Product image of Itoprid Pmcs (Itopride Hydrochloride) supplied by GNH India

Itoprid Pmcs

Active Ingredient:
Itopride Hydrochloride
Origin:
EU

Itoprid Pmcs (Itopride Hydrochloride)

Itopride Hydrochloride, the active ingredient in Itoprid Pmcs, is a prokinetic (gastroprokinetic) presented as an oral formulation for oral use. It is employed to relieve symptoms of functional dyspepsia, gastro‑oesophageal reflux disease and other gastric motility disorders in adult patients.
GNH India supplies Itoprid Pmcs as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pro.Med.Cs Praha A.S.

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Indications & Clinical Uses

Itoprid Pmcs is a gastroprokinetic that acts on upper‑gastrointestinal motility disorders.

  • Functional dyspepsia: improves post‑prandial fullness and upper abdominal discomfort.
  • Gastro‑oesophageal reflux disease: reduces reflux episodes and associated heartburn.
  • Gastric motility disorders: enhances gastric emptying and alleviates delayed gastric transit.

How It Works

  • Itopride Hydrochloride exerts its prokinetic effect by antagonising dopamine D2 receptors in the gastrointestinal tract, which removes inhibitory dopaminergic tone on smooth‑muscle contraction. Concurrently, it inhibits acetylcholinesterase, increasing acetylcholine availability and stimulating cholinergic pathways that promote coordinated peristalsis and accelerated gastric emptying.

Side Effects

Adverse reactions may occur with any medication and should be monitored.

Common Side Effects

  • Nausea
  • Diarrhoea
  • Abdominal cramps
  • Headache
  • Dry mouth
  • Dizziness

Serious or Rare Side Effects

  • Anaphylactic reaction or severe skin rash
  • Cardiac arrhythmia
  • Elevated liver enzymes
  • Neutropenia or other blood dyscrasias
  • Pancreatitis
  • Severe hypotension

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Renal function assessment: adjust use in severe impairment.
  • Hepatic monitoring: observe for enzyme elevation.
  • Elderly patients: start with lowest effective dose.
  • Known hypersensitivity: avoid if allergic to itopride or excipients.
  • Concomitant dopamine antagonists: evaluate risk of additive effects.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Itopride may interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Anticholinergic agents: may diminish prokinetic efficacy.
  • Other dopamine antagonists (e.g., metoclopramide): increased risk of extrapyramidal symptoms.
  • MAO inhibitors: potential for hypertensive crisis.

Moderate Interactions (Monitor Closely)

  • Antacids or aluminium‑containing preparations: may reduce absorption.
  • H2‑receptor antagonists and proton‑pump inhibitors: possible attenuation of effect.
  • CYP3A4 substrates: monitor for altered plasma levels.
  • NSAIDs: heightened gastrointestinal irritation risk.

Frequently Asked Questions

Itoprid Pmcs, containing itopride hydrochloride, is indicated for functional dyspepsia, gastro‑oesophageal reflux disease and other gastric motility disorders where enhancing gastrointestinal transit can relieve symptoms such as fullness, heartburn and delayed gastric emptying.

Itopride acts by blocking dopamine D2 receptors in the gut, removing an inhibitory signal on smooth‑muscle contraction, while also inhibiting acetylcholinesterase. The resulting increase in acetylcholine stimulates cholinergic pathways, promoting coordinated peristalsis and faster gastric emptying.

The prescribed dose of Itoprid Pmcs is determined by the treating physician based on the patient’s clinical condition, age, renal and hepatic function, and response to therapy. Dosage instructions should always follow the prescriber’s recommendation.

Safety data for itopride during pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with other prokinetics such as metoclopramide or domperidone, itopride has a dual mechanism—dopamine antagonism plus acetylcholinesterase inhibition—which may offer a broader enhancement of gut motility while having a lower risk of extrapyramidal side effects. Clinical choice depends on patient profile and physician judgment.

Itoprid Pmcs should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Itoprid Pmcs is taken orally, usually with or without food, as directed by the prescribing clinician. The tablet (or other oral form) should be swallowed whole with water and not crushed or chewed unless specifically instructed.

Serious adverse events, although rare, can include severe allergic reactions such as anaphylaxis, cardiac arrhythmias, significant liver enzyme elevations, neutropenia, and pancreatitis. Patients should seek immediate medical attention if they experience symptoms like rash, difficulty breathing, chest pain, jaundice or unexplained fever.

Itoprid Pmcs is contraindicated in individuals with known hypersensitivity to itopride or any of the product’s excipients. Caution is advised for patients with severe renal or hepatic impairment, those taking other dopamine antagonists, and patients with a history of cardiac arrhythmias until evaluated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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