Itami (Diclofenac Sodium)

Diclofenac sodium works by reversibly inhibiting the cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This inhibition blocks the conversion of arachidonic acid into prostaglandins, which are mediators of inflammation, pain and swelling. By lowering prostaglandin levels at the site of application, diclofenac reduces the inflammatory response and pain perception.

The appropriate dose of Itami is determined by the prescribing healthcare professional based on the patient’s condition, age, and the size of the area to be treated. The prescriber will specify the amount to apply, the frequency of application, and the maximum duration of therapy.

Safety data for topical diclofenac during pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternative treatments with their healthcare provider.

To order Itami, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements) and assist with import documentation.

Itami delivers diclofenac directly to the skin, which can provide effective pain relief with lower systemic exposure compared with oral NSAIDs. This topical route may reduce the risk of gastrointestinal side effects common with oral agents. Compared with other topical NSAIDs, diclofenac has a well‑established efficacy profile for musculoskeletal pain, though individual response can vary.

Store Itami at room temperature, preferably below 25 °C (77 °F). Keep the product in its original packaging, protect it from moisture, direct sunlight and excessive heat. Do not freeze the preparation. Ensure the container is tightly closed when not in use to maintain stability.

Itami is applied to clean, dry skin over the painful or inflamed area. The prescriber will indicate the amount (e.g., a pea‑size amount) and frequency, typically 2–4 times daily. Gently rub the gel or cream until it disappears, and wash hands after application unless the hands are the treatment site.

Serious risks, although rare, include severe allergic reactions such as swelling, hives, or difficulty breathing, and rare skin conditions like Stevens‑Johnson syndrome. Systemic NSAID toxicity—such as gastrointestinal ulceration, renal impairment, or cardiovascular events—can occur, especially with extensive or inappropriate use. Patients should seek immediate medical attention if they notice any of these signs.

Itami should not be used by individuals with known hypersensitivity to diclofenac, other NSAIDs, or any component of the formulation. It is also contraindicated on broken, infected or inflamed skin, and should be avoided in patients with a history of severe cardiovascular disease, uncontrolled hypertension, or active peptic ulcer disease unless directed by a physician.