Product image of Isoptine (Verapamil Hydrochloride) supplied by GNH India

Isoptine

Active Ingredient:
Verapamil Hydrochloride
Origin:
EU

Isoptine (Verapamil Hydrochloride)

Verapamil Hydrochloride, the active ingredient in Isoptine, is a calcium channel blocker presented as an oral tablet for oral use. It is employed to manage high blood pressure, chest pain due to angina, and certain cardiac rhythm disturbances in adult patients.

GNH India supplies Isoptine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for export to EU and other markets. Customers benefit from reliable lead times and comprehensive technical support.

Manufacturer / TM Owner

Viatris Healthcare Nv/Sa

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Indications & Clinical Uses

  • Isoptine, a calcium channel blocker, is indicated for several cardiovascular conditions.
  • Hypertension: Reduces systemic vascular resistance to lower blood pressure.
  • Angina pectoris: Improves myocardial oxygen supply by decreasing cardiac workload.
  • Cardiac arrhythmias: Controls ventricular rate in supraventricular tachyarrhythmias.

How It Works

  • Verapamil Hydrochloride selectively inhibits L‑type calcium channels in cardiac myocytes and vascular smooth muscle. By reducing calcium influx, it decreases myocardial contractility, slows atrioventricular nodal conduction, and dilates peripheral arteries, leading to lower heart rate, reduced cardiac output, and decreased peripheral vascular resistance. These actions collectively contribute to its antihypertensive, anti‑anginal, and anti‑arrhythmic effects and improve coronary blood flow in patients.

Side Effects

Verapamil Hydrochloride may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Constipation: Reduced gastrointestinal motility.
  • Dizziness: Transient light‑headedness.
  • Headache: Mild to moderate intensity.
  • Flushing: Warm sensation and skin reddening.
  • Peripheral edema: Swelling of lower limbs.
  • Nausea: Stomach upset.

Serious or Rare Side Effects

  • Bradycardia: Markedly slowed heart rate.
  • Hypotension: Significant drop in blood pressure.
  • Atrioventricular block: Impaired conduction between atria and ventricles.
  • Heart failure exacerbation: Worsening of existing cardiac insufficiency.
  • Severe allergic reaction: Anaphylaxis or angioedema.
  • Liver enzyme elevation: Hepatotoxicity signs.

Precautions & Warnings

Before initiating Isoptine, clinicians should consider several safety measures to minimize risk.

  • Blood pressure monitoring: Check baseline and periodic readings.
  • Cardiac function assessment: Evaluate for existing heart block or heart failure.
  • Concomitant beta‑blocker use: Adjust dose to avoid excessive bradycardia.
  • Hepatic impairment: Use lower doses and monitor liver tests.
  • Severe hypotension: Contraindicated in patients with markedly low blood pressure.
  • Store at room temperature: Keep in the original container, protect from moisture and light.

Avoid Interactions

Verapamil Hydrochloride interacts with several medicines; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid)

  • Beta‑blockers: Additive negative chronotropic effect may cause severe bradycardia.
  • Digoxin: Increases serum digoxin concentrations, raising toxicity risk.
  • Diltiazem: Combined calcium channel blockade can lead to profound hypotension.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): Elevate verapamil levels, increasing adverse effect potential.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin): Reduce verapamil exposure, diminishing efficacy.
  • ACE inhibitors or ARBs: May enhance antihypertensive effect, requiring blood pressure monitoring.
  • Statins metabolized by CYP3A4 (e.g., simvastatin): Increased risk of statin‑related muscle toxicity.

Frequently Asked Questions

Isoptine contains verapamil hydrochloride, a calcium channel blocker that is prescribed to treat high blood pressure (hypertension), relieve chest pain caused by angina, and manage certain abnormal heart rhythms such as supraventricular tachycardia.

Verapamil blocks L‑type calcium channels in the heart and blood‑vessel walls. This reduces calcium entry into cells, leading to lower heart‑muscle contractility, slower conduction through the atrioventricular node, and dilation of peripheral arteries, which together lower blood pressure and cardiac workload.

The appropriate dose of Isoptine is determined by the prescribing clinician based on the patient’s condition, age, kidney and liver function, and response to therapy. Dosage may be adjusted during treatment to achieve the desired therapeutic effect while minimizing side effects.

Safety data for verapamil during pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified health‑care professional.

To place an order, submit an enquiry on the Isoptine product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Isoptine (verapamil) is a non‑dihydropyridine calcium channel blocker, similar to diltiazem. Both reduce heart rate and contractility, but verapamil has a stronger effect on cardiac conduction, making it preferable for certain arrhythmias, whereas diltiazem may be chosen when a milder impact on heart rate is desired.

Isoptine tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Isoptine is taken orally as a tablet. Patients should swallow the tablet whole with a glass of water, with or without food, unless otherwise directed by their prescriber. The exact timing and frequency are set by the treating physician.

Serious adverse events include marked bradycardia, severe hypotension, atrioventricular block, and worsening of existing heart failure. Patients should seek immediate medical attention if they experience fainting, very slow heartbeat, chest pain, or sudden swelling of the legs.

Isoptine is contraindicated in patients with severe hypotension, advanced heart block (second‑ or third‑degree), cardiogenic shock, or known hypersensitivity to verapamil or any excipients. Caution is also advised in individuals with severe liver impairment or uncontrolled heart failure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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