Product image of Istin (Amlodipine) supplied by GNH India

Istin

Active Ingredient:
Amlodipine
Origin:
EU

Istin (Amlodipine)

Amlodipine, the active ingredient in Istin, is a calcium channel blocker presented as an oral tablet for oral use. It is employed to manage high blood pressure and certain types of chest pain in adult patients.

GNH India supplies Istin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Upjohn Eesv

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Indications & Clinical Uses

Amlodipine is used to treat conditions related to cardiovascular pressure and blood flow.

  • Hypertension: lowers elevated blood pressure and reduces the risk of cardiovascular complications.
  • Chronic stable angina: improves exercise tolerance by decreasing myocardial oxygen demand.
  • Coronary artery disease: helps prevent angina episodes and supports overall cardiac perfusion.

How It Works

  • Amlodipine blocks L‑type calcium channels in vascular smooth muscle and cardiac myocytes, reducing calcium influx. This inhibition leads to relaxation of arterial smooth muscle, vasodilation, and a decrease in peripheral vascular resistance, thereby lowering blood pressure and reducing cardiac workload.

Side Effects

Amlodipine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Peripheral edema: swelling of ankles or lower legs.
  • Flushing: transient warmth and redness of the skin.
  • Dizziness: especially upon standing quickly.
  • Fatigue: general sense of tiredness.
  • Nausea: occasional upset stomach.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Myocardial infarction: rare occurrence of heart attack.
  • Hepatic dysfunction: abnormal liver enzyme elevations.
  • Allergic reactions: rash, itching, or swelling of the face and throat.

Precautions & Warnings

Before initiating therapy with amlodipine, consider the following safety measures.

  • Blood pressure monitoring: check baseline and periodic readings to assess response.
  • Cardiac function assessment: evaluate for existing heart failure or recent myocardial infarction.
  • Concomitant medications: review for drugs that may potentiate hypotensive effects.
  • Pregnancy and lactation: discuss potential risks with a healthcare professional.
  • Renal or hepatic impairment: adjust therapy based on organ function.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Amlodipine can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Simultaneous use with strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole): may increase amlodipine plasma levels and risk of hypotension.
  • Co‑administration with other potent antihypertensives (e.g., beta‑blockers, ACE inhibitors): can cause excessive blood pressure reduction.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may lower amlodipine concentrations, reducing effectiveness.
  • Grapefruit juice: can modestly raise drug levels, requiring blood pressure monitoring.
  • Diuretics: may enhance orthostatic hypotension, especially in the elderly.

Frequently Asked Questions

Istin contains amlodipine, which is prescribed to lower high blood pressure, relieve chronic stable angina, and manage coronary artery disease. By relaxing blood vessels, it improves blood flow and reduces the workload on the heart, helping to prevent complications associated with these cardiovascular conditions.

Amlodipine blocks L‑type calcium channels in the smooth muscle of arteries and the heart. This action prevents calcium from entering the cells, leading to relaxation of the vascular smooth muscle, vasodilation, and a reduction in peripheral resistance. The resulting effect is lower blood pressure and decreased cardiac oxygen demand.

The appropriate dose of Istin is determined by a qualified prescriber based on the individual’s medical condition, response to therapy, and other medications. Healthcare professionals tailor the dosage to achieve optimal blood pressure control while minimizing potential side effects.

The safety of amlodipine during pregnancy or lactation has not been definitively established. It should only be used if the potential benefits outweigh the risks, and this decision must be made by a healthcare provider after careful evaluation of the mother’s condition.

To place an order, submit an enquiry on the Istin product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Istin (amlodipine) belongs to the calcium channel blocker class, which differs from ACE inhibitors, beta‑blockers, or diuretics in its mechanism of vasodilation. It is often chosen for patients who need once‑daily dosing, have peripheral edema concerns, or require a medication that does not affect heart rate significantly.

Istin should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture, heat, and direct sunlight to maintain potency throughout the shelf life.

Istin is taken orally, usually once daily, with or without food. Swallow the tablet whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare professional and not alter the timing without medical advice.

Serious adverse events, though rare, can include severe hypotension, myocardial infarction, and significant liver enzyme elevations. Patients should seek immediate medical attention if they experience symptoms such as fainting, chest pain, or signs of an allergic reaction like swelling of the face or throat.

Istin is contraindicated in individuals with known hypersensitivity to amlodipine or any other calcium channel blocker. Patients with severe aortic stenosis, uncontrolled heart failure, or those taking certain strong CYP3A4 inhibitors should avoid it unless a physician determines it is safe.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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