Product image of Ispenoral (Phenoxymethylpenicillin Potassium) supplied by GNH India

Ispenoral

Active Ingredient:
Phenoxymethylpenicillin Potassium
Origin:
EU

Ispenoral (Phenoxymethylpenicillin Potassium)

Phenoxymethylpenicillin potassium, the active ingredient in Ispenoral, is a penicillin presented as an oral tablet for oral use. It treats susceptible bacterial infections such as streptococcal pharyngitis, otitis media, and skin infections in children and adults.
GNH India supplies Ispenoral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Chephasaar Chemisch-Pharmazeutische Fabrik Gmbh

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Indications & Clinical Uses

Ispenoral (phenoxymethylpenicillin potassium) is used for infections caused by susceptible Gram‑positive bacteria.

  • Streptococcal pharyngitis: eradicates the causative streptococci and relieves throat symptoms.
  • Acute otitis media: eliminates the bacterial pathogen in the middle ear, reducing pain and inflammation.
  • Skin and soft‑tissue infections: clears Staphylococcus aureus or Streptococcus pyogenes from superficial skin lesions.

How It Works

  • Phenoxymethylpenicillin potassium inhibits bacterial cell wall synthesis by binding to penicillin‑binding proteins. This prevents cross‑linking of peptidoglycan strands, leading to weakened cell walls and eventual bacterial lysis. The drug is bactericidal against susceptible Gram‑positive organisms and works best during active bacterial growth phases.

Side Effects

Adverse reactions may occur with phenoxymethylpenicillin potassium.

Common Side Effects

  • Nausea: mild gastrointestinal upset after oral administration.
  • Diarrhea: loose stools, often self‑limiting.
  • Rash: mild skin erythema or urticaria.
  • Vaginal candidiasis: overgrowth of yeast due to altered flora.
  • Headache: transient, mild headache.
  • Abdominal pain: cramping or discomfort.

Serious or Rare Side Effects

  • Anaphylaxis: severe, potentially life‑threatening allergic reaction.
  • Stevens‑Johnson syndrome: rare severe skin and mucous membrane disorder.
  • Serum sickness‑like reaction: fever, arthralgia, rash.
  • Clostridioides difficile colitis: severe diarrhea due to bacterial overgrowth.
  • Hemolytic anemia: destruction of red blood cells in susceptible individuals.
  • Hepatic dysfunction: elevated liver enzymes in rare cases.

Precautions & Warnings

Before prescribing Ispenoral, consider the following precautions.

  • Allergy assessment: avoid use in patients with known penicillin hypersensitivity.
  • Renal impairment: adjust dosage in patients with reduced kidney function.
  • Hepatic disease: monitor liver function in patients with existing liver conditions.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk.
  • Concomitant antibiotics: avoid simultaneous use with bacteriostatic agents that may reduce efficacy.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Phenoxymethylpenicillin potassium may interact with other medicines.

Major Interactions (Avoid)

  • Bacteriostatic antibiotics (e.g., tetracyclines, chloramphenicol): may antagonize penicillin activity.
  • Probenecid: can increase penicillin plasma concentrations, raising toxicity risk.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may reduce contraceptive effectiveness; advise additional contraception.
  • Anticoagulants (e.g., warfarin): may enhance anticoagulant effect, requiring INR monitoring.
  • Methotrexate: possible increased toxicity, especially at high doses.
  • Allopurinol: may increase risk of rash.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may increase risk of renal impairment.

Frequently Asked Questions

Ispenoral contains phenoxymethylpenicillin potassium, a penicillin‑type antibiotic used to treat infections caused by susceptible Gram‑positive bacteria, such as streptococcal throat infections, acute otitis media, and mild skin and soft‑tissue infections.

Phenoxymethylpenicillin potassium binds to penicillin‑binding proteins on bacterial cell walls, inhibiting the cross‑linking of peptidoglycan strands. This weakens the cell wall, leading to bacterial lysis and death, particularly during active bacterial growth.

The dosage of Ispenoral is determined by the prescribing clinician based on the infection type, severity, patient age, weight, and renal function. Exact dosing regimens should follow the prescriber’s instructions and local guidelines.

Safety data for phenoxymethylpenicillin potassium in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under medical supervision.

To order Ispenoral, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Ispenoral (phenoxymethylpenicillin potassium) is a narrow‑spectrum oral penicillin, primarily effective against Gram‑positive organisms. Compared with broader‑spectrum penicillins like amoxicillin, it has a lower risk of disrupting normal flora but may be less suitable for infections involving resistant or Gram‑negative bacteria.

Ispenoral should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, heat, and direct sunlight to maintain its stability and potency.

Ispenoral is taken orally, usually as a tablet, with or without food as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.

The most serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, and Clostridioides difficile‑associated colitis. Patients should seek immediate medical attention if they experience symptoms like difficulty breathing, widespread rash, or persistent severe diarrhea.

Ispenoral should not be used by individuals with a known hypersensitivity to phenoxymethylpenicillin, other penicillins, or any component of the formulation. It is also contraindicated in patients with a history of severe allergic reactions to beta‑lactam antibiotics.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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