Product image of Itoco (Dorzolamide) supplied by GNH India

Itoco

Active Ingredient:
Dorzolamide
Origin:
EU

Itoco (Dorzolamide)

Dorzolamide, the active ingredient in Itoco, is a carbonic anhydrase inhibitor presented as an ophthalmic solution for ocular use. It is used to lower intra‑ocular pressure in patients with open‑angle glaucoma or ocular hypertension.

GNH India supplies Itoco as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Trb Chemedica (Austria) Gmbh

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Indications & Clinical Uses

  • Dorzolamide is employed in the management of glaucoma‑related conditions to reduce intra‑ocular pressure.
  • Open‑angle glaucoma: lowers intra‑ocular pressure to prevent optic nerve damage.
  • Ocular hypertension: reduces eye pressure to lower the risk of developing glaucoma.
  • Secondary glaucoma: helps control pressure when other causes elevate intra‑ocular fluid.

How It Works

  • Dorzolamide inhibits carbonic anhydrase enzymes located in the ciliary body of the eye. By blocking this enzyme, the production of aqueous humor is reduced, leading to a decrease in intra‑ocular pressure and helping to prevent damage to the optic nerve associated with glaucoma.

Side Effects

Dorzolamide may cause a range of ocular and systemic reactions.

Common Side Effects

  • Eye irritation or burning sensation.
  • Bitter taste after instillation.
  • Blurred vision temporarily.
  • Headache.
  • Conjunctival hyperemia.
  • Ocular discomfort.

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angio‑edema, anaphylaxis).
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Corneal edema or ulceration.
  • Significant vision loss.
  • Persistent ocular inflammation.

Precautions & Warnings

  • When prescribing or using dorzolamide, consider the following safety measures.
  • Assess renal function: adjust use in patients with severe renal impairment.
  • Monitor intra‑ocular pressure: ensure therapeutic response and adjust therapy as needed.
  • Avoid in sulfonamide‑allergic patients: consider alternative agents.
  • Inform patients about transient visual disturbances: advise reporting persistent changes.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Dorzolamide can interact with other ocular or systemic medications.

Major Interactions (Avoid)

  • Acetazolamide: additive intra‑ocular pressure‑lowering effect may cause excessive reduction.
  • Topical beta‑blockers: combined use can lead to overly low ocular pressure.

Moderate Interactions (Monitor Closely)

  • Systemic sulfonamides: potential cross‑reactivity; monitor for allergic signs.
  • Prostaglandin analogues: may influence overall pressure‑lowering efficacy; observe IOP.
  • Anticholinergic eye drops: may increase ocular irritation; assess patient comfort.

Frequently Asked Questions

Itoco contains dorzolamide, which is used to lower intra‑ocular pressure in patients with open‑angle glaucoma or ocular hypertension. Reducing pressure helps protect the optic nerve and prevent vision loss associated with these eye conditions.

Dorzolamide blocks carbonic anhydrase enzymes in the ciliary body of the eye. This inhibition reduces the production of aqueous humor, the fluid that maintains eye pressure, thereby lowering intra‑ocular pressure and helping to control glaucoma.

The dosing regimen for Itoco is determined by the prescribing eye specialist. Typically, one drop is instilled in the affected eye(s) one to two times daily, but the exact schedule should follow the clinician’s instructions.

Safety data for dorzolamide in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To request Itoco, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Itoco (dorzolamide) belongs to the carbonic anhydrase inhibitor class, which reduces aqueous humor production. Compared with beta‑blocker eye drops, it works via a different mechanism and may be combined for additive effect. Unlike prostaglandin analogues that increase outflow, dorzolamide focuses on decreasing fluid formation.

Itoco should be stored at room temperature, below 25 °C, in its original packaging. Keep the bottle tightly closed, protect it from direct sunlight and moisture to maintain stability and potency.

Itoco is applied as an ophthalmic solution. The patient places the prescribed number of drops into the affected eye(s) as directed by the eye care professional, typically avoiding contact with the eyelid or eyelashes and washing hands before and after use.

Serious risks include severe allergic reactions such as angio‑edema or anaphylaxis, and rare dermatologic conditions like Stevens‑Johnson syndrome. Any signs of swelling, rash, or sudden vision changes should prompt immediate medical attention.

Patients with a known hypersensitivity to dorzolamide, sulfonamides, or any component of the formulation should avoid Itoco. Additionally, individuals with severe renal impairment or those who cannot safely administer eye drops should discuss alternatives with their clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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