Product image of Itami Unidie (Diclofenac Sodium) supplied by GNH India

Itami Unidie

Active Ingredient:
Diclofenac Sodium
Origin:
EU

Itami Unidie (Diclofenac Sodium)

Diclofenac Sodium, the active ingredient in Itami Unidie, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as a topical formulation for topical use. It provides pain relief and reduces inflammation in musculoskeletal conditions for adult patients. GNH India supplies Itami Unidie as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Fidia Farmaceutici S.P.A

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Indications & Clinical Uses

Diclofenac Sodium is applied topically to manage inflammatory pain in the musculoskeletal system.

  • Osteoarthritis: reduces joint pain and improves function in affected joints.
  • Rheumatoid arthritis: alleviates localized joint inflammation and discomfort.
  • Sprains and strains: diminishes pain and swelling in soft‑tissue injuries.
  • Post‑operative pain: provides localized analgesia after minor surgical procedures.

How It Works

  • Diclofenac Sodium reversibly inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes at the site of application, decreasing the synthesis of prostaglandins that mediate inflammation, pain, and fever. By limiting prostaglandin production in peripheral tissues, the drug reduces local inflammatory responses and nociceptive signaling, resulting in analgesic and anti‑inflammatory effects.

Side Effects

Topical diclofenac is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Skin irritation at the application site: redness, itching, or burning sensation.
  • Dryness or peeling of the skin.
  • Mild rash or contact dermatitis.
  • Localized swelling.
  • Sensation of warmth or tingling.

Serious or Rare Side Effects

  • Severe allergic reaction: hives, swelling of face or throat, difficulty breathing.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Systemic NSAID effects: gastrointestinal ulceration or bleeding.
  • Liver enzyme elevation.
  • Kidney function impairment.

Precautions & Warnings

When using topical diclofenac, consider the following precautions.

  • Contraindications: avoid use in patients with known hypersensitivity to diclofenac or other NSAIDs.
  • Pregnancy: consult a healthcare professional before use; safety data are limited.
  • Breastfeeding: discuss potential risks with a physician.
  • Skin integrity: do not apply to broken, infected, or irritated skin.
  • Drug interactions: review concomitant medications for possible NSAID interactions.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Diclofenac sodium may interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.
  • Lithium: elevated lithium serum levels.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in renal function.
  • Diuretics: potential for decreased renal perfusion.
  • Methotrexate: risk of increased methotrexate toxicity.

Frequently Asked Questions

Itami Unidie is a topical diclofenac product indicated for the relief of pain and reduction of inflammation associated with osteoarthritis, rheumatoid arthritis, sprains, strains, and minor postoperative discomfort. It is applied directly to the affected skin area to target localized musculoskeletal pain.

Diclofenac sodium inhibits cyclooxygenase enzymes (COX‑1 and COX‑2) in the skin and underlying tissues, which reduces the production of prostaglandins that cause inflammation and pain. This localized inhibition leads to decreased swelling and analgesic effects at the site of application.

The specific dose and frequency of Itami Unidie are determined by the prescribing healthcare professional based on the patient’s condition, severity of symptoms, and treatment guidelines. Patients should follow the prescriber’s instructions and the product label.

Safety data for topical diclofenac during pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks with their healthcare provider before using Itami Unidie.

To order Itami Unidie, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Itami Unidie delivers diclofenac directly to the skin, offering targeted pain relief with lower systemic exposure compared with oral NSAIDs. This can reduce the risk of gastrointestinal side effects while providing effective anti‑inflammatory action for localized conditions.

Store Itami Unidie at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, and avoid direct sunlight to maintain stability and efficacy.

Itami Unidie is applied topically to clean, dry skin over the affected area. The prescribed amount is spread in a thin layer and gently massaged until fully absorbed. Hands should be washed after application, and the treated skin should not be covered with occlusive dressings unless directed by a clinician.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, and systemic NSAID effects like gastrointestinal bleeding, liver enzyme elevation, or kidney impairment. Patients should seek immediate medical attention if they experience symptoms such as rash, swelling, difficulty breathing, or unexplained abdominal pain.

Individuals with known hypersensitivity to diclofenac, other NSAIDs, or any component of the formulation should avoid Itami Unidie. It is also contraindicated on broken, infected, or irritated skin, and should be used with caution in patients with a history of cardiovascular, renal, or hepatic disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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