Product image of Itoprom (Itopride Hydrochloride) supplied by GNH India

Itoprom

Active Ingredient:
Itopride Hydrochloride
Origin:
EU

Itoprom (Itopride Hydrochloride)

Itopride hydrochloride, the active ingredient in Itoprom, is a prokinetic agent presented as an oral dosage form for oral use. It is employed to improve gastrointestinal motility in adults with functional dyspepsia, gastro‑oesophageal reflux disease, and gastroparesis.

GNH India supplies Itoprom as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable supply chain solutions across multiple regions.

Manufacturer / TM Owner

Pro.Med.Cs Praha A.S.

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Indications & Clinical Uses

Itopride hydrochloride is indicated for several gastrointestinal motility disorders where impaired gastric emptying contributes to symptoms.

  • Functional dyspepsia: alleviates post‑prandial fullness, early satiety and epigastric discomfort by enhancing gastric emptying.
  • Gastroesophageal reflux disease (GERD): reduces reflux episodes and heartburn by promoting coordinated esophageal and gastric motility.
  • Gastroparesis: improves gastric emptying rates, thereby decreasing nausea, vomiting and bloating in patients with delayed gastric transit.

How It Works

  • Itopride hydrochloride acts by antagonizing dopamine D2 receptors in the gastrointestinal tract, which removes inhibitory dopaminergic tone on smooth‑muscle contraction. Concurrently, it stimulates acetylcholine release from enteric neurons, enhancing cholinergic activity. The combined effect accelerates gastric emptying and improves coordinated intestinal motility.

Side Effects

Adverse reactions to Itopride hydrochloride are generally mild but can vary in frequency and severity.

Common Side Effects

  • Nausea: mild, transient feeling of queasiness.
  • Diarrhea: loose stools occurring intermittently.
  • Abdominal cramps: discomfort or pain in the stomach area.
  • Headache: mild to moderate head pain.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Extrapyramidal symptoms: involuntary muscle movements or tremor.
  • Severe allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Cardiac arrhythmia: irregular heart rhythm reported rarely.
  • Elevated liver enzymes: signs of hepatic stress observed in laboratory tests.

Precautions & Warnings

When prescribing Itopride hydrochloride, clinicians should consider several safety aspects.

  • Assess renal and hepatic function: adjust use if significant impairment is present.
  • Monitor for extrapyramidal symptoms: observe patients for tremor or involuntary movements.
  • Avoid in known hypersensitivity: discontinue if allergic reactions occur.
  • Caution in pregnancy: safety data are limited; use only if benefit outweighs risk.
  • Use carefully in elderly patients: increased susceptibility to side effects.
  • Store at ambient temperature below 25°C: keep in original packaging, protect from moisture.

Avoid Interactions

Itopride hydrochloride may interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Strong dopamine antagonists (e.g., antipsychotics): may diminish prokinetic effect.
  • Anticholinergic agents: can counteract acetylcholine‑mediated action.
  • Other prokinetic drugs: additive gastrointestinal stimulation may increase adverse events.

Moderate Interactions (Monitor Closely)

  • Dopamine agonists (e.g., levodopa): potential reduction in therapeutic effect.
  • CYP2D6 substrates: possible altered metabolism requiring observation.
  • Antihistamines with anticholinergic properties: may lessen efficacy.

Frequently Asked Questions

Itoprom contains itopride hydrochloride, a prokinetic agent used to treat functional dyspepsia, gastro‑oesophageal reflux disease and gastroparesis by enhancing gastrointestinal motility. It is prescribed for adults with symptoms related to delayed gastric emptying.

Itopride blocks dopamine D2 receptors in the gut, removing inhibitory dopaminergic influence, and simultaneously stimulates acetylcholine release from enteric neurons. This dual action increases smooth‑muscle contraction, accelerates gastric emptying, and improves coordinated intestinal movement.

The dosage of Itoprom is individualized by the prescribing healthcare professional based on the patient’s condition, severity, and response. Physicians determine the appropriate strength, frequency and duration according to clinical guidelines and patient factors.

Safety data for itopride during pregnancy and lactation are limited. Itoprom should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified prescriber.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with alternatives such as metoclopramide, itopride has a lower risk of central nervous system side effects because it does not readily cross the blood‑brain barrier. Its dual dopamine antagonism and acetylcholine stimulation provide effective motility enhancement while maintaining a favorable safety profile in many patients.

Itoprom should be stored at ambient temperature below 25 °C, in its original packaging to protect from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments to maintain stability.

Itoprom is taken orally, usually with or without food, as directed by the prescribing clinician. The tablet should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed. Adherence to the prescribed schedule ensures optimal therapeutic effect.

Although uncommon, serious adverse reactions can include extrapyramidal symptoms such as tremor or dystonia, severe allergic responses including anaphylaxis, and rare cardiac arrhythmias. Patients should seek immediate medical attention if they experience any of these symptoms.

Itoprom is contraindicated in individuals with known hypersensitivity to itopride hydrochloride or any excipients, and should be avoided in patients with severe hepatic or renal impairment unless closely monitored. Caution is also advised for those taking interacting medications listed under major interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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