muscle contractility, slowed atrioventricular nodal conduction, and dilation of peripheral arteries, which together lower blood pressure and stabilize heart rhythm.

The specific dose of Isoptin is determined by the prescribing clinician based on the patient’s condition, response, and other medical factors. Dosage may be adjusted over time, and patients should follow the exact instructions provided by their healthcare professional.

Safety data for verapamil during pregnancy and lactation are limited. Healthcare providers usually weigh potential benefits against possible risks before prescribing it to pregnant or nursing women. Patients should discuss any concerns with their physician.

To request Isoptin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Isoptin (verapamil) is a non‑dihydropyridine calcium channel blocker, distinguished by its pronounced effects on cardiac conduction and contractility. In contrast, dihydropyridine agents such as amlodipine primarily cause vasodilation with minimal impact on heart rate, making verapamil preferable for certain arrhythmias.

Isoptin should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and excessive heat to maintain stability and potency.

Isoptin is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless directed by a healthcare professional. Dosing times (e.g., with or without food) are determined by the prescriber.

Serious risks include severe bradycardia, heart block, marked hypotension, hepatic dysfunction, and rare allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience fainting, rapid weight gain, jaundice, or signs of an allergic response.

Isoptin is contraindicated in patients with known hypersensitivity to verapamil, severe hypotension, advanced heart block without a pacemaker, and certain forms of cardiogenic shock. Individuals with uncontrolled heart failure or significant hepatic impairment should also avoid its use unless closely monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Verapamil Hydrochloride

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT