Product image of Itami (Diclofenac Sodium) supplied by GNH India

Itami

Active Ingredient:
Diclofenac Sodium
Origin:
EU

Itami (Diclofenac Sodium)

Diclofenac sodium, the active ingredient in Itami, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a topical formulation for cutaneous use. It is indicated for relief of mild to moderate musculoskeletal pain and for reduction of inflammation in conditions such as osteoarthritis, rheumatoid arthritis, sprains and strains.
GNH India supplies Itami as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Fidia Farmaceutici S.P.A

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Indications & Clinical Uses

Diclofenac sodium works locally on inflamed tissues and is used for several musculoskeletal conditions.

  • Musculoskeletal pain: provides topical analgesia for mild to moderate pain.
  • Osteoarthritis: reduces joint inflammation and improves mobility.
  • Rheumatoid arthritis: alleviates localized joint swelling and discomfort.
  • Sprains and strains: diminishes swelling and speeds functional recovery.

How It Works

  • Diclofenac sodium exerts its effect by reversibly inhibiting cyclooxygenase‑1 and cyclooxygenase‑2 (COX‑1 and COX‑2) enzymes in peripheral tissues. This inhibition lowers prostaglandin synthesis, which in turn reduces inflammation, pain signalling, and edema at the site of application without significant systemic exposure.

Side Effects

Topical diclofenac may cause local and systemic reactions, most of which are mild and reversible.

Common Side Effects

  • Skin irritation: redness, itching or burning at the application site.
  • Dryness: localized dryness or peeling of the skin.
  • Pruritus: mild itching without rash.
  • Erythema: transient redness of the treated area.

Serious or Rare Side Effects

  • Allergic reaction: hives, swelling, or difficulty breathing.
  • Severe dermatitis: blistering or extensive rash.
  • Systemic NSAID effects: rare gastrointestinal upset or headache.
  • Photosensitivity: increased skin sensitivity to sunlight.
  • Stevens‑Johnson syndrome: extremely rare severe skin reaction.

Precautions & Warnings

When using a topical NSAID, certain safety measures should be observed.

  • Avoid application on broken or infected skin: may increase systemic absorption.
  • Do not use on large surface areas: limits systemic exposure.
  • Keep away from eyes and mucous membranes: can cause irritation.
  • Discontinue if severe skin reaction occurs: seek medical advice.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Topical diclofenac can interact with systemic medications that affect bleeding or renal function.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal and renal toxicity.
  • Lithium: potential increase in lithium levels.
  • Methotrexate: enhanced methotrexate toxicity.
  • Systemic corticosteroids: heightened risk of ulceration.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible renal function changes.
  • Diuretics: monitor renal parameters.
  • SSRIs or SNRIs: modest increase in bleeding tendency.
  • Beta‑blockers: watch for blood pressure alterations.
  • Alcohol: may exacerbate gastrointestinal irritation.

Frequently Asked Questions

Itami, containing diclofenac sodium, is applied to the skin to relieve mild to moderate musculoskeletal pain and to reduce inflammation associated with osteoarthritis, rheumatoid arthritis, sprains and strains. The topical route targets the affected area directly, providing localized analgesic and anti‑inflammatory effects.

Diclofenac sodium inhibits the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes in peripheral tissues, which decreases the production of prostaglandins. Lower prostaglandin levels reduce inflammation, pain signalling, and swelling at the site where the gel is applied.

The specific dose and frequency of Itami are determined by the prescribing healthcare professional based on the patient’s condition, age, and treatment response. Patients should follow the prescriber’s instructions and the product label for proper application.

Safety data for topical diclofenac during pregnancy and lactation are limited. Healthcare providers generally advise caution and may recommend alternative therapies unless the potential benefit outweighs any possible risk. Patients should discuss their individual situation with a qualified professional.

To request Itami, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Itami delivers diclofenac sodium directly to the skin, offering localized relief with lower systemic exposure compared with oral NSAIDs. This can reduce the risk of gastrointestinal and cardiovascular side effects common to systemic NSAIDs, while still providing effective analgesia for targeted musculoskeletal conditions.

Itami should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and avoid freezing to maintain product stability.

Apply a thin layer of the gel to the affected skin area, gently massaging until absorbed. Follow the prescriber’s recommended frequency, typically not exceeding the amount specified on the label. Wash hands after application unless the treated area is the hands themselves.

Serious risks, though rare, include severe allergic reactions such as hives, swelling, or difficulty breathing, and rare systemic NSAID effects like gastrointestinal bleeding or renal impairment. If any signs of a serious reaction appear, discontinue use and seek immediate medical attention.

Individuals with known hypersensitivity to diclofenac, other NSAIDs, or any component of the formulation should avoid Itami. It should also not be used on open wounds, infected skin, or extensive body surface areas without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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