Product image of Isopto B12 (Cyanocobalamin) supplied by GNH India

Isopto B12

Active Ingredient:
Cyanocobalamin
Origin:
EU

Isopto B12 (Cyanocobalamin)

Cyanocobalamin, the active ingredient in Isopto B12, is a Vitamin B12 presented as an ocular solution for eye use. It supports ocular surface health and may be used in patients with vitamin B12‑related eye conditions.

GNH India supplies Isopto B12 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Reva Health Europe S.L.

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Indications & Clinical Uses

Isopto B12 is a vitamin B12 ocular preparation used to address conditions affecting the ocular surface.

  • Dry eye syndrome: helps alleviate discomfort and improve tear film stability.
  • Neurotrophic keratitis: supports corneal healing in patients with reduced corneal sensitivity.
  • Post‑surgical ocular surface recovery: may aid regeneration after refractive or cataract surgery.

How It Works

  • Cyanocobalamin acts as a cofactor for methionine synthase and other enzymes involved in cellular methylation and DNA synthesis. In ocular tissues, it contributes to epithelial cell proliferation, reduces oxidative stress, and supports the maintenance of a healthy corneal and conjunctival surface.

Side Effects

Isopto B12 may cause local ocular reactions.

Common Side Effects

  • Stinging or burning sensation upon instillation.
  • Transient redness of the conjunctiva.
  • Mild eye irritation or foreign‑body feeling.
  • Temporary blurred vision that clears quickly.
  • Mild tearing.
  • Slight itching.

Serious or Rare Side Effects

  • Allergic reaction presenting as swelling, rash, or severe itching.
  • Persistent corneal epithelial defect.
  • Vision loss not attributable to underlying disease.
  • Severe ocular inflammation.
  • Anaphylaxis (extremely rare).

Precautions & Warnings

Before using Isopto B12, consider the following precautions.

  • Allergy assessment: avoid if known hypersensitivity to cyanocobalamin or formulation excipients.
  • Contact lens wearers: remove lenses before instillation and wait before reinserting.
  • Concomitant ocular medications: monitor for reduced efficacy or irritation.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Pediatric use: safety not established; use only if prescribed.
  • Store at room temperature below 25°C: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Isopto B12 may interact with other agents.

Major Interactions (Avoid)

  • Systemic metformin therapy: may reduce overall vitamin B12 levels, potentially diminishing ocular benefit.
  • High‑dose oral cyanocobalamin: concurrent use may lead to excess systemic B12.

Moderate Interactions (Monitor Closely)

  • Topical antibiotics: monitor for reduced antimicrobial activity.
  • Anti‑inflammatory eye drops: assess for additive irritation.
  • Preservative‑containing drops: watch for cumulative preservative load.
  • Other ocular vitamins: evaluate combined effect on ocular surface.
  • Systemic proton‑pump inhibitors: may affect B12 absorption, though ocular impact is minimal.

Frequently Asked Questions

Isopto B12 is an ocular formulation of cyanocobalamin used to support the health of the ocular surface. It is commonly employed in conditions such as dry eye syndrome, neurotrophic keratitis, and to aid healing after eye surgery.

Cyanocobalamin serves as a cofactor for enzymes involved in DNA synthesis and cellular methylation. In the eye, it promotes epithelial cell proliferation, reduces oxidative stress, and helps maintain a stable tear film, contributing to overall ocular surface integrity.

The dosing regimen for Isopto B12 is determined by the prescribing clinician based on the specific indication, severity of the condition, and patient factors. The prescriber will provide the appropriate number of drops and frequency.

Safety data for ocular cyanocobalamin during pregnancy and lactation are limited. Healthcare professionals should evaluate the risk‑benefit profile before prescribing Isopto B12 to pregnant or nursing individuals.

To order Isopto B12, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Isopto B12 contains cyanocobalamin, the most widely studied form of vitamin B12 for ocular use. Compared with other formulations, it offers a standardized concentration and is manufactured under EU GMP standards, ensuring consistent potency and purity.

Store Isopto B12 at room temperature below 25 °C. Keep the container tightly closed, protect it from moisture and direct sunlight, and retain it in the original packaging until use.

Isopto B12 is applied as eye drops. The patient should wash hands, tilt the head back, pull down the lower eyelid, instill the prescribed number of drops, and close the eye gently for a few seconds. Contact lenses should be removed before administration.

Serious risks, though rare, include allergic reactions such as swelling, rash, or severe itching, and persistent corneal epithelial defects. Any signs of severe eye irritation, vision changes, or systemic allergic response should prompt immediate medical attention.

Individuals with known hypersensitivity to cyanocobalamin or any component of the formulation should avoid using Isopto B12. It is also not recommended for pediatric patients unless specifically prescribed by a qualified eye care professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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