Itraconazol Dura (Itraconazole)

Itraconazole blocks the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By preventing ergosterol formation, the drug disrupts the fungal cell membrane, increasing its permeability and inhibiting fungal growth and replication.

The specific dose and duration are determined by the prescribing clinician based on the type and severity of the infection, patient weight, renal and hepatic function, and other individual factors. No standard dose is provided here.

Safety data for itraconazole during pregnancy and lactation are limited. The drug should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and it is generally avoided unless absolutely necessary.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

The most common alternative in the azole class is fluconazole, which has a broader spectrum against Candida but less activity against Aspergillus and dermatophytes. Itraconazole offers stronger activity against molds such as Aspergillus and is often preferred for onychomycosis, whereas fluconazole is typically used for uncomplicated Candida infections.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original packaging to protect from moisture and light. Do not store in a humid environment such as a bathroom cabinet, and keep out of reach of children.

Itraconazol Dura is administered orally. It may be taken with food to improve absorption, especially the capsule form. The tablet or capsule should be swallowed whole with a full glass of water and not chewed or crushed unless specifically instructed by a healthcare professional.

The most serious adverse reactions include hepatotoxicity leading to severe liver injury, congestive heart failure due to negative inotropic effects, and severe allergic reactions such as anaphylaxis. Patients should be monitored for signs of liver dysfunction, shortness of breath, swelling, or rash and seek immediate medical attention if they occur.

Itraconazol Dura should be avoided in individuals with known hypersensitivity to itraconazole or any azole antifungal, in patients with severe hepatic impairment, and in those with established congestive heart failure. Caution is also advised for patients taking medications that strongly interact with itraconazole.