Product image of Isotretinoin Teva (Isotretinoin) supplied by GNH India

Isotretinoin Teva

Active Ingredient:
Isotretinoin
Origin:
EU

Isotretinoin Teva (Isotretinoin)

Isotretinoin, the active ingredient in Isotretinoin Teva, is a retinoid presented as an oral capsule for oral use. It is prescribed for severe nodular acne and for acne vulgaris that has not responded to other treatments, targeting patients who require systemic therapy.

GNH India supplies Isotretinoin Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution, ensuring timely delivery and regulatory compliance across regions.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Isotretinoin is a systemic retinoid used in the management of severe acne conditions.

  • Severe nodular acne: reduces existing lesions and prevents formation of new nodules.
  • Acne vulgaris refractory to other treatments: achieves marked reduction in inflammatory and non‑inflammatory lesions.
  • Cystic acne: leads to long‑term remission after a full treatment course.

How It Works

  • Isotretinoin binds to nuclear retinoic acid receptors, modulating gene expression that leads to decreased sebaceous gland size and sebum production, normalization of follicular keratinization, and suppression of inflammatory pathways, thereby addressing the pathogenic mechanisms of severe acne.

Side Effects

Isotretinoin may cause a range of adverse reactions, which vary in frequency and severity.

Common Side Effects

  • Dry skin and mucous membranes.
  • Cheilitis (cracked lips).
  • Xerosis (dryness) of eyes.
  • Photosensitivity.
  • Elevated serum triglycerides.
  • Transient hair thinning.

Serious or Rare Side Effects

  • Severe depression or suicidal ideation.
  • Inflammatory bowel disease.
  • Significant elevation of liver enzymes.
  • Pancreatitis.
  • Teratogenic effects leading to birth defects.
  • Severe hypervitaminosis A.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient suitability and monitor for potential risks.

  • Pregnancy contraindication: avoid use in pregnant women and ensure effective contraception.
  • Contraception requirement: two reliable methods must be used during treatment and for one month after cessation.
  • Laboratory monitoring: baseline and periodic liver function tests and lipid profiles are recommended.
  • Vitamin A supplementation: avoid concurrent use to reduce risk of toxicity.
  • Tetracycline antibiotics: avoid co‑administration as it may reduce isotretinoin efficacy.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Isotretinoin can interact with several medications, necessitating careful management.

Major Interactions (Avoid)

  • Tetracycline antibiotics: may diminish isotretinoin effectiveness.
  • Vitamin A supplements: increase risk of hypervitaminosis A.
  • Systemic corticosteroids: may exacerbate adverse skin reactions.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: isotretinoin can reduce their efficacy; additional contraceptive measures are advised.
  • Anticoagulants (e.g., warfarin): may alter INR; monitor coagulation parameters.
  • Lipid‑lowering agents: monitor lipid levels as isotretinoin can affect triglycerides.

Frequently Asked Questions

Isotretinoin Teva is prescribed for the treatment of severe nodular acne and acne vulgaris that has not responded to conventional therapies, providing a systemic approach to reduce lesions and prevent new nodule formation.

Isotretinoin binds to retinoic acid receptors, altering gene expression to shrink sebaceous glands, lower sebum output, normalize follicular keratinization, and exert anti‑inflammatory effects, thereby targeting the core mechanisms of severe acne.

The dosing regimen for Isotretinoin Teva is individualized; the prescribing clinician determines the appropriate dose based on the patient’s weight, severity of acne, and clinical response.

Isotretinoin is classified as pregnancy category X and is contraindicated in pregnancy due to a high risk of severe birth defects. It is also not recommended while breastfeeding because it may be excreted in milk.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Compared with topical agents or oral antibiotics, isotretinoin offers a systemic, disease‑modifying effect that can achieve long‑term remission in severe acne, but it requires careful monitoring for systemic side effects and strict contraception measures.

Store Isotretinoin Teva at ambient temperature, below 25 °C, in the original packaging, protected from moisture and light to maintain product stability.

Isotretinoin Teva is taken orally, usually with a meal to improve absorption, as directed by the prescribing healthcare professional.

The most serious risks include teratogenicity, severe depression or suicidal thoughts, significant liver enzyme elevation, pancreatitis, and inflammatory bowel disease; patients should be monitored closely for these events.

Isotretinoin Teva should not be used by pregnant women, individuals planning pregnancy without reliable contraception, patients with pre‑existing severe liver disease, uncontrolled hyperlipidaemia, or those taking contraindicated medications such as tetracyclines.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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