Product image of Isosorbide Mononitrate Accord Healthcare (Isosorbide Mononitrate) supplied by GNH India

Isosorbide Mononitrate Accord Healthcare

Active Ingredient:
Isosorbide Mononitrate
Origin:
EU

Isosorbide Mononitrate Accord Healthcare (Isosorbide Mononitrate)

Isosorbide Mononitrate, the active ingredient in Isosorbide Mononitrate Accord Healthcare, is an organic nitrate presented as an oral tablet for oral use. It is employed to prevent episodes of chest pain in patients with chronic stable angina and to improve symptoms in certain forms of heart failure.

GNH India supplies Isosorbide Mononitrate Accord Healthcare as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Accord Healthcare Limited

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Indications & Clinical Uses

Isosorbide Mononitrate is used in the management of cardiovascular conditions that involve myocardial oxygen demand.

  • Chronic stable angina: reduces the frequency of angina attacks by decreasing cardiac preload and afterload.
  • Heart failure with reduced ejection fraction: improves exercise tolerance and lessens dyspnea in patients with chronic heart failure.

How It Works

  • After oral absorption, isosorbide mononitrate is metabolized to nitric oxide, which activates guanylate cyclase in vascular smooth muscle. The resulting increase in cyclic GMP leads to relaxation of arterial and venous vessels, lowering both preload and afterload and thereby reducing myocardial oxygen consumption.

Side Effects

Isosorbide Mononitrate may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Headache
  • Dizziness
  • Flushing
  • Nausea
  • Hypotension
  • Palpitations

Serious or Rare Side Effects

  • Severe hypotension
  • Syncope
  • Methemoglobinemia
  • Allergic reactions such as rash or angioedema
  • Tachycardia
  • Rare myocardial infarction

Precautions & Warnings

Use of isosorbide mononitrate requires careful assessment of patient-specific factors.

  • Dose adjustment: required in patients with severe hepatic impairment.
  • Renal function: use caution in severe renal impairment.
  • Concomitant nitrates: avoid concurrent use due to additive hypotensive effect.
  • Phosphodiesterase‑5 inhibitors: contraindicated because of risk of profound hypotension.
  • Pregnancy and lactation: safety not established; use only if benefit outweighs risk.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in original container.

Avoid Interactions

Isosorbide mononitrate interacts with several drug classes that can amplify its vasodilatory action.

Major Interactions (Avoid)

  • Other organic nitrates (e.g., nitroglycerin) – may cause severe hypotension.
  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil) – risk of profound blood pressure drop.
  • Potent intravenous antihypertensives (e.g., nitroprusside) – additive hypotensive effect.

Moderate Interactions (Monitor Closely)

  • Loop diuretics – may enhance hypotensive response.
  • Other antihypertensive agents (beta‑blockers, ACE inhibitors) – monitor blood pressure.
  • Alcohol – can increase vasodilatory side effects such as dizziness and flushing.

Frequently Asked Questions

Isosorbide Mononitrate Accord Healthcare is prescribed to prevent angina attacks in patients with chronic stable angina and to alleviate symptoms in individuals with certain types of chronic heart failure.

After oral intake, the drug is converted to nitric oxide, which relaxes vascular smooth muscle by raising cyclic GMP levels. This vasodilation reduces cardiac preload and afterload, decreasing the heart’s oxygen demand.

The dosage regimen is determined by the prescribing clinician based on the patient’s clinical condition, response, and tolerance. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

Enquiries are submitted via the product page on gnhindia.com, where you specify the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Isosorbide mononitrate belongs to the organic nitrate class, offering once‑daily dosing and a longer half‑life compared with short‑acting nitrates like nitroglycerin. It provides sustained vasodilation without the need for frequent dosing, but shares the class‑related risk of tolerance and hypotension.

Store the tablets at ambient temperature, preferably below 25 °C, in the original packaging. Protect them from moisture, direct sunlight, and excessive heat to maintain product stability.

The medication is taken orally, usually as a whole tablet with a glass of water. It can be taken with or without food, but patients should follow the specific timing instructions given by their prescriber.

Serious adverse events include severe hypotension, syncope, methemoglobinemia, and rare allergic reactions such as angioedema. Patients should seek immediate medical attention if they experience sudden dizziness, fainting, or signs of an allergic response.

Individuals with known hypersensitivity to isosorbide mononitrate or any other organic nitrates, those taking phosphodiesterase‑5 inhibitors, and patients with severe hypotension should avoid this medication unless directed otherwise by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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