Product image of Itopride Pmcs (Itopride Hydrochloride) supplied by GNH India

Itopride Pmcs

Active Ingredient:
Itopride Hydrochloride
Origin:
EU

Itopride Pmcs (Itopride Hydrochloride)

Itopride Hydrochloride, the active ingredient in Itopride Pmcs, is a prokinetic agent presented as an oral dosage form for oral use. It is used to improve gastrointestinal motility in adults with functional dyspepsia, gastro‑oesophageal reflux disease and gastroparesis.

GNH India supplies Itopride Pmcs as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pro.Med.Cs Praha A.S.

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Indications & Clinical Uses

  • Itopride Hydrochloride acts on gastrointestinal motility disorders to relieve upper‑GI symptoms.
  • Functional dyspepsia: improves early satiety, post‑prandial fullness and epigastric discomfort.
  • Gastro‑oesophageal reflux disease: reduces reflux episodes and heartburn by enhancing gastric emptying.
  • Gastroparesis: accelerates gastric emptying and alleviates nausea, vomiting and bloating associated with delayed gastric transit.

How It Works

  • Itopride Hydrochloride antagonizes dopamine D2 receptors in the gastrointestinal tract and inhibits acetylcholinesterase, leading to increased acetylcholine release. The combined dopaminergic blockade and cholinergic enhancement promote coordinated smooth‑muscle contractions, thereby accelerating gastric emptying and improving overall gastrointestinal motility.

Side Effects

Adverse reactions may occur with Itopride Hydrochloride use.

Common Side Effects

  • Nausea
  • Diarrhoea
  • Abdominal pain or discomfort
  • Headache
  • Dry mouth
  • Dizziness

Serious or Rare Side Effects

  • Extrapyramidal symptoms such as tremor or rigidity
  • Severe allergic reactions including rash, angioedema or anaphylaxis
  • Cardiac arrhythmias
  • Hepatic dysfunction indicated by elevated liver enzymes
  • Neutropenia or other blood dyscrasias

Precautions & Warnings

  • Before initiating therapy, consider the following precautions.
  • Assess renal function: adjust use in patients with severe impairment.
  • Monitor for gastrointestinal symptoms: evaluate efficacy and tolerability.
  • Avoid in patients with known hypersensitivity to itopride or excipients.
  • Use caution in pregnancy: limited safety data are available; weigh benefits against potential risks.
  • Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Itopride Hydrochloride may interact with other medicines; review patient medication lists.

Major Interactions (Avoid)

  • Concomitant use with strong dopamine D2 antagonists (e.g., certain antipsychotics) may blunt prokinetic effect.
  • Combination with other prokinetic agents can lead to excessive cholinergic activity.

Moderate Interactions (Monitor Closely)

  • Metoclopramide: monitor for additive gastrointestinal effects.
  • Anticholinergic drugs: may reduce itopride efficacy.
  • CYP enzyme inhibitors: may increase plasma concentrations of itopride, requiring observation.

Frequently Asked Questions

Itopride Pmcs contains itopride hydrochloride, a prokinetic agent indicated for functional dyspepsia, gastro‑oesophageal reflux disease and gastroparesis. In these disorders it helps improve gastric emptying and reduces upper‑GI symptoms such as nausea, early satiety and heartburn.

Itopride hydrochloride works by blocking dopamine D2 receptors in the gut and inhibiting acetylcholinesterase. This dual action raises acetylcholine levels, stimulating smooth‑muscle contractions and promoting coordinated gastric motility, which speeds gastric emptying and relieves related symptoms.

The appropriate dose of Itopride Pmcs is determined by the prescribing healthcare professional based on the patient’s condition, age, renal function and other clinical factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for itopride hydrochloride in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Itopride differs from many prokinetics by combining dopamine D2 antagonism with acetylcholinesterase inhibition, offering a balanced increase in acetylcholine without strong anticholinergic effects. Compared with metoclopramide, itopride has a lower risk of extrapyramidal side effects, while providing comparable enhancement of gastric motility.

Itopride Pmcs should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Itopride Pmcs is taken orally, usually with a glass of water. The tablet should be swallowed whole and not chewed or crushed, unless otherwise directed by a healthcare professional.

Serious but rare risks include extrapyramidal symptoms such as tremor or rigidity, severe allergic reactions (rash, angioedema, anaphylaxis), cardiac arrhythmias, hepatic dysfunction and blood dyscrasias like neutropenia. Patients should seek immediate medical attention if any of these occur.

Itopride Pmcs should be avoided in individuals with known hypersensitivity to itopride hydrochloride or any excipients, and in patients where a strong dopamine D2 antagonist is required for other conditions. Caution is also advised for those with severe renal impairment or uncontrolled cardiac disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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