Product image of Italprid (Tiapride Hydrochloride) supplied by GNH India

Italprid

Active Ingredient:
Tiapride Hydrochloride
Origin:
EU

Italprid (Tiapride Hydrochloride)

Tiapride, the active ingredient in Italprid, is a benzamide antipsychotic presented as an oral dosage form for oral use. It is employed to manage agitation associated with schizophrenia, as well as motor disturbances in Huntington’s disease and chorea. It is indicated for patients who require symptomatic control of psychomotor agitation and for those with neurodegenerative movement disorders.

GNH India supplies Italprid as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide through regulated distribution channels.

Manufacturer / TM Owner

Teofarma S.R.L.

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Indications & Clinical Uses

Tiapride is used in the management of disorders involving dopaminergic hyperactivity, particularly in psychiatric and movement‑disorder settings.

  • Schizophrenia (agitation): reduces psychomotor agitation and improves behavioral stability in patients experiencing acute agitation.
  • Huntington's disease: alleviates choreiform movements and associated motor symptoms.
  • Chorea (non‑Huntington): diminishes involuntary movements and improves motor control.

How It Works

  • Tiapride acts as a selective antagonist at dopamine D2 and D3 receptors, preferentially blocking postsynaptic dopaminergic transmission in limbic and basal ganglia pathways. This antagonism reduces excessive dopaminergic activity that underlies agitation and abnormal involuntary movements, thereby providing symptomatic control in psychiatric and neurodegenerative conditions.

Side Effects

Adverse reactions may occur with Tiapride therapy and should be monitored.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Nausea: mild to moderate stomach upset.
  • Dry mouth: reduced salivation leading to discomfort.
  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Constipation: infrequent bowel movements.
  • Headache: mild to moderate head pain.

Serious or Rare Side Effects

  • Extrapyramidal symptoms: muscle rigidity, tremor, or abnormal gait.
  • Neuroleptic malignant syndrome: rare but life‑threatening hyperthermia and muscle breakdown.
  • Severe hypotension: marked drop in blood pressure causing faintness.
  • Cardiac arrhythmia: irregular heart rhythm, especially in susceptible individuals.
  • Suicidal ideation: emergence of thoughts of self‑harm.
  • Severe depression: marked mood worsening requiring urgent care.

Precautions & Warnings

Before initiating Tiapride therapy, clinicians should consider several safety aspects.

  • Monitor for extrapyramidal symptoms: assess motor function regularly.
  • Assess cardiovascular status: watch for hypotension or arrhythmias.
  • Use caution in hepatic impairment: dose adjustment may be required.
  • Avoid abrupt discontinuation: taper gradually to reduce withdrawal effects.
  • Pregnancy and lactation: safety not established, use only if benefits outweigh risks.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Tiapride may interact with other medicines; awareness of potential interactions helps maintain safety.

Major Interactions (Avoid)

  • Concomitant dopamine antagonists: increase risk of extrapyramidal symptoms.
  • MAO inhibitors: may potentiate hypotensive effects.
  • QT‑prolonging agents: raise risk of cardiac arrhythmia.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors: can raise Tiapride plasma concentrations.
  • Alcohol: may enhance sedation and dizziness.
  • Antihypertensive drugs: additive blood‑pressure‑lowering effect.

Frequently Asked Questions

Italprid contains Tiapride, which is prescribed to control acute agitation in schizophrenia and to reduce involuntary movements in Huntington’s disease and other forms of chorea. It helps improve behavioral stability and motor function in these conditions.

Tiapride selectively blocks dopamine D2 and D3 receptors in the brain, especially within limbic and basal‑ganglia circuits. By reducing excessive dopaminergic signaling, it lessens agitation and abnormal motor activity associated with certain psychiatric and neurodegenerative disorders.

The dosage of Italprid is individualized and set by the prescribing clinician based on the patient’s condition, age, renal function and response. Specific dosing regimens are not provided here and should follow the prescriber’s instructions.

Safety data for Tiapride in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To request Italprid, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with typical antipsychotics such as haloperidol, Tiapride has a more selective D2/D3 antagonism and a lower propensity for certain side effects like prolactin elevation. However, like other dopamine blockers, it can still cause extrapyramidal symptoms, so choice of therapy depends on the clinical profile and tolerability needs.

Store Italprid at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture, heat and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Italprid is taken orally. The tablets should be swallowed whole with a glass of water, preferably with or without food as directed by the prescriber. Do not crush, chew, or split the tablets unless specifically advised.

Serious risks include extrapyramidal symptoms such as severe rigidity or tremor, neuroleptic malignant syndrome—a rare but life‑threatening reaction, marked hypotension, cardiac arrhythmias, and the emergence of suicidal thoughts or severe depression. Immediate medical attention is required if any of these occur.

Italprid should be avoided in individuals with known hypersensitivity to Tiapride or any component of the formulation, in patients with severe hepatic impairment, and in those with a history of neuroleptic malignant syndrome. Caution is also advised for patients with uncontrolled cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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