Product image of Isosorbidmononitrat Al (Isosorbide Mononitrate) supplied by GNH India

Isosorbidmononitrat Al

Active Ingredient:
Isosorbide Mononitrate
Origin:
EU

Isosorbidmononitrat Al (Isosorbide Mononitrate)

Isosorbide Mononitrate, the active ingredient in Isosorbidmononitrat Al, is an organic nitrate presented as an oral tablet for oral use. It is employed to prevent angina pectoris and to manage chronic stable angina in adult patients.

GNH India supplies Isosorbidmononitrat Al as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aliud Pharma Gmbh

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Indications & Clinical Uses

Isosorbide Mononitrate belongs to the organic nitrate class and is used in the management of coronary artery disease‑related angina.

  • Prevention of angina pectoris: reduces the frequency of anginal attacks.
  • Chronic stable angina: improves exercise tolerance and reduces symptom burden.
  • Ischemic heart disease symptom control: provides sustained vasodilation to alleviate chest pain.

How It Works

  • Isosorbide Mononitrate is metabolized to release nitric oxide, which activates guanylate cyclase in vascular smooth muscle. The resulting increase in cyclic GMP leads to relaxation of arterial and venous walls, producing vasodilation that lowers preload and afterload, thereby decreasing myocardial oxygen demand and relieving angina.

Side Effects

Isosorbide Mononitrate may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects

  • Headache: mild to moderate, often transient.
  • Dizziness or light‑headedness: especially on standing.
  • Flushing: warm sensation of the skin.
  • Nausea or gastrointestinal discomfort.
  • Palpitations: awareness of heartbeat.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure.
  • Syncope: fainting episodes.
  • Methemoglobinemia: abnormal hemoglobin levels.
  • Allergic reactions: rash, pruritus, or angioedema.
  • Chest pain worsening: paradoxical increase in angina.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Concomitant nitrate use: avoid combined use to prevent severe hypotension.
  • Phosphodiesterase‑5 inhibitors: contraindicated due to risk of profound blood pressure fall.
  • Cardiovascular instability: use cautiously in patients with recent myocardial infarction or unstable angina.
  • Renal or hepatic impairment: dose may need adjustment based on clinical judgment.
  • Pregnancy and lactation: safety not established; prescribe only if benefit outweighs risk.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Isosorbide Mononitrate can interact with several drug classes, requiring clinical vigilance.

Major Interactions (Avoid)

  • Other organic nitrates or nitroglycerin: additive vasodilatory effect leading to severe hypotension.
  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil, tadalafil): risk of marked blood pressure reduction.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents (beta‑blockers, ACE inhibitors, diuretics): may enhance blood pressure‑lowering effect.
  • Antiplatelet or anticoagulant therapy: monitor for increased bleeding tendency.
  • Alcohol: can potentiate vasodilatory side effects such as dizziness.

Frequently Asked Questions

Isosorbidmononitrat Al contains isosorbide mononitrate, an oral anti‑anginal agent used to prevent episodes of angina pectoris and to manage chronic stable angina in adults with coronary artery disease.

The drug is converted in the body to nitric oxide, which activates guanylate cyclase, raising cyclic GMP levels in vascular smooth muscle. This cascade causes vasodilation, lowering cardiac preload and afterload and reducing myocardial oxygen demand.

The prescribed dose is individualized by the treating physician based on the patient’s clinical condition, response, and tolerability. Patients should follow the dosing regimen provided by their healthcare professional.

Safety in pregnancy and lactation has not been established. The drug should be used only if the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision.

Enquiries are submitted via the product page on gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with short‑acting nitrates, isosorbide mononitrate provides a longer duration of action and more stable plasma concentrations, reducing the need for frequent dosing. It differs from beta‑blockers and calcium‑channel blockers by acting primarily as a nitric‑oxide donor rather than modifying heart rate or contractility.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original container, protect it from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

The medication is taken orally, usually with a glass of water. It may be taken with or without food, but patients should follow the specific instructions given by their prescriber regarding timing and any dietary considerations.

Serious adverse events include severe hypotension, syncope, and rare cases of methemoglobinemia. Patients should seek immediate medical attention if they experience fainting, a sudden drop in blood pressure, or signs of an allergic reaction such as rash or swelling.

Individuals with known hypersensitivity to isosorbide mononitrate or any other organic nitrates should avoid the drug. It is also contraindicated in patients taking other nitrates or phosphodiesterase‑5 inhibitors due to the risk of dangerous blood‑pressure reductions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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