Product image of Isroen (Clopidogrel) supplied by GNH India

Isroen

Active Ingredient:
Clopidogrel
Origin:
EU

Isroen (Clopidogrel)

Clopidogrel, the active ingredient in Isroen, is an antiplatelet agent presented as an oral tablet for oral use. It helps reduce the risk of blood clots in patients with cardiovascular disease, including those who have experienced heart attacks, strokes, or have undergone coronary procedures. It is commonly prescribed to lower the incidence of myocardial infarction, ischemic stroke, and peripheral arterial disease in at‑risk populations.

GNH India supplies Isroen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across markets.

Manufacturer / TM Owner

Heremco

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Indications & Clinical Uses

Clopidogrel is used to inhibit platelet aggregation in various cardiovascular and cerebrovascular conditions.

  • Prevention of thrombotic events: Reduces the risk of clot formation in patients with established atherosclerotic disease.
  • Acute coronary syndrome: Decreases incidence of recurrent myocardial infarction and cardiovascular death in ACS patients.
  • Post‑percutaneous coronary intervention: Prevents stent thrombosis and related complications after PCI.
  • Stroke prevention: Lowers the chance of ischemic stroke in patients with prior stroke or transient ischemic attack.

How It Works

  • Clopidogrel is an irreversible antagonist of the platelet P2Y12 ADP receptor. After hepatic conversion to its active metabolite, it binds covalently to the receptor, blocking ADP-mediated activation of the GPIIb/IIIa complex and thus inhibiting platelet aggregation. This effect persists for the lifespan of the platelet, providing sustained antithrombotic activity. By preventing platelet cross‑linking, clopidogrel reduces the formation of arterial thrombi that can occlude coronary or cerebral vessels.

Side Effects

Clopidogrel may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Headache: mild to moderate pain in the head.
  • Diarrhea: loose stools, often transient.
  • Nausea: feeling of sickness or urge to vomit.
  • Bruising: easy bruising or minor bleeding from skin.

Serious or Rare Side Effects

  • Severe bleeding: gastrointestinal or intracranial hemorrhage.
  • Thrombotic thrombocytopenic purpura: rare blood disorder with low platelets.
  • Neutropenia: significant reduction in white blood cells.
  • Hypersensitivity reactions: rash, fever, or anaphylaxis.

Precautions & Warnings

When prescribing clopidogrel, clinicians should consider several precautionary measures to ensure patient safety.

  • Assess bleeding risk: evaluate history of hemorrhage or anticoagulant use.
  • Monitor liver function: check hepatic enzymes in patients with liver disease.
  • Use caution in renal impairment: adjust therapy in severe kidney dysfunction.
  • Avoid in active pathological bleeding: discontinue if uncontrolled bleeding occurs.
  • Review concomitant medications: consider potential drug interactions that may increase bleeding.
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture.

Avoid Interactions

Clopidogrel can interact with other medicines, affecting its antiplatelet efficacy or bleeding risk.

Major Interactions (Avoid)

  • Proton pump inhibitors (omeprazole, esomeprazole): may reduce activation of clopidogrel.
  • Non‑steroidal anti‑inflammatory drugs (ibuprofen, naproxen): increase bleeding risk.
  • Anticoagulants (warfarin, direct oral anticoagulants): additive anticoagulant effect.

Moderate Interactions (Monitor Closely)

  • Selective serotonin reuptake inhibitors (SSRIs): may modestly increase bleeding.
  • CYP2C19 inhibitors (fluconazole, fluoxetine): can affect clopidogrel metabolism.
  • Statins (simvastatin, atorvastatin): potential for increased plasma levels.

Frequently Asked Questions

Isroen contains clopidogrel, an antiplatelet medication prescribed to lower the risk of blood clot‑related events such as myocardial infarction, ischemic stroke, and peripheral arterial disease, particularly in patients with a history of cardiovascular or cerebrovascular disease.

Clopidogrel is converted in the liver to an active metabolite that irreversibly blocks the platelet P2Y12 ADP receptor. This inhibition prevents ADP‑mediated platelet activation and aggregation, thereby reducing the formation of arterial thrombi.

The appropriate dose of Isroen is determined by the prescribing healthcare professional based on the individual’s medical condition, response to therapy, and other clinical factors. Patients should follow the dosage instructions provided by their prescriber.

Safety data for clopidogrel in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To request Isroen, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative to clopidogrel is aspirin, another antiplatelet agent. While both reduce clot risk, clopidogrel provides more consistent platelet inhibition in patients who are resistant to aspirin and is often preferred in combination therapy after coronary stenting.

Isroen tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the medication out of reach of children and do not use if the packaging is damaged.

Isroen is taken orally, usually as a whole tablet swallowed with water. It is typically taken once daily, but the exact regimen is set by the prescribing clinician based on the patient’s condition and therapeutic goals.

The most serious risks include severe or uncontrolled bleeding, such as gastrointestinal or intracranial hemorrhage, and rare blood disorders like thrombotic thrombocytopenic purpura. Patients should seek immediate medical attention if they notice unusual bruising, blood in stool or urine, or sudden severe headaches.

Isroen should be avoided in individuals with active pathological bleeding, a known hypersensitivity to clopidogrel or any component of the formulation, and in patients with severe liver disease. A thorough medical assessment is required before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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