Itamione (Diclofenac Sodium)

Diclofenac sodium blocks cyclooxygenase enzymes (COX‑1 and COX‑2) in peripheral tissues, reducing the formation of prostaglandins that drive inflammation, pain and swelling. By limiting prostaglandin synthesis locally, the drug diminishes the inflammatory response at the site of application.

The exact dose, frequency and duration of application are determined by the prescribing healthcare professional based on the severity of the condition, the size of the treatment area and individual patient factors. The prescriber will provide specific instructions on how much gel or cream to apply and how often.

Safety of topical diclofenac in pregnancy and lactation has not been fully established. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and always after discussion with a qualified healthcare provider.

To request Itamione, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will ask for trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Itamione delivers diclofenac directly to the skin, providing high local concentrations while keeping systemic exposure low compared with oral NSAIDs. This can result in fewer gastrointestinal side effects, but topical use may cause local skin reactions. The choice between topical and oral NSAIDs depends on the clinical situation and patient tolerance.

Store Itamione at room temperature, ideally below 25 °C. Keep the product in its original container, protect it from moisture, direct sunlight and extreme temperatures. Do not freeze the preparation, and ensure the cap is tightly closed when not in use.

Itamione is applied externally to the affected skin area. The prescribed amount is spread thinly and gently massaged into clean, dry skin, usually 2–4 times daily, unless otherwise directed by the prescriber. Hands should be washed before and after application to avoid accidental contact with eyes or mucous membranes.

Although rare, serious adverse reactions can include severe allergic skin reactions such as Stevens‑Johnson syndrome, systemic hypersensitivity (including anaphylaxis), and liver toxicity. Patients should seek immediate medical attention if they notice widespread rash, blistering, jaundice, or signs of an allergic reaction.

Itamione should be avoided in individuals with known hypersensitivity to diclofenac, other NSAIDs, or any excipients in the formulation. It is also contraindicated on broken, infected or severely damaged skin, and should be used with caution in patients taking systemic anticoagulants, lithium, or methotrexate.