Product image of Itraconazol Cf (Itraconazole) supplied by GNH India

Itraconazol Cf

Active Ingredient:
Itraconazole
Origin:
EU

Itraconazol Cf (Itraconazole)

Itraconazole, the active ingredient in Itraconazol Cf, is an azole antifungal presented as an oral formulation for oral use. It treats systemic mycoses, dermatophytosis, onychomycosis and candidiasis in adult patients.
GNH India supplies Itraconazol Cf as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Centrafarm B.V.

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Indications & Clinical Uses

Itraconazole is used to treat fungal infections that affect various organ systems and skin structures.

  • Systemic mycoses: effective against histoplasmosis, blastomycosis and coccidioidomycosis, reducing fungal burden and preventing disease progression.
  • Dermatophytosis and onychomycosis: clears skin and nail infections caused by dermatophytes, improving appearance and symptoms.
  • Candidiasis: treats oral, esophageal and systemic Candida infections, relieving discomfort and preventing dissemination.

How It Works

  • Itraconazole inhibits the fungal lanosterol 14α‑demethylase, a cytochrome P450 enzyme essential for converting lanosterol to ergosterol. By blocking ergosterol synthesis, the drug disrupts the fungal cell membrane, leading to increased permeability and inhibition of fungal growth.

Side Effects

Itraconazole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: transient cranial discomfort.
  • Abdominal pain: cramping or discomfort in the abdomen.
  • Diarrhea: loose stools occurring during therapy.
  • Rash: mild skin redness or itching.
  • Elevated liver enzymes: mild, reversible changes in liver function tests.

Serious or Rare Side Effects

  • Hepatotoxicity: significant liver injury requiring monitoring.
  • Congestive heart failure: worsening of pre‑existing cardiac conditions.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Visual disturbances: blurred vision or photopsia.
  • Peripheral edema: swelling of extremities.
  • Anaphylaxis: rare but life‑threatening allergic reaction.

Precautions & Warnings

Before initiating itraconazole therapy, consider the following safety measures.

  • Liver function: assess baseline hepatic enzymes and monitor periodically.
  • Cardiac status: avoid in patients with existing heart failure.
  • Drug interactions: review concomitant medications for potential CYP3A4 interactions.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Renal impairment: adjust dosing only under medical supervision.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Itraconazole interacts with several drug classes; careful management is required.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): markedly reduce itraconazole exposure.
  • Certain antiarrhythmics (e.g., quinidine, amiodarone): increase risk of cardiac toxicity.
  • HIV protease inhibitors (e.g., ritonavir): may cause dangerous plasma level elevations.

Moderate Interactions (Monitor Closely)

  • Statins (e.g., simvastatin, lovastatin): increased risk of myopathy.
  • Benzodiazepines (e.g., midazolam, triazolam): enhanced sedative effects.
  • Calcium channel blockers (e.g., verapamil): possible increased plasma concentrations.
  • Oral contraceptives: reduced efficacy, consider alternative contraception.

Frequently Asked Questions

Itraconazol Cf contains itraconazole, an azole antifungal indicated for systemic mycoses such as histoplasmosis, blastomycosis and coccidioidomycosis, for skin and nail infections like dermatophytosis and onychomycosis, and for various forms of candidiasis including oral, esophageal and systemic infections.

Itraconazole blocks the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. Without ergosterol, the fungal cell membrane becomes unstable, leading to impaired growth and eventual death of the fungus.

The specific dose of Itraconazol Cf is determined by the prescribing clinician based on the infection type, severity, patient weight, renal and hepatic function, and other individual factors. Patients should follow the exact regimen provided by their healthcare professional.

Safety data for itraconazole in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Itraconazole belongs to the azole class, offering broad‑spectrum activity against many yeasts and molds. Compared with polyenes like amphotericin B, itraconazole is orally administered and generally better tolerated, though it has more drug‑interaction potential due to CYP3A4 inhibition.

Store Itraconazol Cf at temperatures below 25 °C, in its original container, protected from moisture and direct sunlight. Do not expose the product to excessive heat or humidity to maintain its stability.

Itraconazol Cf is taken orally, usually with a full glass of water. The tablet or capsule should be swallowed whole and not crushed, unless the prescribing information specifically advises otherwise.

Serious risks include hepatotoxicity, congestive heart failure exacerbation, severe skin reactions such as Stevens‑Johnson syndrome, and visual disturbances. Patients should be monitored for signs of liver dysfunction, cardiac symptoms, and any unusual skin or eye changes.

Itraconazol Cf is contraindicated in patients with known hypersensitivity to itraconazole or any azole antifungal, and it should be avoided in individuals with uncontrolled heart failure. Caution is also advised for patients with severe liver disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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