Product image of Itraconazol Al (Itraconazole) supplied by GNH India

Itraconazol Al

Active Ingredient:
Itraconazole
Origin:
EU

Itraconazol Al (Itraconazole)

Itraconazole, the active ingredient in Itraconazol Al, is a azole antifungal presented as an oral formulation for systemic use. It treats a range of fungal infections in adults and children as prescribed.

GNH India supplies Itraconazol Al as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aliud Pharma Gmbh

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Indications & Clinical Uses

Itraconazole is an azole antifungal used to treat systemic and superficial fungal infections.

  • Dermatophyte infections: reduces skin and nail fungal growth.
  • Onychomycosis: clears fungal infection of the nails.
  • Systemic candidiasis: treats invasive Candida infections.
  • Aspergillosis: manages chronic pulmonary aspergillosis.
  • Blastomycosis: combats Blastomyces dermatitidis infection.

How It Works

  • Itraconazole inhibits the fungal cytochrome P450 enzyme lanosterol 14α‑demethylase, blocking conversion of lanosterol to ergosterol. This disruption impairs ergosterol synthesis, a key component of fungal cell membranes, leading to increased membrane permeability and inhibition of fungal growth.

Side Effects

Common side effects of itraconazole are generally mild and reversible.

Common Side Effects

  • Nausea
  • Vomiting
  • Abdominal pain
  • Headache
  • Rash
  • Altered taste perception

Serious or Rare Side Effects

  • Hepatotoxicity (elevated liver enzymes, hepatitis)
  • Severe skin reactions (Stevens‑Johnson syndrome, toxic epidermal necrolysis)
  • Congestive heart failure
  • QT interval prolongation
  • Anaphylactic reactions
  • Acute interstitial nephritis

Precautions & Warnings

Itraconazole requires careful monitoring due to its pharmacologic profile.

  • Liver function monitoring: assess hepatic enzymes before and during therapy.
  • Drug interaction vigilance: avoid concomitant use with strong CYP3A4 inducers.
  • Pregnancy risk: contraindicated in pregnancy (Category D).
  • Cardiac assessment: caution in patients with heart failure.
  • Renal impairment: adjust dose if significant renal dysfunction exists.
  • Store at ambient temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Itraconazole has several clinically important drug interactions.

Major Interactions (Avoid)

  • Rifampin, carbamazepine, phenytoin, or St. John's wort (strong CYP3A4 inducers).
  • Simvastatin or lovastatin (risk of severe myopathy).
  • Certain protease inhibitors (e.g., ritonavir) that markedly increase itraconazole levels.

Moderate Interactions (Monitor Closely)

  • Warfarin (enhanced anticoagulant effect).
  • Oral contraceptives (reduced efficacy).
  • Calcium channel blockers (e.g., verapamil) may increase plasma concentrations.
  • Macrolide antibiotics (e.g., erythromycin) may raise itraconazole levels.
  • HIV protease inhibitors (e.g., saquinavir) requiring dose adjustment.

Frequently Asked Questions

Itraconazol Al contains itraconazole, an azole antifungal indicated for dermatophyte infections, onychomycosis, systemic candidiasis, aspergillosis, and blastomycosis. It is prescribed by a qualified healthcare professional based on the specific fungal infection and patient condition.

Itraconazole blocks the fungal enzyme lanosterol 14α‑demethylase, preventing the synthesis of ergosterol, an essential component of fungal cell membranes. This disruption compromises membrane integrity, inhibiting fungal growth and leading to the resolution of the infection.

The dosage of Itraconazol Al is individualized by the prescribing clinician according to the infection type, severity, patient weight, age, and renal or hepatic function. Patients should follow the exact regimen provided by their healthcare provider.

Itraconazol Al is classified as Pregnancy Category D, indicating evidence of risk to the fetus. It should not be used during pregnancy unless the potential benefit justifies the risk. Breastfeeding is not recommended while taking itraconazole because it may pass into milk.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Itraconazol Al. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and necessary import documentation.

Itraconazol Al offers a broad spectrum of activity against yeasts and molds, often preferred for chronic pulmonary aspergillosis and onychomycosis. Compared with fluconazole, itraconazole has a wider mold coverage but may have more drug‑interaction potential due to CYP3A4 inhibition.

Store Itraconazol Al at ambient temperature, below 25 °C, in its original container. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations to maintain its stability and potency.

Itraconazol Al is taken orally, usually with a full glass of water. The tablet or capsule should be swallowed whole and not crushed or chewed unless directed otherwise by a healthcare professional.

Serious risks include hepatotoxicity, severe skin reactions such as Stevens‑Johnson syndrome, congestive heart failure, and QT interval prolongation. Patients should be monitored for signs of liver dysfunction, cardiac symptoms, and skin changes throughout therapy.

Itraconazol Al should be avoided in patients with known hypersensitivity to itraconazole or any azole antifungal, those with uncontrolled heart failure, severe hepatic impairment, or in pregnant women unless the benefit outweighs the risk. Consultation with a healthcare provider is essential before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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