Product image of Itoprom (Itopride Hydrochloride) supplied by GNH India

Itoprom

Active Ingredient:
Itopride Hydrochloride
Origin:
EU

Itoprom (Itopride Hydrochloride)

Itopride Hydrochloride, the active ingredient in Itoprom, is a prokinetic presented as a tablet for oral use. It enhances gastrointestinal motility and is used to relieve symptoms of functional dyspepsia, gastro‑oesophageal reflux disease and other motility disorders in adults.
GNH India supplies Itoprom as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pro.Med.Cs Praha A.S.

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Indications & Clinical Uses

Itoprom is a prokinetic agent that acts on gastrointestinal motility disorders.

  • Functional dyspepsia: improves upper‑abdominal discomfort and early satiety by accelerating gastric emptying.
  • Gastro‑oesophageal reflux disease (GERD): reduces reflux episodes through enhanced oesophageal clearance.
  • Gastrointestinal motility disorders: restores coordinated intestinal movement, alleviating bloating and irregular bowel habits.

How It Works

  • Itopride Hydrochloride exerts its prokinetic effect by antagonizing dopamine D2 receptors in the gastrointestinal tract, which removes inhibitory dopaminergic tone on smooth‑muscle contraction. Concurrently, it inhibits acetylcholinesterase, increasing acetylcholine availability and further stimulating cholinergic pathways that promote coordinated gastric and intestinal motility.

Side Effects

Adverse reactions may occur with any prokinetic therapy and should be monitored.

Common Side Effects

  • Nausea: mild to moderate feeling of queasiness.
  • Diarrhea: loose stools occurring intermittently.
  • Abdominal pain: cramping or discomfort in the stomach area.
  • Headache: transient mild to moderate pain.
  • Dry mouth: reduced salivation.
  • Dizziness: sensation of light‑headedness.

Serious or Rare Side Effects

  • Extrapyramidal symptoms: involuntary muscle movements or tremor.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Elevated liver enzymes: indication of hepatic stress.
  • Cardiac arrhythmia: irregular heart rhythm.
  • Neutropenia: reduced white blood cell count.
  • Anaphylactic shock: life‑threatening systemic reaction.

Precautions & Warnings

Before initiating therapy, certain safety considerations are recommended.

  • Pregnancy: consult a physician; benefits must outweigh potential risks.
  • Breastfeeding: use with caution; monitor infant for adverse effects.
  • Renal impairment: dose adjustment may be required based on renal function.
  • Elderly patients: monitor closely for increased sensitivity to side effects.
  • Drug interactions: review all concomitant medications for potential interactions.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Itoprom may interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Antipsychotics (e.g., haloperidol): may diminish prokinetic activity and increase dopaminergic imbalance.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): can raise plasma concentrations, heightening adverse effects.
  • Concurrent prokinetics (e.g., metoclopramide): risk of additive gastrointestinal stimulation and neurological side effects.

Moderate Interactions (Monitor Closely)

  • Antacids: may reduce absorption; separate administration by at least 2 hours.
  • Macrolide antibiotics (e.g., erythromycin): potential synergistic increase in gut motility.
  • Warfarin: monitor INR values for possible anticoagulant effect alteration.
  • Diuretics: watch electrolyte balance, especially potassium, due to enhanced GI loss.

Frequently Asked Questions

Itoprom, containing Itopride Hydrochloride, is prescribed for functional dyspepsia, gastro‑oesophageal reflux disease (GERD) and other gastrointestinal motility disorders where enhanced gastric emptying and coordinated intestinal movement can relieve symptoms such as bloating, early satiety and reflux.

Itopride Hydrochloride works by blocking dopamine D2 receptors in the gut, removing an inhibitory signal that slows muscle contraction. At the same time it inhibits acetylcholinesterase, raising acetylcholine levels and stimulating cholinergic pathways that promote stronger, more coordinated gastrointestinal motility.

The exact dosage of Itoprom is determined by the prescribing clinician based on the patient’s condition, age, renal function and other individual factors. Healthcare professionals tailor the regimen to achieve optimal symptom control while minimizing potential adverse effects.

Safety data for Itoprom in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider after a thorough risk‑benefit assessment.

To place an order, submit an enquiry on the Itoprom product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with older prokinetics such as metoclopramide, Itoprom offers a dual mechanism—dopamine antagonism and acetylcholinesterase inhibition—potentially providing effective motility enhancement with a lower risk of extrapyramidal side effects. However, individual response varies and clinicians choose therapy based on patient profile and tolerability.

Itoprom should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, excessive heat and direct sunlight to maintain stability and potency throughout its shelf life.

Itoprom is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed, unless the prescribing information advises otherwise. Dosing times are set by the prescriber to align with meals or specific symptom patterns.

Serious risks, though rare, include extrapyramidal symptoms such as tremor or rigidity, severe allergic reactions like anaphylaxis, significant liver enzyme elevations, and cardiac arrhythmias. Patients should seek immediate medical attention if they experience unexplained muscle movements, rash, breathing difficulty, jaundice or palpitations.

Itoprom is contraindicated in individuals with known hypersensitivity to Itopride Hydrochloride or any tablet excipients. Patients with severe hepatic impairment, uncontrolled cardiac arrhythmias, or those taking medications that strongly interact with dopamine pathways should avoid use unless closely supervised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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