Product image of Isovorin (Calcium Levofolinate) supplied by GNH India

Isovorin

Active Ingredient:
Calcium Levofolinate
Origin:
EU

Isovorin (Calcium Levofolinate)

Calcium levofolinate, the active ingredient in Isovorin, is a folate analog presented as an oral formulation for oral use. It is employed to mitigate the toxic effects of folate antagonists and to support DNA synthesis in normal cells during chemotherapy.\n\nGNH India supplies Isovorin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pfizer S.L.

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Indications & Clinical Uses

  • Isovorin is a folate‑based antineoplastic adjuvant used to protect normal tissues during chemotherapy.\n\n- Methotrexate toxicity: reduces harmful effects of high‑dose methotrexate therapy.\n- High‑dose 5‑fluorouracil (5‑FU) treatment: provides rescue after intensive 5‑FU regimens.\n- Chemotherapy‑induced folate deficiency: supports recovery of normal cell replication during cancer treatment.

How It Works

  • Calcium levofolinate supplies reduced folate forms that bypass the metabolic block created by folate antagonists such as methotrexate. By entering the reduced folate pool, it restores tetrahydrofolate‑dependent reactions essential for purine and pyrimidine synthesis, thereby enabling DNA replication and repair in healthy cells while allowing the antimetabolite to act on malignant cells.

Side Effects

  • Adverse reactions may occur with calcium levofolinate use.\n\nCommon Side Effects:\n- Nausea or vomiting\n- Diarrhea or abdominal discomfort\n- Mild skin rash or itching\n- Transient elevation of liver enzymes\n\nSerious or Rare Side Effects:\n- Severe allergic reaction (anaphylaxis)\n- Bone marrow suppression leading to pancytopenia\n- Acute renal impairment\n- Hepatic dysfunction with jaundice

Precautions & Warnings

  • Use calcium levofolinate with appropriate clinical monitoring.\n\n- Renal function assessment: evaluate kidney status before and during therapy.\n- Hepatic monitoring: check liver enzymes regularly.\n- Folate status review: ensure patient does not have pre‑existing folate deficiency.\n- Hypersensitivity caution: discontinue if severe allergic signs appear.\n- Pregnancy and lactation: safety not established; avoid unless clearly needed.\n- Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

  • Calcium levofolinate may interact with several medications.\n\nMajor Interactions (Avoid):\n- Concurrent high‑dose methotrexate: may diminish rescue effect.\n- Other folate antagonists (e.g., pemetrexed): can increase toxicity.\n- Trimethoprim‑sulfamethoxazole: interferes with folate metabolism.\n\nModerate Interactions (Monitor Closely):\n- Non‑steroidal anti‑inflammatory drugs (NSAIDs): may affect renal clearance.\n- Proton pump inhibitors: possible alteration of absorption.\n- Antacids containing aluminum or magnesium: may reduce bioavailability.\n- Oral contraceptives: monitor for reduced efficacy.

Frequently Asked Questions

Isovorin (calcium levofolinate) is used as a folate rescue agent to reduce the toxic effects of methotrexate and to protect normal cells after high‑dose 5‑fluorouracil chemotherapy. It helps maintain DNA synthesis in healthy tissues while allowing the anticancer drug to act on tumor cells.

Calcium levofolinate provides a reduced form of folate that bypasses the metabolic block caused by folate antagonists. By replenishing tetrahydrofolate pools, it restores the enzymatic pathways needed for purine and pyrimidine synthesis, supporting DNA replication and repair in normal cells.

The dose of Isovorin is individualized and determined by the prescribing clinician based on the specific chemotherapy regimen, patient weight, renal function, and treatment goals. Healthcare professionals calculate the appropriate amount to achieve optimal rescue without compromising safety.

Safety of calcium levofolinate in pregnancy and lactation has not been established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To order Isovorin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Isovorin (calcium levofolinate) is a calcium salt of levofolinate, offering high bioavailability and rapid cellular uptake compared with some alternative folate salts. It is widely used because of its predictable pharmacokinetic profile and compatibility with standard chemotherapy protocols.

Isovorin should be stored at ambient temperature, below 25 °C, in its original container. Protect the product from moisture, excessive heat, and direct sunlight to maintain stability and potency throughout its shelf life.

Isovorin is administered orally as a tablet or capsule, taken according to the schedule prescribed by the oncologist. It is typically given shortly before or after the chemotherapy agent to provide optimal folate rescue.

Serious risks include severe allergic reactions such as anaphylaxis, bone marrow suppression leading to pancytopenia, acute renal impairment, and significant hepatic dysfunction. Patients should be monitored closely for any signs of these conditions during therapy.

Isovorin should be avoided in patients with known hypersensitivity to calcium levofolinate or any component of the formulation, and in those with severe renal or hepatic impairment where rescue may be ineffective. Clinicians must assess individual risk before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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