Product image of Itoco (Dorzolamide) supplied by GNH India

Itoco

Active Ingredient:
Dorzolamide
Origin:
EU

Itoco (Dorzolamide)

Dorzolamide, the active ingredient in Itoco, is a carbonic anhydrase inhibitor presented as a topical ophthalmic solution for ocular (topical) use. It lowers intra‑ocular pressure and is employed in the management of primary open‑angle glaucoma and ocular hypertension in adult patients, helping to prevent optic nerve damage.

GNH India supplies Itoco as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing EU‑standard quality and reliable global distribution.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

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Indications & Clinical Uses

  • Dorzolamide is used in glaucoma therapy to reduce intra‑ocular pressure by decreasing aqueous humor production.
  • Primary open‑angle glaucoma: lowers intra‑ocular pressure to protect the optic nerve.
  • Ocular hypertension: reduces eye pressure to prevent progression to glaucoma.
  • Secondary open‑angle glaucoma: assists in controlling pressure when other causes are present.

How It Works

  • Dorzolamide inhibits the enzyme carbonic anhydrase in the ciliary body of the eye. This inhibition reduces the formation of bicarbonate ions, decreasing aqueous humor secretion and consequently lowering intra‑ocular pressure, which helps to prevent optic nerve damage associated with glaucoma.

Side Effects

Common Side Effects

  • Transient ocular burning or stinging after instillation.
  • Blurred vision that resolves shortly after use.
  • Altered taste sensation when the solution drains into the throat.
  • Mild eye discomfort or redness.
  • Headache.

Serious or Rare Side Effects

  • Severe allergic reaction including swelling of the eyelids or face.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Corneal edema or persistent corneal opacity.
  • Significant intra‑ocular inflammation.
  • Sudden loss of vision.

Precautions & Warnings

  • Before using Itoco, consider the following precautions.
  • Pregnancy: safety not established; use only if benefit outweighs risk.
  • Breastfeeding: unknown safety; evaluate potential risks.
  • Contact lens wearers: may cause discomfort; remove lenses before instillation.
  • Concurrent ocular hypotensives: monitor intra‑ocular pressure closely.
  • Sulfonamide allergy: avoid if patient has known hypersensitivity.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Dorzolamide may interact with other medications; monitor as indicated.

Major Interactions (Avoid)

  • Systemic carbonic anhydrase inhibitors (e.g., acetazolamide): additive IOP‑lowering may cause hypotony.
  • Topical beta‑blockers: increased risk of excessive ocular hypotension.
  • Topical prostaglandin analogues: may reduce overall efficacy.

Moderate Interactions (Monitor Closely)

  • Oral sulfonamide antibiotics: potential cross‑reaction in sulfonamide‑sensitive patients.
  • Topical corticosteroids: may counteract IOP‑lowering effect and require monitoring.

Frequently Asked Questions

Itoco contains dorzolamide, which is prescribed to lower intra‑ocular pressure in adults with primary open‑angle glaucoma or ocular hypertension, helping to protect the optic nerve and preserve vision.

Dorzolamide blocks carbonic anhydrase in the eye’s ciliary body, reducing the production of aqueous humor. This decrease in fluid lowers intra‑ocular pressure, a key factor in managing glaucoma and ocular hypertension.

The dosing regimen for Itoco is determined by the prescribing clinician based on the patient’s condition, response, and tolerance. The prescriber will specify the number of drops and frequency appropriate for each individual.

Safety data for dorzolamide in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To request Itoco, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Itoco (dorzolamide) belongs to the carbonic anhydrase inhibitor class, which lowers eye pressure by reducing aqueous humor production. Other classes, such as beta‑blockers or prostaglandin analogues, act via different mechanisms. Choice of therapy depends on efficacy, tolerability, patient comorbidities and physician preference.

Itoco should be stored at room temperature, away from direct sunlight and moisture. Keep the bottle tightly closed in its original packaging until use to maintain stability and potency.

Itoco is applied as an eye drop. The patient should wash hands, tilt the head back, pull down the lower eyelid to create a pocket, and place the prescribed number of drops into the eye. Close the eye gently and avoid blinking excessively for a few seconds.

Serious risks include severe allergic reactions, Stevens‑Johnson syndrome, corneal edema, and sudden loss of vision. Patients should seek immediate medical attention if they experience swelling, rash, vision changes, or persistent eye irritation.

Itoco is contraindicated in patients with known hypersensitivity to dorzolamide, sulfonamides, or any component of the formulation. It should also be used with caution in individuals with severe renal impairment or those taking systemic carbonic anhydrase inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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