Product image of Isosorbide Mononitrate Flamingo Pharma Uk (Isosorbide Mononitrate) supplied by GNH India

Isosorbide Mononitrate Flamingo Pharma Uk

Active Ingredient:
Isosorbide Mononitrate
Origin:
EU

Isosorbide Mononitrate Flamingo Pharma Uk (Isosorbide Mononitrate)

Isosorbide Mononitrate, the active ingredient in Isosorbide Mononitrate Flamingo Pharma Uk, is an organic nitrate presented as an oral tablet for oral use. It is employed to prevent angina pectoris and to manage chronic stable angina in adult patients.
GNH India supplies Isosorbide Mononitrate Flamingo Pharma Uk as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Flamingo Pharma Uk Ltd

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Indications & Clinical Uses

Isosorbide Mononitrate belongs to the organic nitrate class and is used in the management of coronary artery disease.

  • Prevention of angina pectoris: reduces the frequency and severity of anginal attacks.
  • Chronic stable angina: improves exercise tolerance and decreases symptom burden.
  • Stable coronary artery disease: alleviates myocardial ischemia during daily activities.

How It Works

  • Isosorbide mononitrate is metabolized to release nitric oxide, which activates guanylate cyclase in vascular smooth muscle. The resulting increase in cyclic GMP causes relaxation of arterial and venous walls, producing vasodilation, lowering preload and afterload, and improving myocardial oxygen supply‑demand balance.

Side Effects

Common side effects are generally mild and transient.

Common Side Effects

  • Headache: often occurs at treatment initiation.
  • Dizziness or light‑headedness.
  • Flushing of the face or neck.
  • Low blood pressure (hypotension).
  • Nausea or upset stomach.
  • Palpitations or rapid heartbeat.

Serious or Rare Side Effects

  • Severe hypotension leading to syncope.
  • Acute myocardial infarction.
  • Life‑threatening allergic reaction (anaphylaxis).
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Significant liver enzyme elevation.
  • Persistent tachycardia or arrhythmia.

Precautions & Warnings

Before initiating therapy, several safety considerations should be reviewed.

  • Monitor blood pressure: check regularly, especially after dose changes.
  • Avoid concurrent use with phosphodiesterase‑5 inhibitors: risk of profound hypotension.
  • Assess renal function: dose may need adjustment in severe impairment.
  • Use caution in hepatic disease: monitor for drug accumulation.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Isosorbide mononitrate can interact with several drug classes, requiring attention to avoid adverse events.

Major Interactions (Avoid)

  • Sildenafil, tadalafil, and other PDE5 inhibitors: may cause severe hypotension.
  • Other organic nitrates or nitroglycerin: additive vasodilatory effect.
  • Potent antihypertensive agents: risk of excessive blood pressure drop.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance hypotensive response.
  • Beta‑blockers: can further reduce heart rate and blood pressure.
  • Alcohol: may increase dizziness and hypotension.

Frequently Asked Questions

Isosorbide Mononitrate is prescribed to prevent episodes of angina pectoris and to manage chronic stable angina, helping patients with coronary artery disease reduce chest pain during physical activity.

The drug releases nitric oxide after oral absorption, which activates guanylate cyclase in vascular smooth muscle. This raises cyclic GMP levels, causing vasodilation, lowering cardiac preload and afterload, and improving the balance between myocardial oxygen supply and demand.

The specific dose and dosing schedule are determined by the prescribing clinician based on the patient’s clinical condition, response, and any concomitant therapies. Patients should follow the prescriber’s instructions exactly.

Safety data for use in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

Enquiries can be submitted via the product page on gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with short‑acting nitrates, Isosorbide Mononitrate provides a longer duration of action and more stable plasma concentrations, reducing the need for multiple daily dosing. It differs from beta‑blockers and calcium‑channel blockers, which act through heart‑rate reduction or calcium antagonism rather than direct vasodilation.

Store the product at room temperature, below 25 °C, in its original packaging. Keep it away from moisture, direct sunlight, and sources of heat to maintain stability.

The medication is taken orally, usually with a glass of water. It may be taken with or without food, but patients should follow the specific instructions provided by their healthcare provider.

Serious risks include severe hypotension, syncope, myocardial infarction, and rare allergic reactions such as anaphylaxis or severe skin eruptions. Patients should seek immediate medical attention if they experience fainting, chest pain, or signs of an allergic response.

Patients with known hypersensitivity to isosorbide mononitrate or other organic nitrates, those with severe hypotension, or individuals taking phosphodiesterase‑5 inhibitors should avoid this medication unless directed otherwise by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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