Product image of Itoco (Dorzolamide) supplied by GNH India

Itoco

Active Ingredient:
Dorzolamide
Origin:
EU

Itoco (Dorzolamide)

Dorzolamide, the active ingredient in Itoco, is a carbonic anhydrase inhibitor presented as a topical ophthalmic solution for ocular use. It lowers intra‑ocular pressure in patients with open‑angle glaucoma or ocular hypertension.

GNH India supplies Itoco as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

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Indications & Clinical Uses

  • Dorzolamide acts on the ocular fluid‑production pathway to reduce intra‑ocular pressure in glaucoma‑related conditions.
  • Open‑angle glaucoma: reduces intra‑ocular pressure to help prevent optic nerve damage.
  • Ocular hypertension: lowers eye pressure to reduce the risk of developing glaucoma.

How It Works

  • Dorzolamide inhibits carbonic anhydrase enzymes in the ciliary body epithelium, decreasing the formation of aqueous humor. This reduction in fluid production leads to lower intra‑ocular pressure, helping to control glaucoma and ocular hypertension.

Side Effects

Adverse reactions are generally related to local ocular irritation or systemic hypersensitivity.

Common Side Effects

  • Burning or stinging sensation in the eye
  • Blurred vision after instillation
  • Unpleasant taste sensation
  • Conjunctival hyperemia (redness)
  • Foreign body sensation
  • Mild eye discomfort

Serious or Rare Side Effects

  • Severe allergic reactions such as Stevens‑Johnson syndrome
  • Corneal edema or ulceration
  • Granulomatous inflammation of the eyelid
  • Persistent ocular pain
  • Vision loss
  • Systemic sulfonamide hypersensitivity

Precautions & Warnings

  • Before using Itoco, consider the following safety measures.
  • Monitor intra‑ocular pressure regularly: ensure therapeutic effectiveness.
  • Assess sulfonamide allergy history: avoid if hypersensitivity is known.
  • Avoid use in severe corneal disease: may exacerbate condition.
  • Do not combine with other carbonic anhydrase inhibitor eye drops without medical supervision: risk of excessive pressure reduction.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Dorzolamide may interact with other ocular or systemic medications.

Major Interactions (Avoid)

  • Concurrent use with other carbonic anhydrase inhibitor eye drops (e.g., brinzolamide) may cause additive pressure‑lowering effects.
  • Systemic sulfonamides may increase risk of hypersensitivity reactions.
  • Combination with topical ocular anesthetics may heighten corneal toxicity.

Moderate Interactions (Monitor Closely)

  • Beta‑blocker eye drops may produce additive intra‑ocular pressure reduction.
  • Systemic carbonic anhydrase inhibitors (e.g., acetazolamide) may increase systemic side effects.
  • Use with prostaglandin analogues may require IOP monitoring for synergistic effect.

Frequently Asked Questions

Itoco contains dorzolamide, which is prescribed to lower intra‑ocular pressure in patients with open‑angle glaucoma or ocular hypertension. By reducing eye pressure, it helps protect the optic nerve and prevent vision loss associated with these conditions.

Dorzolamide inhibits carbonic anhydrase enzymes in the ciliary body of the eye. This inhibition reduces the production of aqueous humor, the fluid that maintains eye pressure, thereby lowering intra‑ocular pressure and managing glaucoma or ocular hypertension.

The dosing regimen for Itoco is determined by the prescribing ophthalmologist based on the patient’s condition and response. Typically, dorzolamide eye drops are administered one or two times daily, but the exact schedule should follow the prescriber’s instructions.

Safety data for dorzolamide in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Itoco (dorzolamide) belongs to the carbonic anhydrase inhibitor class, which lowers eye pressure by reducing aqueous humor production. Alternatives include beta‑blocker drops (e.g., timolol) that decrease fluid production via a different pathway, and prostaglandin analogues (e.g., latanoprost) that increase outflow. Choice depends on efficacy, tolerance, and patient‑specific factors.

Store Itoco at room temperature, preferably below 25 °C. Keep the bottle tightly closed, in its original packaging, and protect it from light and moisture. Do not freeze the solution, and discard any product that appears discolored or contaminated.

Itoco is applied as an ophthalmic solution. The patient should wash hands, tilt the head back, pull down the lower eyelid, and instill the prescribed number of drops into the conjunctival sac. Avoid touching the tip of the bottle to the eye or any surface to maintain sterility.

Serious risks include severe allergic reactions such as Stevens‑Johnson syndrome, corneal edema, and persistent ocular pain. If any signs of a serious reaction occur—such as rash, swelling, vision changes, or severe eye discomfort—immediate medical attention is required.

Itoco should not be used by individuals with a known hypersensitivity to dorzolamide, sulfonamides, or any component of the formulation. Patients with severe corneal disease or those using other carbonic anhydrase inhibitor eye drops without medical guidance should also avoid it.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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