Product image of Itomed (Itopride Hydrochloride) supplied by GNH India

Itomed

Active Ingredient:
Itopride Hydrochloride
Origin:
EU

Itomed (Itopride Hydrochloride)

Itopride Hydrochloride, the active ingredient in Itomed, is a prokinetic presented as an oral tablet for oral use. It treats functional dyspepsia, gastroesophageal reflux disease and gastric motility disorders in adults, and is indicated for patients experiencing upper gastrointestinal discomfort.

GNH India supplies Itomed as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide across Europe and other markets.

Manufacturer / TM Owner

Kappler Pharma Consult Gmbh

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Indications & Clinical Uses

Itopride Hydrochloride is used to improve gastrointestinal motility in several functional disorders.

  • Functional dyspepsia: alleviates post‑prandial fullness, early satiety and upper abdominal discomfort.
  • Gastroesophageal reflux disease (GERD): reduces reflux episodes by enhancing esophageal clearance.
  • Gastric motility disorders: promotes gastric emptying and improves related symptoms.

How It Works

  • Itopride Hydrochloride acts by antagonizing dopamine D2 receptors in the gastrointestinal tract, which removes inhibitory dopaminergic tone on smooth muscle. Simultaneously, it inhibits acetylcholinesterase, leading to increased acetylcholine levels that stimulate muscarinic receptors, thereby enhancing coordinated gastric and intestinal motility.

Side Effects

Itopride Hydrochloride may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea
  • Headache
  • Dry mouth
  • Abdominal cramps
  • Dizziness
  • Diarrhea

Serious or Rare Side Effects

  • Severe allergic reactions (anaphylaxis, rash, swelling)
  • Cardiac arrhythmias
  • Extrapyramidal symptoms
  • Hepatic injury
  • Significant hypotension

Precautions & Warnings

When prescribing Itopride Hydrochloride, consider the following precautions to ensure safe use.

  • Assess renal function: evaluate kidney status before initiating therapy.
  • Monitor hepatic function: use with caution in patients with liver impairment.
  • Check for hypersensitivity: discontinue if allergic reactions occur.
  • Avoid concomitant dopamine antagonists: may reduce prokinetic effect.
  • Pregnancy and lactation: safety not established; weigh benefits and risks.
  • Store at room temperature: keep in original container, protect from moisture.

Avoid Interactions

Itopride Hydrochloride can interact with other medicines; notable interactions are grouped by clinical significance.

Major Interactions (Avoid)

  • Antipsychotics (dopamine D2 antagonists): may counteract prokinetic activity.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): can increase plasma concentrations.
  • Monoamine oxidase inhibitors: risk of hypertensive events.

Moderate Interactions (Monitor Closely)

  • Anticholinergic agents: may diminish therapeutic effect.
  • Macrolide antibiotics (e.g., erythromycin): additive prokinetic action may cause excess GI stimulation.
  • Serotonergic drugs (e.g., SSRIs): monitor for potential serotonin‑related adverse effects.

Frequently Asked Questions

Itomed contains Itopride Hydrochloride and is indicated for functional dyspepsia, gastroesophageal reflux disease (GERD) and other gastric motility disorders where enhancing gastrointestinal movement can relieve symptoms such as fullness, nausea and reflux.

Itopride Hydrochloride works by blocking dopamine D2 receptors in the gut, which removes an inhibitory signal on smooth‑muscle contraction. At the same time it inhibits acetylcholinesterase, raising acetylcholine levels and stimulating muscarinic receptors, together promoting coordinated gastric and intestinal motility.

The dosage of Itomed is determined by the prescribing healthcare professional based on the patient’s condition, age, renal and hepatic function, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose without medical advice.

Safety data for Itopride Hydrochloride in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by the treating physician after a thorough risk‑benefit assessment.

To order Itomed, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Itomed (Itopride Hydrochloride) differs from other prokinetics such as metoclopramide or domperidone by combining dopamine‑D2 antagonism with acetylcholinesterase inhibition, which may provide a broader stimulatory effect on gut motility while having a distinct side‑effect profile. Choice of agent depends on clinical response, tolerability and individual patient factors.

Itomed should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

Itomed is taken orally, usually with a glass of water. The tablet should be swallowed whole and can be taken with or without food, unless the prescriber provides specific instructions regarding timing relative to meals.

Serious risks, although rare, include severe allergic reactions such as anaphylaxis, cardiac arrhythmias, extrapyramidal symptoms, significant hypotension and hepatic injury. Patients should seek immediate medical attention if they experience signs of these conditions.

Itomed should be avoided in individuals with known hypersensitivity to Itopride Hydrochloride or any excipients, in patients taking other dopamine‑D2 antagonists that could blunt its effect, and in those with uncontrolled cardiac arrhythmias or severe liver disease unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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