Product image of Itokin (Itopride Hydrochloride) supplied by GNH India

Itokin

Active Ingredient:
Itopride Hydrochloride
Origin:
EU

Itokin (Itopride Hydrochloride)

Itopride Hydrochloride, the active ingredient in Itokin, is a prokinetic presented as a oral formulation for oral use. It treats functional dyspepsia, gastroesophageal reflux disease and gastric motility disorders in adults.
GNH India supplies Itokin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Biofarm Sp. Z O.O.

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Indications & Clinical Uses

  • Itokin is a prokinetic agent that acts on gastrointestinal motility disorders.
  • Functional dyspepsia: improves upper abdominal discomfort and early satiety by enhancing gastric emptying.
  • Gastroesophageal reflux disease: reduces reflux episodes by promoting coordinated esophageal clearance.
  • Gastric motility disorders: facilitates gastric emptying and intestinal transit, alleviating symptoms of delayed gastric emptying.

How It Works

  • Itopride Hydrochloride exerts its prokinetic effect by antagonizing dopamine D2 receptors in the gastrointestinal tract and inhibiting acetylcholinesterase, which increases acetylcholine availability. The combined action enhances cholinergic stimulation of smooth muscle, leading to increased gastric motility and accelerated gastric emptying.

Side Effects

Adverse reactions may occur with Itokin use.

Common Side Effects

  • Nausea
  • Diarrhea
  • Abdominal pain or discomfort
  • Headache
  • Dry mouth
  • Dizziness

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis, rash, swelling)
  • Extrapyramidal symptoms (tremor, rigidity)
  • Cardiac arrhythmia
  • Hepatic injury or elevated liver enzymes
  • Persistent vomiting or severe dehydration

Precautions & Warnings

  • Before initiating therapy, consider the following precautions.
  • Assess renal function: adjust use in patients with significant renal impairment.
  • Monitor for allergic reactions: discontinue if signs of hypersensitivity appear.
  • Use caution in cardiac disease: prokinetic activity may affect heart rate or rhythm.
  • Avoid in known hypersensitivity to itopride or excipients.
  • Pregnancy and breastfeeding: consult a physician before use.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Itokin may interact with other medications; review patient medication lists.

Major Interactions (Avoid)

  • Anticholinergic agents: may diminish prokinetic efficacy.
  • Strong CYP3A4 inhibitors: could increase plasma concentrations of itopride.

Moderate Interactions (Monitor Closely)

  • Antacids: may reduce absorption if taken simultaneously.
  • Macrolide antibiotics: additive gastrointestinal effects possible.
  • Metoclopramide: combined dopaminergic antagonism may increase risk of extrapyramidal symptoms.

Frequently Asked Questions

Itokin contains itopride hydrochloride and is indicated for functional dyspepsia, gastroesophageal reflux disease, and other gastric motility disorders where enhanced gastrointestinal movement can relieve symptoms such as upper abdominal discomfort, early satiety, and reflux.

Itopride acts by blocking dopamine D2 receptors in the gut and inhibiting acetylcholinesterase. This dual action raises acetylcholine levels, stimulating smooth‑muscle contraction and promoting coordinated gastric emptying and intestinal transit.

The dosage of Itokin is determined by the prescribing healthcare professional based on the individual’s condition, age, renal function and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for itopride in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their physician before starting Itokin.

To request Itokin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Itokin (itopride) differs from agents such as metoclopramide by combining dopamine D2 antagonism with acetylcholinesterase inhibition, which may result in a favorable side‑effect profile and effective gastric motility enhancement. Choice of therapy depends on clinical response, tolerability and physician judgment.

Itokin should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date.

Itokin is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare professional. Timing relative to meals may be advised by the prescriber.

Serious adverse events, although rare, can include severe allergic reactions such as anaphylaxis, extrapyramidal symptoms like tremor or rigidity, cardiac arrhythmias, and significant liver injury. Patients should seek immediate medical attention if they experience any of these symptoms.

Itokin is contraindicated in individuals with known hypersensitivity to itopride hydrochloride or any of the tablet’s excipients. Caution is also advised for patients with severe cardiac disease, uncontrolled hepatic impairment, or those taking medications that may cause dangerous interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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