Product image of Itoco (Dorzolamide) supplied by GNH India

Itoco

Active Ingredient:
Dorzolamide
Origin:
EU

Itoco (Dorzolamide)

Dorzolamide, the active ingredient in Itoco, is a carbonic anhydrase inhibitor presented as a topical ophthalmic solution for ocular (topical) use. It lowers intra‑ocular pressure and is employed in the management of glaucoma and ocular hypertension, particularly in patients with primary open‑angle glaucoma, helping to preserve visual function.

GNH India supplies Itoco as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide, providing reliable access to quality‑assured ophthalmic medicines for diverse healthcare markets and supporting patient care.

Manufacturer / TM Owner

Farmaprojects S.A.U.

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Indications & Clinical Uses

Dorzolamide is used to reduce intra‑ocular pressure in glaucoma‑related conditions.

  • Primary open‑angle glaucoma: lowers intra‑ocular pressure to help prevent optic nerve damage.
  • Ocular hypertension: reduces elevated eye pressure to decrease risk of progression to glaucoma.
  • Secondary glaucoma: used as adjunct therapy when other treatments are insufficient to control pressure.

How It Works

  • Dorzolamide inhibits carbonic anhydrase enzymes in the ciliary body epithelium, decreasing the formation of aqueous humor. This reduction in fluid production leads to lower intra‑ocular pressure, helping to protect the optic nerve and preserve visual function in glaucoma and ocular hypertension.

Side Effects

Adverse reactions may occur with topical dorzolamide use.

Common Side Effects

  • Eye burning or stinging
  • Transient blurred vision
  • Metallic taste alteration
  • Redness of the eye

Serious or Rare Side Effects

  • Severe allergic reaction, including angioedema or anaphylaxis
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis

Precautions & Warnings

When prescribing dorzolamide, consider the following precautions.

  • Assess intra‑ocular pressure before initiating: monitor regularly during therapy.
  • Avoid in patients with sulfonamide hypersensitivity: consider alternative treatment.
  • Use with caution in severe renal impairment: adjust therapy as needed.
  • Do not combine with other carbonic anhydrase inhibitors without supervision: risk of additive IOP lowering.
  • Discontinue if severe ocular irritation occurs: seek medical advice promptly.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Dorzolamide may interact with other ocular or systemic agents.

Major Interactions (Avoid)

  • Systemic carbonic anhydrase inhibitors (e.g., acetazolamide): increased risk of systemic acidosis.
  • Topical beta‑blockers (e.g., timolol): additive systemic side effects.

Moderate Interactions (Monitor Closely)

  • Topical prostaglandin analogs: may enhance intra‑ocular pressure reduction, monitor pressure.
  • Topical corticosteroids: may reduce dorzolamide efficacy.
  • Systemic sulfonamides: potential hypersensitivity cross‑reaction.

Frequently Asked Questions

Itoco contains dorzolamide, which is prescribed to lower intra‑ocular pressure in patients with primary open‑angle glaucoma or ocular hypertension. By reducing eye pressure, it helps to prevent optic nerve damage and preserve visual function.

Dorzolamide blocks carbonic anhydrase enzymes in the ciliary body of the eye. This inhibition reduces the production of aqueous humor, the fluid that maintains eye pressure, thereby lowering intra‑ocular pressure and mitigating the risk of glaucoma progression.

The specific dosing regimen for Itoco is determined by the prescribing clinician. Typically, one drop is instilled in the affected eye(s) two to three times daily, but the exact frequency and duration are individualized based on the patient’s condition and response.

Safety data for dorzolamide in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To order Itoco, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Itoco (dorzolamide) belongs to the carbonic anhydrase inhibitor class, whereas many alternatives such as timolol are beta‑blockers. Dorzolamide reduces aqueous humor production, while beta‑blockers decrease its secretion. Choice of therapy depends on patient tolerance, comorbidities, and desired IOP‑lowering profile.

Itoco should be stored at room temperature, ideally below 25 °C, in its original container. Protect the bottle from light and moisture, and keep it out of reach of children. Do not freeze the solution.

Itoco is applied as an eye drop. The patient should wash hands, tilt the head back, pull down the lower eyelid, and place a single drop into the conjunctival sac. Avoid touching the dropper tip to the eye or any surface to maintain sterility.

The most serious adverse reactions include severe allergic responses such as angioedema or anaphylaxis, and rare skin conditions like Stevens‑Johnson syndrome. If any signs of a severe reaction appear—such as swelling, rash, or sudden vision loss—seek immediate medical attention.

Itoco should be avoided in individuals with a known hypersensitivity to dorzolamide, other sulfonamides, or any component of the formulation. Patients with severe renal impairment should use it only under close medical supervision, and those on conflicting ocular medications should be evaluated by a clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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