Product image of Itamidol (Diclofenac) supplied by GNH India

Itamidol

Active Ingredient:
Diclofenac
Origin:
EU

Itamidol (Diclofenac)

Diclofenac, the active ingredient in Itamidol, is a nonsteroidal anti-inflammatory drug presented as a topical formulation for cutaneous use. It provides relief of mild to moderate pain and reduces inflammation in musculoskeletal conditions and localized swelling. The product is formulated for external application to the skin, allowing targeted action at the site of pain without systemic exposure.

GNH India supplies Itamidol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality and regulatory compliance.

Manufacturer / TM Owner

Fidia Farmaceutici S.P.A

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Indications & Clinical Uses

Diclofenac acts locally on inflamed tissues to alleviate pain and swelling in several musculoskeletal and dermatologic conditions.

  • Mild to moderate musculoskeletal pain: reduces pain intensity and improves function.
  • Localized joint inflammation (e.g., osteoarthritis of the knee): diminishes swelling and stiffness.
  • Superficial soft‑tissue injuries (sprains, strains): provides topical analgesia and anti‑inflammatory effect.
  • Post‑operative incision discomfort: eases localized pain at the surgical site.
  • Dermatologic inflammatory lesions (e.g., erythema, edema): helps reduce redness and swelling.

How It Works

  • Diclofenac inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes in peripheral tissues, decreasing the synthesis of prostaglandins that mediate inflammation, pain, and fever. By limiting prostaglandin production at the site of application, the drug reduces vascular permeability, edema, and nociceptor sensitisation, resulting in localized analgesic and anti‑inflammatory effects.

Side Effects

Topical diclofenac may cause local and systemic adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Skin irritation at the application site.
  • Burning or stinging sensation.
  • Pruritus.
  • Dryness of the treated area.

Serious or Rare Side Effects

  • Allergic contact dermatitis.
  • Stevens‑Johnson syndrome or other severe cutaneous reactions.
  • Systemic NSAID effects such as gastrointestinal ulceration, hepatotoxicity, or renal impairment.

Precautions & Warnings

When using Itamidol, consider the following safety measures.

  • Assess skin integrity: avoid application on broken or infected skin.
  • Limit use to the prescribed area: do not cover with occlusive dressings unless directed.
  • Monitor for systemic NSAID effects: especially in patients with cardiovascular or renal disease.
  • Avoid concurrent use with other topical NSAIDs: to reduce cumulative exposure.
  • Store below 25°C: keep in original packaging, protect from moisture and light.

Avoid Interactions

Diclofenac can interact with other medicines; some combinations should be avoided while others require monitoring.

Major Interactions (Avoid)

  • Concurrent systemic NSAIDs (e.g., ibuprofen, naproxen): increased risk of gastrointestinal bleeding.
  • Anticoagulants (warfarin, direct oral anticoagulants): heightened bleeding risk.
  • Lithium therapy: diclofenac may raise lithium plasma concentrations.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: potential impact on renal function.
  • Diuretics: may reduce renal perfusion when combined.
  • Methotrexate: diclofenac can decrease clearance, increasing toxicity risk.

Frequently Asked Questions

Itamidol is a topical formulation of diclofenac that is used to relieve mild to moderate pain and to reduce inflammation in musculoskeletal conditions, localized joint swelling, soft‑tissue injuries, post‑operative incision discomfort, and superficial dermatologic inflammatory lesions.

Diclofenac blocks the cyclooxygenase (COX‑1 and COX‑2) enzymes, which are essential for prostaglandin synthesis. By lowering prostaglandin levels in the treated area, it diminishes inflammation, edema, and the activation of pain receptors, providing localized analgesic and anti‑inflammatory effects.

The appropriate amount of Itamidol is determined by the prescribing healthcare professional based on the specific condition, severity, and patient characteristics. Patients should follow the prescriber’s instructions and the product label for application frequency and quantity.

Safety data for topical diclofenac in pregnancy and lactation are limited. It is generally advised to avoid use unless the potential benefit outweighs the possible risk, and the decision should be made by a qualified healthcare provider.

To place an order, submit an enquiry on the Itamidol product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Itamidol delivers diclofenac directly to the skin, offering targeted pain relief with lower systemic exposure compared with oral NSAIDs. This can reduce the risk of gastrointestinal and cardiovascular side effects, although local skin reactions may be more common than with systemic formulations.

Store Itamidol below 25 °C in its original container, protecting it from moisture, heat and direct sunlight. Keep the product out of reach of children and avoid using it after the expiration date printed on the packaging.

Itamidol is applied topically to clean, dry skin. A thin layer is spread over the affected area and gently massaged until absorbed, usually 2–4 times daily or as directed by the prescriber. Occlusive dressings should not be used unless specifically advised.

Serious risks include severe allergic reactions such as Stevens‑Johnson syndrome, systemic NSAID effects like gastrointestinal ulceration, liver toxicity, and renal impairment. Patients should discontinue use and seek medical attention if they experience signs of a severe skin reaction or systemic symptoms.

Itamidol should be avoided in individuals with known hypersensitivity to diclofenac or other NSAIDs, in patients with active skin infections or open wounds at the intended site, and in those with a history of severe cutaneous adverse reactions. Caution is also advised for patients with significant cardiovascular, renal or hepatic disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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