Product image of Isoptin (Verapamil Hydrochloride) supplied by GNH India

Isoptin

Active Ingredient:
Verapamil Hydrochloride
Origin:
EU

Isoptin (Verapamil Hydrochloride)

Verapamil Hydrochloride, the active ingredient in Isoptin, is a calcium channel blocker presented as an oral tablet for oral administration. It is indicated for the management of hypertension, angina pectoris, and selected supraventricular tachyarrhythmias such as atrial fibrillation and atrial flutter in adult patients.

GNH India supplies Isoptin as a licensed, GDP‑compliant international pharmaceutical product, providing reliable sourcing to hospitals, pharmacies, and clinics across global markets. The company adheres to European Union quality standards and supports procurement teams with regulatory documentation, shipping logistics, and post‑supply services.

Manufacturer / TM Owner

Viatris Healthcare Lda.

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Indications & Clinical Uses

Isoptin (verapamil) acts on the cardiovascular system by modulating calcium influx, and is used for the following conditions:

  • Hypertension: lowers blood pressure through peripheral vasodilation.
  • Angina pectoris: reduces myocardial oxygen demand and relieves chest pain.
  • Supraventricular tachyarrhythmias: controls heart rate and helps restore normal rhythm in atrial fibrillation and atrial flutter.

How It Works

  • Verapamil Hydrochloride blocks L‑type calcium channels in cardiac and vascular smooth muscle cells. By inhibiting calcium entry, it decreases myocardial contractility, slows conduction through the atrioventricular node, and promotes peripheral vasodilation, leading to lowered blood pressure and reduced cardiac workload. The drug also prolongs the refractory period of cardiac tissue, contributing to its antiarrhythmic properties. In the AV node, verapamil reduces the slope of phase 4 depolarization, thereby decreasing impulse transmission.

Side Effects

Verapamil may cause a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Headache: mild to moderate headache.
  • Dizziness: sensation of light‑headedness.
  • Peripheral edema: swelling of ankles or feet.

Serious or Rare Side Effects

  • Bradycardia: dangerously slow heart rate.
  • Heart block: impaired AV‑node conduction.
  • Severe hypotension: marked drop in blood pressure.

Precautions & Warnings

When prescribing Isoptin, clinicians should consider several precautionary measures.

  • Dose adjustment: required in hepatic impairment.
  • Renal function: monitor in severe renal failure.
  • Concomitant beta‑blockers: increased risk of bradycardia.
  • Pregnancy: use only if clearly needed after risk assessment.
  • Drug interactions: review all concomitant medications.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Verapamil interacts with several medicines; careful assessment is essential.

Major Interactions (Avoid)

  • Beta‑blockers: additive bradycardia and AV block.
  • CYP3A4 inhibitors (e.g., ketoconazole): increased verapamil levels.
  • Digoxin: heightened risk of digoxin toxicity.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin): reduced verapamil efficacy.
  • Aspirin and NSAIDs: may blunt antihypertensive effect.
  • Statins metabolized by CYP3A4: increased statin exposure, risk of myopathy.

Frequently Asked Questions

Isoptin contains verapamil hydrochloride and is prescribed to treat high blood pressure, relieve chest pain from angina, and manage certain supraventricular tachyarrhythmias such as atrial fibrillation and atrial flutter in adult patients.

Verapamil blocks L‑type calcium channels in heart and vascular smooth‑muscle cells, reducing calcium influx. This leads to decreased myocardial contractility, slowed AV‑node conduction, and peripheral vasodilation, which together lower blood pressure and help control abnormal heart rhythms.

The appropriate dose of Isoptin is individualized by the prescribing clinician based on the patient’s specific condition, response to therapy, and any relevant organ‑function considerations. No fixed regimen is provided here.

Safety data for verapamil during pregnancy and lactation are limited. Use is generally reserved for situations where the potential benefit justifies any potential risk to the fetus or infant, and decisions should be made in consultation with a healthcare professional.

To request Isoptin, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Isoptin (verapamil) belongs to the calcium‑channel blocker class, offering rate‑control benefits similar to diltiazem but with a stronger effect on vascular tone. Compared with beta‑blockers, it may be preferred when bronchospasm risk is a concern, though each class has distinct efficacy and safety profiles that guide selection.

Isoptin should be stored at ambient temperature, preferably below 25 °C, in its original packaging. Keep the product away from excess moisture, direct sunlight, and heat sources to maintain its stability.

Isoptin is taken orally as a tablet. It can be swallowed with or without food, but patients should follow the prescribing clinician’s instructions regarding timing and any dietary considerations.

The most concerning adverse events include marked bradycardia, heart block, and severe hypotension. Patients should seek immediate medical attention if they experience fainting, unusually slow heart rate, or a sudden drop in blood pressure.

Isoptin is contraindicated in patients with known severe sinus‑node dysfunction, second‑ or third‑degree AV block without a pacemaker, uncontrolled heart failure, or a history of hypersensitivity to verapamil or other calcium‑channel blockers.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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