Isotretinoine Aurobindo (Isotretinoin)

Isotretinoin binds to nuclear retinoic acid receptors, altering gene transcription that reduces the size and activity of sebaceous glands, lowers sebum production, normalizes follicular keratinization, and exerts anti‑inflammatory actions, collectively addressing the key pathogenic factors of severe acne.

The exact dose is determined by the prescribing clinician based on the patient’s weight, severity of disease, and laboratory monitoring. Typical regimens start at a low daily dose and are adjusted to achieve the desired therapeutic response while minimizing adverse effects.

No. Isotretinoin is classified as pregnancy category X because it causes severe, dose‑related birth defects. It is contraindicated during pregnancy and for women who are breastfeeding. Effective contraception must be maintained throughout treatment and for at least one month after stopping the drug.

Enquiries are submitted via the product page on gnhindia.com, where you specify the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any required temperature control) and the necessary import documentation.

Compared with oral antibiotics or hormonal agents, isotretinoin offers a disease‑modifying effect by targeting sebum production and follicular keratinization, often achieving long‑term remission after a finite course. However, it carries a higher risk of systemic side effects and requires stricter monitoring, especially regarding liver function, lipids and teratogenicity.

Store the product at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep it out of reach of children and do not use if the packaging is damaged or the tablets appear discoloured.

The medication is taken orally, usually with a meal to improve absorption and reduce gastrointestinal discomfort. Swallow the tablets whole with water; do not crush, split, or chew them unless specifically instructed by a healthcare professional.

The most critical risks include severe birth defects if taken during pregnancy, psychiatric effects such as depression or suicidal thoughts, inflammatory bowel disease exacerbation, pancreatitis, marked elevations in triglycerides, and significant liver enzyme abnormalities. Immediate medical attention is required if any of these occur.

Individuals who are pregnant, planning to become pregnant, or not using reliable contraception should avoid the drug. It is also contraindicated in patients with known hypersensitivity to isotretinoin or other retinoids, those with uncontrolled hyperlipidaemia or liver disease, and anyone unable to adhere to the required monitoring schedule.