Product image of Isosorbide-5-Mononitrate Aurobindo (Isosorbide 5 Mononitrate) supplied by GNH India

Isosorbide-5-Mononitrate Aurobindo

Active Ingredient:
Isosorbide 5 Mononitrate
Origin:
EU

Isosorbide-5-Mononitrate Aurobindo (Isosorbide 5 Mononitrate)

Isosorbide 5-Mononitrate, the active ingredient in Isosorbide-5-Mononitrate Aurobindo, is an organic nitrate presented as an oral tablet for oral use. It is employed to manage chronic stable angina and angina pectoris in adult patients who require long‑term anti‑anginal therapy.

GNH India supplies Isosorbide-5-Mononitrate Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurobindo Pharma B.V.

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Indications & Clinical Uses

Isosorbide 5-Mononitrate belongs to the organic nitrate class and is used to treat conditions related to myocardial oxygen demand.

  • Chronic stable angina: reduces the frequency and severity of angina attacks during daily activities.
  • Angina pectoris: alleviates chest pain caused by transient myocardial ischemia.
  • Exercise‑induced angina: improves exercise tolerance by decreasing cardiac preload and afterload.

How It Works

  • Isosorbide 5-Mononitrate is a prodrug that is metabolized to release nitric oxide (NO) in vascular smooth muscle. NO activates guanylate cyclase, increasing cyclic GMP levels, which leads to relaxation of smooth muscle, vasodilation of veins and arteries, and a consequent reduction in cardiac preload and afterload, improving myocardial oxygen balance.

Side Effects

Isosorbide 5-Mononitrate may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Headache: often transient and related to vasodilation.
  • Dizziness or light‑headedness: due to lowered blood pressure.
  • Flushing: warm sensation, especially on the face.
  • Nausea or abdominal discomfort.
  • Palpitations or tachycardia.
  • Hypotension: mild drop in blood pressure.

Serious or Rare Side Effects

  • Severe hypotension leading to syncope.
  • Myocardial infarction in susceptible patients.
  • Allergic reactions such as rash, pruritus, or angioedema.
  • Methemoglobinemia (rare).
  • Life‑threatening arrhythmias.
  • Persistent severe headache unresponsive to treatment.

Precautions & Warnings

When prescribing or dispensing Isosorbide 5-Mononitrate, consider the following safety measures.

  • Cardiovascular assessment: evaluate blood pressure and cardiac status before initiation.
  • Concomitant nitrates: avoid using with other nitrate preparations to prevent excessive hypotension.
  • Phosphodiesterase‑5 inhibitors: do not combine with sildenafil, tadalafil, or similar agents.
  • Hepatic impairment: monitor and adjust dose if liver function is compromised.
  • Abrupt discontinuation: taper the dose to reduce the risk of rebound angina.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Isosorbide 5-Mononitrate can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Other organic nitrates or nitroglycerin: additive vasodilatory effect may cause severe hypotension.
  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil, tadalafil): risk of profound blood pressure fall.
  • Guanylate cyclase stimulators: synergistic vasodilation.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents (ACE inhibitors, beta‑blockers, diuretics): may enhance blood‑pressure‑lowering effect.
  • Alcohol: can increase vasodilatory response and dizziness.
  • Smoking: induces hepatic metabolism, potentially reducing drug efficacy.
  • Antacids containing aluminum or magnesium: may affect absorption timing.

Frequently Asked Questions

Isosorbide-5-Mononitrate is used to prevent and treat episodes of chest pain (angina) in patients with chronic stable angina or angina pectoris. By dilating blood vessels, it reduces the workload on the heart and improves oxygen delivery during physical activity.

The drug is a prodrug that releases nitric oxide after oral absorption. Nitric oxide activates guanylate cyclase in vascular smooth muscle, raising cyclic GMP levels, which cause relaxation of veins and arteries. This lowers cardiac preload and afterload, decreasing myocardial oxygen demand.

The specific dose and dosing schedule are determined by the prescribing clinician based on the patient’s condition, response, and tolerability. Dosage forms and strengths may vary, and the prescriber will tailor the regimen to each individual.

Safety data for use in pregnancy and lactation are limited. The product is classified as pregnancy category unknown, and it should only be used if the potential benefit justifies any potential risk to the fetus. Breastfeeding mothers should consult their healthcare provider before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with beta‑blockers or calcium‑channel blockers, Isosorbide-5-Mononitrate provides rapid vasodilation and is particularly useful for patients who need nitrate therapy or who have contraindications to other classes. However, tolerance can develop with continuous use, so drug‑free intervals are often recommended.

Store the tablets at room temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

The medication is taken orally, usually with a glass of water. It may be prescribed as a single daily dose or divided doses, depending on the formulation and the prescriber’s instructions. Patients should follow the exact schedule provided by their healthcare professional.

Serious risks include severe hypotension, syncope, myocardial infarction, life‑threatening arrhythmias, and rare allergic reactions such as angioedema. Patients should seek immediate medical attention if they experience fainting, chest pain, or signs of an allergic response.

Patients with known hypersensitivity to isosorbide mononitrate or any other organic nitrates should avoid the drug. It is also contraindicated in individuals taking other nitrate preparations or phosphodiesterase‑5 inhibitors due to the risk of severe hypotension.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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